on February 24, 2003
Published online before print February 24, 2003, doi: 10.1161/01.CIR.0000059938.95404.92
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Submitted on December 5, 2002
From the Departments of Surgery (T.V., T.L., P.J.E.H.M.K., G.W.H.S.), Clinical Chemistry (M.P.v.D.-V.), and Medical Microbiology (F.R.M.S., S.B.H., C.A.B.), University Hospital of Maastricht and Cardiovascular Research Institute of Maastricht, Maastricht, the Netherlands. * To whom correspondence should be addressed. E-mail: t.vainas{at}ah.unimaas.nl.
Background--Abdominal aortic aneurysms (AAA) are characterized by extensive transmural inflammation and C-reactive protein (CRP) has emerged as an independent risk factor for the development of cardiovascular disease. Therefore, we evaluated a possible association between serum CRP and aneurysm dimension in patients with asymptomatic AAA. Furthermore, the possibility of CRP production by aneurysmal tissue has been examined. Methods and Results--Serum CRP was determined highly sensitive (hsCRP) and aneurysmal size was measured in 39 patients with AAA. The presence of CRP mRNA was assessed in the aneurysmal tissue of 16 patients. Mean (SD) hsCRP was 3.23 (2.96) mg/L. After log-transformation, hsCRP correlated significantly with aneurysmal size (r=0.477, P=0.002). When the patients were divided into 3 equally sized groups according to hsCRP level, aortic diameter increased from lowest to upper hsCRP-tertile (49 mm, 61 mm, and 67 mm, respectively; P<0.05 for 3rd versus 1st tertile). This association persisted after correction for risk factors. CRP mRNA was found in 25% of aneurysmal aortic tissues. Conclusions--This is the first report showing that serum hsCRP is associated with aneurysmal size and that--in at least some patients--CRP may be produced by aneurysmal tissue. These data underscore the inflammatory nature of AAA formation, suggesting that serum hsCRP may serve as a marker of AAA disease and that CRP produced in vascular tissue might contribute to aneurysm formation.
Revised on January 14, 2003
Accepted on January 16, 2003
Serum C-Reactive Protein Level Is Associated With Abdominal Aortic Aneurysm Size and May Be Produced by Aneurysmal Tissue
Tryfon Vainas MD*,
Key words: aorta • aneurysm • inflammation
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