on March 24, 2003
Published online before print March 24, 2003, doi: 10.1161/01.CIR.0000057981.70380.45
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Submitted on November 6, 2002
From the Division of Electrophysiology (T.V.G., J.Z., G.R.), Hackensack University Medical Center, Hackensack, NJ; Duke Clinical Research Institute and Duke University School of Medicine (A.S.H., K.L.L.), Durham, NC; Brigham and Women's Hospital and Harvard Medical School (M.O.S.), Boston, Mass; University Hospital (R.Y.), London, Ontario, Canada; Lankenau Hospital (R.M.), Wynnewood, Pa; Baystate Medical Center (J.C.), Springfield, Mass; Alamance Regional Medical Center (A.P.), Burlington, NC; Maine Medical Center (J.L.), Portland, Maine; Mount Sinai Medical Center, Miami Heart Institute, and the University of Miami School of Medicine (G.A.L.), Miami Beach, Fla. * To whom correspondence should be addressed. E-mail: TayaVG{at}aol.com.
Background--Some current pacing systems can automatically detect and record atrial tachyarrhythmias that may be asymptomatic. We prospectively studied a 312-patient (pt) subgroup of MOST (MOde Selection Trial), a 2010-patient, 6-year randomized trial of DDDR versus VVIR pacing in sinus node dysfunction (SND). The purpose of the study was to correlate atrial high rate events (AHREs) detected by pacemaker diagnostics with clinical outcomes. Methods and Results--Pacemakers were programmed to log an AHRE when the atrial rate was >220 bpm for 10 consecutive beats. Analysis was confined to patients with at least 1 AHRE duration exceeding 5 minutes. The 312 patients were median age 74 years, 55% female, and 60% had a history of SVT. 160 of 312 (51.3%) patients enrolled had at least 1 AHRE >5 minutes duration over median follow-up of 27 months. Cox proportional hazards analysis assessed the relationship of AHREs with clinical events, adjusting for prognostic variables and baseline covariates. The presence of any AHRE was an independent predictor of the following: total mortality (hazard ratio AHRE versus no AHRE and 95% confidence intervals=2.48 [1.25, 4.91], P=0.0092); death or nonfatal stroke (2.79 [1.51, 5.15], P=0.0011); and atrial fibrillation (5.93 [2.88, 12.2], P=0.0001). There was no significant effect of pacing mode on the presence or absence of AHREs. Conclusions--AHRE detected by pacemakers in patients with SND identify patients that are more than twice as likely to die or have a stroke, and 6 times as likely to develop atrial fibrillation as similar patients without AHRE.
Revised on December 31, 2002
Accepted on January 7, 2003
Atrial High Rate Episodes Detected by Pacemaker Diagnostics Predict Death and Stroke. Report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST)
Taya V. Glotzer MD*,
Key words: fibrillation • pacemakers • arrhythmia detection • mortality • clinical trials
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