on November 24, 2003
Published online before print November 24, 2003, doi: 10.1161/01.CIR.0000103666.25660.77
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 10, 2003
From Erasmus MC, Thoraxcenter, Rotterdam, the Netherlands; Institute Dante Pazzanese Cardiology (J.E.S.), Sao Paulo, Brazil; Centro Cuore Columbus (A.C.), Milan, Italy; and Institut Cardiovasculaire Paris Sud (M.-C.M.), Massy, France. * To whom correspondence should be addressed. E-mail: p.w.j.c.serruys{at}erasmusmc.nl.
Background--Incomplete stent apposition (ISA) has been previously documented after sirolimus-eluting stent (SES) implantation. The aim of this study was to investigate the long-term intravascular ultrasound (IVUS) findings of ISA in patients who received SES. Methods and Results--A total of 13 patients who received SES and showed ISA at follow-up IVUS (follow-up I) were investigated. IVUS was performed on all of these patients 12 months later (follow-up II). Quantitative ISA area measurement was also performed at follow-up I and II. No vascular remodeling was observed in the vessel segment with ISA; external elastic membrane area was 19.4±6.6 versus 19.5±6.4 mm2 at follow-up I and II, respectively. There was also no significant change in external elastic membrane area between vessel segment with ISA and without ISA (+1.5% versus -3.0%, respectively; P=0.27) at late follow-up. The ISA area, either including (2.5±1.7 versus 3.8±6.3 mm2; P=NS) or excluding (2.5±1.8 versus 2.4±1.7 mm2; P=NS) a single patient with aneurysm formation, was not significantly different between follow-up I and II. One patient manifested a coronary aneurysm in the stented segment at late follow-up that was probably present at the initial follow-up but masked by thrombus. It was successfully treated with a covered stent. All patients were asymptomatic, and no patient experienced late thrombotic occlusion. Conclusions--Vessel dimensions and area of ISA did not change over time, except for 1 coronary aneurysm that became apparent. ISA after implantation of a SES was not associated with adverse events at late follow-up.
Revised on September 21, 2003
Accepted on October 9, 2003
Long-Term Follow-Up of Incomplete Stent Apposition in Patients Who Received Sirolimus-Eluting Stent for De Novo Coronary Lesions. An Intravascular Ultrasound Analysis
Muzaffer Degertekin MD,
Key words: stents • vessels • coronary disease
This article has been cited by other articles:
 |
|
 |
|
  K. Waseda, A. Miyazawa, J. Ako, T. Hasegawa, I. Tsujino, R. Sakurai, P. G. Yock, Y. Honda, D. E. Kandzari, M. B. Leon, et al. Intravascular Ultrasound Results From the ENDEAVOR IV Trial: Randomized Comparison Between Zotarolimus- and Paclitaxel-Eluting Stents in Patients With Coronary Artery Disease J. Am. Coll. Cardiol. Intv., August 1, 2009; 2(8): 779 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gonzalo, P. Barlis, P. W. Serruys, H. M. Garcia-Garcia, Y. Onuma, J. Ligthart, and E. Regar Incomplete Stent Apposition and Delayed Tissue Coverage Are More Frequent in Drug-Eluting Stents Implanted During Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Than in Drug-Eluting Stents Implanted for Stable/Unstable Angina: Insights From Optical Coherence Tomography J. Am. Coll. Cardiol. Intv., May 1, 2009; 2(5): 445 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Colombo and A. Latib Late incomplete stent apposition after drug-eluting stent implantation: a true risk factor or "an innocent bystander"? Heart, March 1, 2008; 94(3): 253 - 254. [Full Text] [PDF]
|
|
|
|
|
|
R Hoffmann, M-C Morice, J W Moses, P J Fitzgerald, L Mauri, G Breithardt, J Schofer, P W Serruys, H-P Stoll, and M B Leon Impact of late incomplete stent apposition after sirolimus-eluting stent implantation on 4-year clinical events: intravascular ultrasound analysis from the multicentre, randomised, RAVEL, E-SIRIUS and SIRIUS trials Heart, March 1, 2008; 94(3): 322 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aoki, A. Kirtane, M. B. Leon, and G. Dangas Coronary artery aneurysms after drug-eluting stent implantation. J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 14 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Alfonso, A. Suarez, M. J. Perez-Vizcayno, R. Moreno, J. Escaned, C. Banuelos, P. Jimenez, E. Bernardo, D. J. Angiolillo, R. Hernandez, et al. Intravascular Ultrasound Findings During Episodes of Drug-Eluting Stent Thrombosis J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2095 - 2097. [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Hong, G. S. Mintz, C. W. Lee, D.-W. Park, S.-W. Lee, Y.-H. Kim, D.-H. Kang, S.-S. Cheong, J.-K. Song, J.-J. Kim, et al. Impact of Late Drug-Eluting Stent Malapposition on 3-Year Clinical Events J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1515 - 1516. [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holmes Jr, D. J. Kereiakes, W. K. Laskey, A. Colombo, S. G. Ellis, T. D. Henry, J. J. Popma, P. W.J.C. Serruys, T. Kimura, D. O. Williams, et al. Thrombosis and Drug-Eluting Stents: An Objective Appraisal J. Am. Coll. Cardiol., July 10, 2007; 50(2): 109 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Siqueira, A. A. Abizaid, J. d. R. Costa, F. Feres, L. A. Mattos, R. Staico, A. A. Abizaid, L. F. Tanajura, A. Chaves, M. Centemero, et al. Late incomplete apposition after drug-eluting stent implantation: incidence and potential for adverse clinical outcomes Eur. Heart J., June 1, 2007; 28(11): 1304 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Holmes Jr Coming close and then pulling away Eur. Heart J., June 1, 2007; 28(11): 1275 - 1276. [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Mintz What to Do About Late Incomplete Stent Apposition? Circulation, May 8, 2007; 115(18): 2379 - 2381. [Full Text] [PDF]
|
|
|
|
|
|
E. Camenzind, P. G. Steg, and W. Wijns A Cause for Concern Circulation, March 20, 2007; 115(11): 1440 - 1455. [Full Text] [PDF]
|
|
|
|
|
|
J. Fajadet, W. Wijns, G.-J. Laarman, K.-H. Kuck, J. Ormiston, T. Munzel, J. J. Popma, P. J. Fitzgerald, R. Bonan, R. E. Kuntz, et al. Randomized, Double-Blind, Multicenter Study of the Endeavor Zotarolimus-Eluting Phosphorylcholine-Encapsulated Stent for Treatment of Native Coronary Artery Lesions: Clinical and Angiographic Results of the ENDEAVOR II Trial Circulation, August 22, 2006; 114(8): 798 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Mintz and N. J. Weissman Intravascular Ultrasound in the Drug-Eluting Stent Era J. Am. Coll. Cardiol., August 1, 2006; 48(3): 421 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jimenez-Quevedo, M. Sabate, D. J. Angiolillo, M. A. Costa, F. Alfonso, J. A. Gomez-Hospital, R. Hernandez-Antolin, C. Banuelos, J. Goicolea, F. Fernandez-Aviles, et al. Vascular Effects of Sirolimus-Eluting Versus Bare-Metal Stents in Diabetic Patients: Three-Dimensional Ultrasound Results of the Diabetes and Sirolimus-Eluting Stent (DIABETES) Trial J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2172 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Lee, H.-C. Tan, and Y.-T. Lim Update on Drug-Eluting Stents for Prevention of Restenosis Asian Cardiovasc Thorac Ann, February 1, 2006; 14(1): 75 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Hong, G. S. Mintz, C. W. Lee, D.-W. Park, K.-M. Park, B.-K. Lee, Y.-H. Kim, J.-M. Song, K.-H. Han, D.-H. Kang, et al. Late Stent Malapposition After Drug-Eluting Stent Implantation: An Intravascular Ultrasound Analysis With Long-Term Follow-Up Circulation, January 24, 2006; 113(3): 414 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kelbaek, L. Thuesen, S. Helqvist, L. Klovgaard, E. Jorgensen, S. Aljabbari, K. Saunamaki, L. R. Krusell, G. V.H. Jensen, H. E. Botker, et al. The Stenting Coronary Arteries in Non-stress/benestent Disease (SCANDSTENT) Trial J. Am. Coll. Cardiol., January 17, 2006; 47(2): 449 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aoki, A. Colombo, D. Dudek, A. P. Banning, J. Drzewiecki, K. Zmudka, F. Schiele, M. E. Russell, J. Koglin, P. W. Serruys, et al. Peristent Remodeling and Neointimal Suppression 2 Years After Polymer-Based, Paclitaxel-Eluting Stent Implantation: Insights From Serial Intravascular Ultrasound Analysis in the TAXUS II Study Circulation, December 20, 2005; 112(25): 3876 - 3883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kelbaek, L. Thuesen, S. Helqvist, L. Klovgaard, E. Jorgensen, S. Aljabbari, K. Saunamaki, L. R. Krusell, G. V.H. Jensen, H. E. Botker, et al. The Stenting Coronary Arteries in Non-stress/benestent Disease (SCANDSTENT) Trial J. Am. Coll. Cardiol., December 13, 2005; (2005) j.jacc.2005.10.045v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Balakrishnan, A. R. Tzafriri, P. Seifert, A. Groothuis, C. Rogers, and E. R. Edelman Strut Position, Blood Flow, and Drug Deposition: Implications for Single and Overlapping Drug-Eluting Stents Circulation, June 7, 2005; 111(22): 2958 - 2965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanabe, P. W. Serruys, M. Degertekin, E. Grube, G. Guagliumi, W. Urbaszek, J. Bonnier, J.-M. Lablanche, T. Siminiak, J. Nordrehaug, et al. Incomplete Stent Apposition After Implantation of Paclitaxel-Eluting Stents or Bare Metal Stents: Insights From the Randomized TAXUS II Trial Circulation, February 22, 2005; 111(7): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Werner, A. Krack, G. Schwarz, D. Prochnau, S. Betge, and H. R. Figulla Prevention of lesion recurrence in chronic total coronary occlusions by paclitaxel-eluting stents J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2301 - 2306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Virmani, G. Guagliumi, A. Farb, G. Musumeci, N. Grieco, T. Motta, L. Mihalcsik, M. Tespili, O. Valsecchi, and F. D. Kolodgie Localized Hypersensitivity and Late Coronary Thrombosis Secondary to a Sirolimus-Eluting Stent: Should We Be Cautious? Circulation, February 17, 2004; 109(6): 701 - 705. [Abstract] [Full Text] [PDF]
|
|