Published Online
on May 5, 2003

A more recent version of this article appeared on May 13, 2003

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Submitted on November 18, 2002
Revised on February 25, 2003
Accepted on February 27, 2003

Treatment of Saphenous Vein Bypass Grafts With Ultrasound Thrombolysis. A Randomized Study (ATLAS)

Mandeep Singh MD, Uri Rosenschein MD, Kalon K.L. Ho MD, Peter B. Berger MD, Richard Kuntz MD, and David R. Holmes Jr MD^*

From the Division of Cardiovascular Diseases and Internal Medicine (M.S., P.B.B., D.R.H.), Mayo Clinic, Rochester, Minn; Tel Aviv Medical Center (U.R.), Tel Aviv, Israel; Beth Israel Deaconess Medical Center (K.K.L.H.), Boston, Mass; and Brigham and Women's Hospital (R.K.), Boston, Mass.

Background--Percutaneous coronary interventions (PCIs) in saphenous vein grafts (SVGs) with thrombus have a high frequency of distal embolization. Acolysis (therapeutic ultrasound) can break up thrombus in vitro in animal models and humans. Whether this is beneficial during percutaneous SVG interventions is unknown.

Methods and Results--We performed a trial of coronary ultrasound thrombolysis in which patients with an acute coronary syndrome undergoing PCI in SVGs were randomly assigned to receive acolysis or abciximab. The primary end point was a successful procedure, defined as final luminal diameter stenosis 30% or less with Thrombolysis In Myocardial Infarction grade 3 flow and freedom from major adverse cardiac events (composite of death, Q-wave, and non-Q-wave myocardial infarction [MI], emergency bypass procedure, disabling stroke, and target lesion revascularization). Of 181 enrolled, 92 received acolysis and 89 abciximab. Angiographic procedural success was achieved in 63% of acolysis patients and 82% of abciximab patients (P=0.008). Incidence of major adverse cardiac events at 30 days was 25% with acolysis and 12% with abciximab (P=0.036), attributable mainly to a greater frequency of non-Q-wave MI with acolysis (19.6% versus 7.9%, P=0.03). The incidence of Q-wave MI was also higher with acolysis (5.4% versus 2.2%, P=nonsignificant). The primary end point was achieved in 53.8% of acolysis patients and 73.1% of abciximab patients (P=0.014).

Conclusions--Use of therapeutic ultrasound in vein graft lesions in patients with acute coronary syndrome had poor angiographic outcome and increased the incidence of acute ischemic complications.

Key words: angioplasty • thrombolysis • ultrasonics

Related Article:

Percutaneous Treatment of Saphenous Vein Bypass Graft Obstructions: A Continuing Obstinate Problem

P.J. de Feyter
Circulation 2003 107: 2284-2286. [Extract] [Full Text]

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