Published Online
on April 7, 2003

A more recent version of this article appeared on April 22, 2003

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Submitted on October 29, 2002
Revised on February 7, 2003
Accepted on February 7, 2003

₂-Adrenergic Receptor Polymorphisms and Risk of Incident Cardiovascular Events in the Elderly

Susan R. Heckbert MD, PhD^*, Lucia A. Hindorff MPH, Karen L. Edwards PhD, Bruce M. Psaty MD, PhD, Thomas Lumley PhD, David S. Siscovick MD, MPH, Zhonghua Tang PhD, J. Peter Durda BS ;, Richard A. Kronmal PhD, and Russell P. Tracy PhD

From the Departments of Epidemiology (S.R.H., L.A.H., K.L.E., B.M.P., D.S.S.), Medicine (B.M.P., D.S.S.), and Biostatistics (T.L., R.A.K.), University of Washington, Seattle, Wash, and Department of Pathology (Z.T., J.P.D., R.P.T.), University of Vermont, Burlington, Vt. Z. Tang is now at the Department of Medicine, Thomas Jefferson University, Philadelphia, Pa.

^* To whom correspondence should be addressed. E-mail: heckbert{at}u.washington.edu..

Background--Genetic polymorphisms at codons 16 and 27 of the ₂-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.

Methods and Results--A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the ₂-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of ₂-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.

Conclusions--The Glu27 allele of the ₂-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.

Key words: coronary disease • epidemiology • genetics • hypertension • stroke

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