Published Online
on July 14, 2003

A more recent version of this article appeared on August 5, 2003

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Submitted on February 4, 2003
Revised on April 17, 2003
Accepted on May 9, 2003

Platelet P-Selectin Expression Is Associated With Atherosclerotic Wall Thickness in Carotid Artery in Humans

Hidenori Koyama MD, PhD^*, Takaaki Maeno MD, Shinya Fukumoto MD, PhD, Takuhito Shoji MD, Takahisa Yamane MD, PhD, Hisayo Yokoyama MD, Masanori Emoto MD, PhD, Tetsuo Shoji MD, PhD, Hideki Tahara MD, PhD, Masaaki Inaba MD, PhD, Masayuki Hino MD, Atsushi Shioi MD, PhD, Takami Miki MD, PhD, and Yoshiki Nishizawa MD, PhD

From the Departments of Metabolism, Endocrinology and Molecular Medicine (H.K., T. Maeno, S.F., Takuhito Shoji, H.Y., M.E., Tetsuo Shoji, H.T., M.I., Y.N.), Hematology (T.Y., M.H.), Cardiovascular Medicine (A.S.), and Geriatrics and Neurology (T. Miki), Osaka City University Graduate School of Medicine, Osaka, Japan.

^* To whom correspondence should be addressed. E-mail: hidekoyama{at}med.osaka-cu.ac.jp.

Background--Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.

Methods and Results--Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index ) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index . Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.

Conclusions--Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.

Key words: atherosclerosis • cell adhesion molecules • diabetes mellitus • platelets

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