on April 14, 2003
Circulation. 2003
Published online before print April 14, 2003, doi: 10.1161/01.CIR.0000066318.21784.43
Published online before print April 14, 2003, doi: 10.1161/01.CIR.0000066318.21784.43
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on December 31, 2002
From the Division of Cardiovascular Diseases (J.E.M., G.S.H., P.A.P., J.B.S., G.S.R., R.S.W., S.W.P., J.K.O.) and the Department of Biostatistics (K.R.B.), Mayo Clinic Rochester, Minn. * To whom correspondence should be addressed. E-mail: pellikka.patricia{at}mayo.edu.
Background--After acute myocardial infarction (AMI), diastolic function assessed by Doppler echocardiography provides important prognostic information that is incremental to systolic function. However, Doppler variables are affected by multiple factors and may change rapidly. In contrast, left atrial (LA) volume is less influenced by acute changes and reflects subacute or chronic diastolic function. This may be of importance when one assesses risk in patients with AMI. Methods and Results--Three hundred fourteen patients with AMI who had a transthoracic echocardiogram with assessment of left ventricular (LV) systolic and diastolic function and measurement of LA volume during admission were identified. The LA volume was corrected for body surface area, and the population was divided according to LA volume index of 32 mL/m2 (2 SDs above normal). LA volume index was >32 mL/m2 in 142 (45%). The primary study end point was all-cause mortality. During follow-up of 15 (range 0 to 33) months, 46 patients (15%) died. LA volume index was a powerful predictor of mortality and remained an independent predictor (hazard ratio 1.05 per 1-mL/m2 change, 95% CI 1.03 to 1.06, P<0.001) after adjustment for clinical factors, LV systolic function, and Doppler-derived parameters of diastolic function. Conclusions--Increased LA volume index is a powerful predictor of mortality after AMI and provides prognostic information incremental to clinical data and conventional measures of LV systolic and diastolic function.
Revised on February 20, 2003
Accepted on February 20, 2003
Left Atrial Volume. A Powerful Predictor of Survival After Acute Myocardial Infarction
Jacob E. Møller MD, PhD,
Key words: atrium • myocardial infarction • echocardiography • diastole
This article has been cited by other articles:
 |
|
 |
|
  S A Mollema, G Nucifora, and J J Bax Prognostic value of echocardiography after acute myocardial infarction Heart, November 1, 2009; 95(21): 1732 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rossi, P. L. Temporelli, M. Quintana, F. L. Dini, S. Ghio, G. S. Hillis, A. L. Klein, N. Ajmone Marsan, D. L. Prior, C. M. Yu, et al. Independent relationship of left atrial size and mortality in patients with heart failure: an individual patient meta-analysis of longitudinal data (MeRGE Heart Failure) Eur J Heart Fail, October 1, 2009; 11(10): 929 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Tripepi, F. Mattace-Raso, F. Mallamaci, F. A. Benedetto, J. Witteman, L. Malatino, and C. Zoccali Biomarkers of Left Atrial Volume: A Longitudinal Study in Patients With End Stage Renal Disease Hypertension, October 1, 2009; 54(4): 818 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Hofsten, B. B. Logstrup, J. E. Moller, P. A. Pellikka, and K. Egstrup Abnormal glucose metabolism in acute myocardial infarction influence on left ventricular function and prognosis. J. Am. Coll. Cardiol. Img., May 1, 2009; 2(5): 592 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Stevens, R. Farzaneh-Far, B. Na, M. A. Whooley, and N. B. Schiller Development of an echocardiographic risk-stratification index to predict heart failure in patients with stable coronary artery disease: the Heart and Soul study. J. Am. Coll. Cardiol. Img., January 1, 2009; 2(1): 11 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Quinones Role of echocardiography in predicting onset of heart failure in patients with stable coronary artery disease: is the whole greater than the sum of its parts? J. Am. Coll. Cardiol. Img., January 1, 2009; 2(1): 21 - 23. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meris, M. Amigoni, H. Uno, J. J. Thune, A. Verma, L. Kober, M. Bourgoun, J. J. McMurray, E. J. Velazquez, A. P. Maggioni, et al. Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo Study Eur. Heart J., January 1, 2009; 30(1): 56 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jarnert, A. Melcher, K. Caidahl, H. Persson, L. Ryden, and M. J. Eriksson Left atrial velocity vector imaging for the detection and quantification of left ventricular diastolic function in type 2 diabetes Eur J Heart Fail, November 1, 2008; 10(11): 1080 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fatema, K. R. Bailey, G. W. Petty, I. Meissner, M. Osranek, A. A. Alsaileek, B. K. Khandheria, T. S. Tsang, and J. B. Seward Increased Left Atrial Volume Index: Potent Biomarker for First-Ever Ischemic Stroke Mayo Clin. Proc., October 1, 2008; 83(10): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Ennezat, N. Lamblin, F. Mouquet, O. Tricot, P. Quandalle, V. Aumegeat, O. Equine, O. Nugue, B. Segrestin, P. de Groote, et al. The effect of ageing on cardiac remodelling and hospitalization for heart failure after an inaugural anterior myocardial infarction Eur. Heart J., August 2, 2008; 29(16): 1992 - 1999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rossi, M. Cicoira, S. Bonapace, G. Golia, L. Zanolla, L. Franceschini, and C. Vassanelli Left atrial volume provides independent and incremental information compared with exercise tolerance parameters in patients with heart failure and left ventricular systolic dysfunction Heart, November 1, 2007; 93(11): 1420 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bayes-Genis, R. Vazquez, T. Puig, C. Fernandez-Palomeque, J. Fabregat, A. Bardaji, D. Pascual-Figal, J. Ordonez-Llanos, M. Valdes, A. Gabarrus, et al. Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure Eur J Heart Fail, August 1, 2007; 9(8): 802 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sorajja, B. J. Gersh, D. A. Cox, M. G. McLaughlin, P. Zimetbaum, C. Costantini, T. Stuckey, J. E. Tcheng, R. Mehran, A. J. Lansky, et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction Eur. Heart J., July 2, 2007; 28(14): 1709 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Martos, J. Baugh, M. Ledwidge, C. O'Loughlin, C. Conlon, A. Patle, S. C. Donnelly, and K. McDonald Diastolic Heart Failure: Evidence of Increased Myocardial Collagen Turnover Linked to Diastolic Dysfunction Circulation, February 20, 2007; 115(7): 888 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pocar, A. Moneta, A. Grossi, and F. Donatelli Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow-Up Ann. Thorac. Surg., February 1, 2007; 83(2): 468 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gerdts, K. Wachtell, P. Omvik, J. E. Otterstad, L. Oikarinen, K. Boman, B. Dahlof, and R. B. Devereux Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment: Losartan Intervention for Endpoint Reduction in Hypertension Trial Hypertension, February 1, 2007; 49(2): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kamohara, Z. B. Popovic, M. Daimon, M. Martin, Y. Ootaki, M. Akiyama, F. Zahr, F. Cingoz, C. Ootaki, M. W. Kopcak Jr, et al. Impact of left atrial appendage exclusion on left atrial function J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 174 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.K. Oh Echocardiography in heart failure: Beyond diagnosis Eur J Echocardiogr, January 1, 2007; 8(1): 4 - 14. [Full Text] [PDF]
|
|
|
|
|
|
G A Whalley, G D Gamble, and R N Doughty Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies Heart, November 1, 2006; 92(11): 1588 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Moller, P. A. Pellikka, G. S. Hillis, and J. K. Oh Prognostic Importance of Diastolic Function and Filling Pressure in Patients With Acute Myocardial Infarction Circulation, August 1, 2006; 114(5): 438 - 444. [Full Text] [PDF]
|
|
|
|
 |
|
 W. P. Abhayaratna, J. B. Seward, C. P. Appleton, P. S. Douglas, J. K. Oh, A. J. Tajik, and T. S.M. Tsang Left Atrial Size: Physiologic Determinants and Clinical Applications J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2357 - 2363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Alsaileek, M. Osranek, K. Fatema, R. B. McCully, T. S. Tsang, and J. B. Seward Predictive Value of Normal Left Atrial Volume in Stress Echocardiography J. Am. Coll. Cardiol., March 7, 2006; 47(5): 1024 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S.M. Tsang, W. P. Abhayaratna, M. E. Barnes, Y. Miyasaka, B. J. Gersh, K. R. Bailey, S. S. Cha, and J. B. Seward Prediction of Cardiovascular Outcomes With Left Atrial Size: Is Volume Superior to Area or Diameter? J. Am. Coll. Cardiol., March 7, 2006; 47(5): 1018 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Lang, M. Bierig, R. B. Devereux, F. A. Flachskampf, E. Foster, P. A. Pellikka, M. H. Picard, M. J. Roman, J. Seward, J. Shanewise, et al. Recommendations for chamber quantification Eur J Echocardiogr, March 1, 2006; 7(2): 79 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M S Feinberg, V Boyko, J Leor, R Kuperstein, A Sagie, H Hod, S Matetzky, S Behar, and E Schwammenthal Differential value of left atrial systolic and diastolic volumes as independent predictors of congestive heart failure or early death in acute myocardial infarction. Heart, March 1, 2006; 92(3): 397 - 398. [Full Text] [PDF]
|
|
|
|
|
|
T. K. Lim, H. Ashrafian, G. Dwivedi, P. O. Collinson, and R. Senior Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure Eur J Heart Fail, January 1, 2006; 8(1): 38 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Osranek, F. Bursi, K. R. Bailey, B. R. Grossardt, R. D. Brown Jr, S. L. Kopecky, T. S. Tsang, and J. B. Seward Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up Eur. Heart J., December 1, 2005; 26(23): 2556 - 2561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bollmann First comes diagnosis then comes treatment: an underappreciated paradigm in atrial fibrillation management Eur. Heart J., December 1, 2005; 26(23): 2487 - 2489. [Full Text] [PDF]
|
|
|
|
|
|
F. H. Rutten, M.-J. M. Cramer, D. E. Grobbee, A. P.E. Sachs, J. H. Kirkels, J.-W. J. Lammers, and A. W. Hoes Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease Eur. Heart J., September 2, 2005; 26(18): 1887 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Weyman The year in echocardiography J. Am. Coll. Cardiol., February 1, 2005; 45(3): 448 - 455. [Full Text] [PDF]
|
|
|
|
|
|
K. J. Grande-Allen, A. G. Borowski, R. W. Troughton, P. L. Houghtaling, N. R. DiPaola, C. S. Moravec, I. Vesely, and B. P. Griffin Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: An extracellular matrix and echocardiographic study J. Am. Coll. Cardiol., January 4, 2005; 45(1): 54 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Pritchett, D. W. Mahoney, S. J. Jacobsen, R. J. Rodeheffer, B. L. Karon, and M. M. Redfield Diastolic dysfunction and left atrial volume: A population-based study J. Am. Coll. Cardiol., January 4, 2005; 45(1): 87 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Kernis, V. T. Nkomo, D. Messika-Zeitoun, B. J. Gersh, T. M. Sundt III, K. V. Ballman, C. G. Scott, H. V. Schaff, and M. Enriquez-Sarano Atrial Fibrillation After Surgical Correction of Mitral Regurgitation in Sinus Rhythm: Incidence, Outcome, and Determinants Circulation, October 19, 2004; 110(16): 2320 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Beinart, V. Boyko, E. Schwammenthal, R. Kuperstein, A. Sagie, H. Hod, S. Matetzky, S. Behar, M. Eldar, and M. S. Feinberg Long-term prognostic significance of left atrial volume in acute myocardial infarction J. Am. Coll. Cardiol., July 21, 2004; 44(2): 327 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Bunch, K. Chandrasekaran, B. J. Gersh, S. C. Hammill, D. O. Hodge, A. H. Khan, D. L. Packer, and P. A. Pellikka The prognostic significance of exercise-induced atrial arrhythmias J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1236 - 1240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Weyman The year in echocardiography J. Am. Coll. Cardiol., January 7, 2004; 43(1): 140 - 148. [Full Text] [PDF]
|
|