on April 28, 2003
Published online before print April 28, 2003, doi: 10.1161/01.CIR.0000063577.32819.23
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Submitted on November 25, 2002
From the Experimental Interventional Laboratory, Department of Cardiovascular Medicine (Z.Z., K.W., M.S.P., F.F., X.Z., A.M.L., E.J.T.), Cleveland Clinic Foundation, Cleveland, Ohio; Mid American Heart Institute (S.P.M.), Saint Luke's Hospital, Kansas City, Mo; Borgess Hospital Research Institute (M.A.L.), Kalamazoo, Mich; and Columbia University (W.Q., Y.L., A.M.S., D.M.S.), College of Physician and Surgeons, New York, NY. * To whom correspondence should be addressed. E-mail: topole{at}ccf.org.
Background--Receptor for advanced-glycation end products (RAGE) and its ligands AGEs and S100/calgranulins have been implicated in a range of disorders. However, the role of RAGE/ligand interaction in neointimal hyperplasia after vascular injury remains unclear. Methods and Results--We examined the expression of RAGE and its ligands after balloon injury of the carotid artery in both Zucker diabetic and nondiabetic rats. Using a soluble portion of the extracellular domain of RAGE, we determined the effects of suppressing RAGE/ligand interaction on vascular smooth muscle cell (VSMC) proliferation and neointimal formation after arterial injury. We demonstrate a significantly increased accumulation of AGE and immunoreactivities of RAGE and S100/calgranulins in response to balloon injury in diabetic compared with nondiabetic rats. Blockade of RAGE/ligand interaction significantly decreased S100-stimulated VSMC proliferation in vitro and bromodeoxyuridine (BrdU)-labeled proliferating VSMC in vivo, and suppressed neointimal formation and increased luminal area in both Zucker diabetic and nondiabetic rats. Conclusions--These findings indicate that RAGE/ligand interaction plays a key role in neointimal formation after vascular injury irrespective of diabetes status and suggest a novel target to minimize neointimal hyperplasia.
Accepted on January 21, 2003
Receptor for AGE (RAGE) Mediates Neointimal Formation in Response to Arterial Injury
Zhongmin Zhou MD,
Key words: diabetes mellitus • angioplasty • restenosis • receptors
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