Published Online
on September 2, 2003

A more recent version of this article appeared on September 9, 2003

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Submitted on June 1, 2003
Revised on July 22, 2003
Accepted on July 22, 2003

Reverse Remodeling of Sinus Node Function After Catheter Ablation of Atrial Fibrillation in Patients With Prolonged Sinus Pauses

Mélèze Hocini MD^*, Prashanthan Sanders MBBS, Isabel Deisenhofer MD, Pierre Jaïs MD, Li-Fern Hsu MBBS, Christophe Scavée MD, Rukshen Weerasoriya BMedSc(Hons), MBBS, Florence Raybaud MD, Laurent Macle MD, Dipen C. Shah MD, Stéphane Garrigue MD, Philippe Le Metayer MD, Jacques Clémenty MD, and Michel Haïssaguerre MD

From Hôpital Cardiologique du Haut-Lévêque, Bordeaux, France.

^* To whom correspondence should be addressed. E-mail: jacques.clementy{at}pu.u-bordeaux2.fr.

Background--Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF.

Methods and Results--Twenty patients with paroxysmal AF and prolonged sinus pauses (3 seconds) on termination of AF underwent ablation between May 1995 and November 2002. Patients with sinus pauses independent of episodes of AF were excluded from the analysis. The procedure included pulmonary vein and linear atrial ablation. After ablation, sinus node function was assessed during the first week and at 1, 3, and 6 months, by 24-hour ambulatory monitoring to determine the mean heart rate and heart rate range, and by exercise testing to determine the maximal heart rate. Corrected sinus node recovery time was determined at the completion of ablation and at 24.0±11.3 months at 600 and 400 ms. After AF ablation, there was a significant improvement of sinus node function, with an increase in the mean heart rate (P=0.001), maximal heart rate (P<0.0001), and heart rate range (P<0.0001). The corrected sinus node recovery time decreased in all patients evaluated at 600 ms (P=0.016) and 400 ms (P=0.019). At 26.0±17.6 months, 18 patients (85%) had no recurrence of AF (in the absence of medication), with no symptoms attributable to bradycardia or sinus pauses on ambulatory monitoring. Two patients had infrequent episodes of AF, 1 requiring pacemaker implantation.

Conclusion--Prolonged sinus pauses after paroxysms of AF may result from depression of sinus node function that can be eliminated by curative ablation of AF. This is accompanied by improvement in parameters of sinus node function, suggesting reverse remodeling of the sinus node.

Key words: ablation • atrium • arrhythmia • fibrillation • sinoatrial node

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