on August 18, 2003
Published online before print August 18, 2003, doi: 10.1161/01.CIR.0000080913.81393.B8
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Submitted on January 21, 2003
From the Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga. * To whom correspondence should be addressed. E-mail: EFord{at}cdc.gov.
Background--C-reactive protein is an emerging risk factor for cardiovascular disease. Although the relations between C-reactive protein and other risk factors for cardiovascular disease have been extensively studied in adults, the relations in children are not well understood. Methods and Results--Data from 2846 boys and girls 3 to 17 years of age who participated in the National Health and Nutrition Examination Survey, 1999 to 2000, a cross-sectional survey of the US population, were used. In univariate analyses, significant associations were observed between C-reactive protein concentration--measured with a high-sensitivity assay--and age, body mass index, systolic blood pressure, and triglyceride concentrations in both sexes. In multiple linear regression analyses, body mass index was the best predictor of C-reactive protein concentration. Age was positively associated with C-reactive protein concentration among boys 3 to 17 years of age. Some race or ethnic differences were present as well among boys 8 to 17 years of age and girls 8 to 11 years of age. Systolic blood pressure was positively associated with C-reactive protein among girls 12 to 17 years of age. Conclusions--Among the sociodemographic and cardiovascular disease risk factors, body mass index was the best predictor of C-reactive protein concentration in children.
Revised on April 23, 2003
Accepted on April 25, 2003
C-Reactive Protein Concentration and Cardiovascular Disease Risk Factors in Children. Findings From the National Health and Nutrition Examination Survey 1999-2000
Earl S. Ford MD, MPH*
Key words: cardiovascular diseases • pediatrics • proteins • risk factors
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