Published Online
on August 18, 2003

A more recent version of this article appeared on September 2, 2003

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Submitted on November 8, 2002
Revised on June 12, 2003
Accepted on June 12, 2003

Safety of an Aspirin-Alone Regimen After Intracoronary Stenting With a Heparin-Coated Stent. Final Results of the HOPE (HEPACOAT and an Antithrombotic Regimen of Aspirin Alone) Study

Roxana Mehran MD^*, Eve D. Aymong MD, MS, Dale T. Ashby MD, Tim Fischell MD, Hall Whitworth Jr MD, Robert Siegel MD, William Thomas MD, S. Chiu Wong MD, Raj Narasimaiah MD, Alexandra J. Lansky MD, and Martin B. Leon MD

From the Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY (R.M., D.A., E.A., R.N., A.L., M.L.); Borgess Medical Center, Kalamazoo, Mich (T.F.); Florida Heart Institute, Orlando (H.W.); Advanced Cardiovascular Specialists, Gilbert, Ariz (R.S.); Medical College of Ohio, Toledo (W.T.); and New York Presbyterian Hospital, New York, NY (S.C.W.).

^* To whom correspondence should be addressed. E-mail: rmehran{at}crf.org.

Background--Stent thrombosis is an infrequent complication of intracoronary stenting that often has devastating clinical consequences. This study assesses the additional benefit of heparin coating with the BX VELOCITY Balloon-Expandable Stent with HEPACOAT Carmeda end-point attached heparin (HEPACOAT) in patients with de novo or restenotic native coronary artery lesions treated with aspirin monotherapy after optimal stenting.

Methods and Results--This was a multicenter, prospective, nonrandomized, pilot study. Two hundred patients (69% men; mean age, 64.1±11.2 years) meeting the eligibility criteria were treated with the HEPACOAT stent and aspirin alone after stenting. Any other antiplatelet or anticoagulation therapy was not permitted. Procedural success was achieved in all patients. There were 3 postprocedural non-Q-wave myocardial infarctions. The primary end point of stent thrombosis at 30 days occurred in 2 of 200 patients (1%): in one after blunt chest trauma and in the other in the setting of essential thrombocytosis. Major adverse cardiac events (death, myocardial infarction, target lesion revascularization, and coronary artery bypass grafting) were observed at 30 days in 5 of 200 (2.5%) patients.

Conclusions--The BX VELOCITY stent with HEPACOAT and aspirin alone after the procedure was safe in select patients with de novo or restenotic lesions in native coronary arteries. Heparin coating provides additional protection against stent thrombosis.

Key words: stents • heparin • thrombosis • angioplasty

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