Published Online
on February 16, 2004

A more recent version of this article appeared on February 24, 2004

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Submitted on September 17, 2003
Revised on November 13, 2003
Accepted on November 18, 2003

Incidence, Mechanism, Predictors, and Long-Term Prognosis of Late Stent Malapposition After Bare-Metal Stent Implantation

Myeong-Ki Hong MD, PhD, Gary S. Mintz MD, Cheol Whan Lee MD, PhD, Young-Hak Kim MD, Seung-Whan Lee MD, Jong-Min Song MD, PhD, Ki-Hoon Han MD, Duk-Hyun Kang MD, PhD, Jae-Kwan Song MD, PhD, Jae-Joong Kim MD, PhD, Seong-Wook Park MD, PhD, and Seung-Jung Park MD, PhD^*

From the Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; and the Cardiovascular Research Foundation, New York, NY (G.S.M.).

^* To whom correspondence should be addressed. E-mail: sjpark{at}amc.seoul.kr.

Background--Predictors and long-term prognosis of late stent malapposition (LSM) after bare-metal stent (BMS) implantation are unknown.

Methods and Results--We evaluated the incidence, mechanisms, predictors, and long-term prognosis of LSM after BMS implantation in 881 patients (992 native lesions) in whom intravascular ultrasound was performed at index and 6-month follow-up. LSM was defined as a separation of stent struts from the intimal surface of the arterial wall that was not presented at stent implantation. LSM occurred in 54 patients with 54 lesions (5.4% overall); the incidence was 10.3% (9 of 87) after directional coronary atherectomy (DCA) before stenting and 11.5% (11 of 96) after primary stenting in acute myocardial infarction (P=0.031 and P=0.007, respectively, versus elective stenting with conventional balloon pre-dilation, 4.3% [30 of 692]). There was an increase of external elastic membrane area (18.9±3.9 to 24.5±5.1 mm², P<0.001) that was greater than the increase in plaque area (9.6±3.0 to 11.4±2.9 mm², P<0.001). Independent predictors of LSM were primary stenting in acute myocardial infarction (P=0.023, OR=2.55, 95% CI=1.14 to 5.69) and DCA before stenting (P=0.025, OR=3.02, 95% CI=1.15 to 7.96). There were no significant differences in major adverse cardiac events between LSM and non-LSM groups during mean 3-year follow-up (1.9% versus 1.8%, respectively, P=NS).

Conclusions--LSM occurs in 5% after BMS implantation. The predictors of LSM are primary stenting in acute myocardial infarction and DCA before stenting. Compared with complete stent apposition at follow-up, LSM after BMS implantation is not associated with any major adverse cardiac events during a mean 3-year follow-up after detection of LSM.

Key words: ultrasonics • stents • restenosis

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