Published Online
on May 19, 2003

A more recent version of this article appeared on June 3, 2003

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Submitted on March 20, 2003
Accepted on April 9, 2003

Real-Time Magnetic Resonance Imaging-Guided Coronary Catheterization in Swine

Reed A. Omary MD, MS^*, Jordin D. Green MS, Brian E. Schirf MD, Yongzhong Li MD, J. Paul Finn MD, and Debiao Li PhD

From the Departments of Radiology (R.A.O., J.D.G., B.S., Y.L., J.P.F., D.L.) and Biomedical Engineering (J.D.G., D.L.), Northwestern University, Chicago, Ill.

^* To whom correspondence should be addressed. E-mail: romary{at}radiology.northwestern.edu.

Background--We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach.

Methods and Results--In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with dilute 4% gadolinium (Gd) contrast agent and coaxially inserted 0.030-inch diameter active guidewires as endovascular devices. For catheter tracking, we used a 2-dimensional (2D) inversion recovery-prepared spoiled gradient echo sequence at a temporal resolution of 7 frames/s. For guidewire tracking, we used 2D steady-state free precession imaging at a temporal resolution of 9 frames/s. Coronary artery catheterization under MRI guidance was successful in 12/12 pigs. Successful coronary catheterization was verified by obtaining MR angiographic images after direct catheter-based injections of dilute Gd.

Conclusions--Real-time MRI-guided catheterization of coronary arteries in swine is feasible via a percutaneous femoral artery approach. Selective coronary MR angiography can then be performed with dilute contrast agent injections.

Key words: magnetic resonance imaging • catheterization • arteries • angiography

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