on October 20, 2003
Circulation. 2003
Published online before print October 20, 2003, doi: 10.1161/01.CIR.0000097109.90783.FC
Published online before print October 20, 2003, doi: 10.1161/01.CIR.0000097109.90783.FC
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Submitted on April 7, 2003
From the Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC (M.C., B.W.J.H.P., B.J.N., M.P.); University of Pittsburgh, Pittsburgh, Pa (A.B.N., K.S.-T.); University of Tennessee, Memphis (S.B.K.); University of California, San Francisco (S.M.R.); Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Md (J.D., T.B.H.); and Intramural Research Program, National Institute on Aging, Baltimore, Md (E.M.S.). * To whom correspondence should be addressed. E-mail: mcesari{at}wfubmc.edu.
Background--Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. Methods and Results--The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor- Conclusions--Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.
Revised on August 12, 2003
Accepted on August 14, 2003
Inflammatory Markers and Onset of Cardiovascular Events. Results From the Health ABC Study
Matteo Cesari MD*,
(TNF-) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95% CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95% CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95% CI, 1.40 to 2.12). TNF- showed significant associations with CHD (per TNF- SD increase: RR, 1.22; 95% CI, 1.04 to 1.43) and CHF (per TNF- SD increase: RR, 1.59; 95% CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95% CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile.
Key words: cytokines • cardiovascular disease • inflammation
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E. M. Stuveling, S. J. L. Bakker, H. L. Hillege, P. E. de Jong, R. O. B. Gans, and D. de Zeeuw Biochemical risk markers: a novel area for better prediction of renal risk? Nephrol. Dial. Transplant., March 1, 2005; 20(3): 497 - 508. [Full Text] [PDF]
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M. Valgimigli, C. Ceconi, P. Malagutti, E. Merli, O. Soukhomovskaia, G. Francolini, G. Cicchitelli, A. Olivares, G. Parrinello, G. Percoco, et al. Tumor Necrosis Factor-{alpha} Receptor 1 Is a Major Predictor of Mortality and New-Onset Heart Failure in Patients With Acute Myocardial Infarction: The Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) Study Circulation, February 22, 2005; 111(7): 863 - 870. [Abstract] [Full Text] [PDF]
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M. Weger, I. Steinbrugger, A. Haas, W. Marz, Y. El-Shabrawi, W. Weger, O. Schmut, and W. Renner Role of the Interleukin-6 -174 G>C Gene Polymorphism in Retinal Artery Occlusion Stroke, February 1, 2005; 36(2): 249 - 252. [Abstract] [Full Text] [PDF]
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L. Ibanez and F. de Zegher Ethinylestradiol-Drospirenone, Flutamide-Metformin, or Both for Adolescents and Women with Hyperinsulinemic Hyperandrogenism: Opposite Effects on Adipocytokines and Body Adiposity J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1592 - 1597. [Abstract] [Full Text] [PDF]
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