on April 14, 2003
Published online before print April 14, 2003, doi: 10.1161/01.CIR.0000062647.30366.98
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Submitted on October 17, 2002
From the Departments of Internal Medicine and Physiology and Biophysics, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City. * To whom correspondence should be addressed. E-mail: gerald-dibona{at}uiowa.edu.
Background--The renal vasoconstrictor response to renal nerve stimulation is greater in congestive heart failure (CHF) rats than in control rats. This study tested the hypothesis that the enhanced renal vasoconstrictor response to renal nerve stimulation in CHF is a result of an impairment in the low-pass filter function of the renal vasculature. Methods and Results--In response to conventional graded-frequency renal nerve stimulation, the reductions in renal blood flow at each stimulation frequency were greater in CHF rats than control rats. A pseudorandom binary sequence pattern of renal nerve stimulation was used to examine the frequency response of the renal vasculature. Although this did not affect the renal blood flow power spectrum in control rats, there was a 10-fold increase in renal blood flow power over the frequency range of 0.01 to 1.0 Hz in CHF rats. On analysis of transfer function gain, attenuation of the renal nerve stimulation input signal was similar in control and CHF rats over the frequency range of 0.001 to 0.1 Hz. However, over the frequency range of 0.1 to 1.0 Hz, although there was progressive attenuation of the input signal (-30 to -70 dB) in control rats, CHF rats exhibited a flat gain response (-20 dB) without progressive attenuation. Conclusions--The enhanced renal vasoconstrictor response to renal nerve stimulation in CHF rats is caused by an alteration in the low-pass filter function of the renal vasculature, resulting in a greater transfer of input signals into renal blood flow in the 0.1 to 1.0 Hz range.
Revised on January 16, 2003
Accepted on January 24, 2003
Frequency Response of the Renal Vasculature in Congestive Heart Failure
Gerald F. DiBona MD* and Linda L. Sawin
Key words: kidney • blood flow • vasculature • nervous system, sympathetic
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