on February 17, 2003
Published online before print February 17, 2003, doi: 10.1161/01.CIR.0000054622.45012.12
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Submitted on October 15, 2002
From the Department of Public Health & Caring Sciences/Section of Geriatrics (K.B., B.Z., H.L.) and Department of Medical Sciences (L.L., B.A.), Uppsala University, Uppsala, Sweden. * To whom correspondence should be addressed. E-mail: Kristina.Bjorklund{at}pubcare.uu.se.
Background--Little is known about isolated ambulatory hypertension, a state with elevated ambulatory but normal office blood pressure (BP). This study aimed to investigate the prognostic significance of isolated ambulatory hypertension for cardiovascular morbidity in a population of elderly men. Methods and Results--At baseline, 24-hour ambulatory BP and metabolic and cardiac risk profiles were evaluated in 578 untreated 70-year-old men, participants of a population-based cohort. Subjects with isolated ambulatory hypertension (office BP <140/90 and daytime BP Conclusions--In the present study, isolated ambulatory hypertension as well as sustained hypertension predicted cardiovascular morbidity. The findings suggest that 24-hour ambulatory BP monitoring may disclose important prognostic information also in subjects characterized as normotensive according to office BP.
Revised on December 5, 2002
Accepted on December 5, 2002
Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men
Kristina Björklund MD*,
135/85) and sustained hypertension (office BP 140/90 and daytime BP 135/85) had increased plasma glucose, body mass index, and echocardiographically determined left ventricular relative wall thickness compared with normotensive subjects (office BP <140/90 and daytime BP <135/85). Seventy-two cardiovascular morbid events (2.37 per 100 person-years at risk) occurred over 8.4 years of follow-up. The prognostic value of isolated ambulatory and sustained hypertension was assessed with Cox proportional hazard regression. Multivariate models adjusting for serum cholesterol, smoking, and diabetes demonstrated that both isolated ambulatory hypertension (hazard ratio [HR], 2.77; 95% CI, 1.15 to 6.68) and sustained hypertension (HR, 2.94; 95% CI, 1.49 to 5.82) were independent predictors of cardiovascular morbidity. In a multivariate model with continuous BP variables, ambulatory daytime systolic BP (HR for 1 SD increase, 1.47; 95% CI, 1.09 to 1.97) was associated with an adverse outcome independently of office systolic BP.
Key words: blood pressure • hypertension • population • morbidity
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