on February 17, 2003
Published online before print February 17, 2003, doi: 10.1161/01.CIR.0000051465.94572.D0
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 6, 2002
From the Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group. * To whom correspondence should be addressed. E-mail: piermannuccio.mannucci{at}unimi.it.
Background--We investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state. Methods and Results--This nationwide case-control study involved 1210 patients who had survived a first myocardial infarction at an age of <45 years who underwent coronary arteriography in 125 coronary care units and 1210 healthy subjects matched for age, sex, and geographical origin. None of the 9 polymorphisms of genes encoding proteins involved in coagulation (G-455A Conclusions--This study provides no evidence supporting an association between 9 polymorphisms of genes encoding proteins involved in hemostasis and the occurrence of premature myocardial infarction or protection against it.
Revised on November 12, 2002
Accepted on November 13, 2002
No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age
Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group *
-fibrinogen: OR, 1.0; CI, 0.8 to 1.2; G1691A factor V: OR, 1.1; CI, 0.6 to 2.1; G20210A factor II: OR, 1.0; CI, 0.5 to 1.9; and G10976A factor VII: OR, 1.0; CI, 0.8 to 1.3), platelet function (C807T glycoprotein Ia: OR, 1.1; CI, 0.9 to 1.3; and C1565T glycoprotein IIIa: OR, 0.9; CI, 0.8 to 1.2), fibrinolysis (G185T factor XIII: OR, 1.2; CI, 0.9 to 1.6; and 4G/5G plasminogen activator inhibitor type 1: OR, 0.9; CI, 0.7 to 1.2), or homocysteine metabolism (C677T methylenetetrahydrofolate reductase: OR, 0.9; CI, 0.8 to 1.1) were associated with an increased or decreased risk of myocardial infarction.
Key words: genes • myocardial infarction • coagulation • platelets • fibrinolysis
This article has been cited by other articles:
 |
|
 |
|
  R. Bourouba, B. Houcher, F. Djabi, Y. Egin, and N. Akar The Prevalence of Methylenetetrahydrofolate Reductase 677 C-T, Factor V 1691 G-A, and Prothrombin 20210 G-A Mutations in Healthy Populations in Setif, Algeria Clinical and Applied Thrombosis/Hemostasis, October 1, 2009; 15(5): 529 - 534. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Marin, R. Gonzalez-Conejero, P. Capranzano, T. A. Bass, V. Roldan, and D. J. Angiolillo Pharmacogenetics in cardiovascular antithrombotic therapy. J. Am. Coll. Cardiol., September 15, 2009; 54(12): 1041 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Guella, V. Rimoldi, R. Asselta, D. Ardissino, M. Francolini, N. Martinelli, D. Girelli, F. Peyvandi, M. Tubaro, P. A. Merlini, et al. Association and Functional Analyses of MEF2A as a Susceptibility Gene for Premature Myocardial Infarction and Coronary Artery Disease Circ Cardiovasc Genet, April 1, 2009; 2(2): 165 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ferraresi, G. Campo, G. Marchetti, M. Pinotti, M. Valgimigli, D. Gemmati, R. Ferrari, and F. Bernardi Temporal and Genotype-Driven Variation of Factor VII Levels in Patients With Acute Myocardial Infarction Clinical and Applied Thrombosis/Hemostasis, February 1, 2009; 15(1): 119 - 122. [PDF]
|
|
|
|
 |
|
 P. Medina, S. Navarro, J. Corral, E. Zorio, V. Roldan, A. Estelles, A. Santamaria, F. Marin, J. Rueda, R. M. Bertina, et al. Endothelial protein C receptor polymorphisms and risk of myocardial infarction Haematologica, September 1, 2008; 93(9): 1358 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Koch, P. Hoppmann, J. Biele, J. C. Mueller, A. Schomig, and A. Kastrati Fibrinogen Genes and Myocardial Infarction: A Haplotype Analysis Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 758 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Zwicker, F. Peyvandi, R. Palla, R. Lombardi, M. T. Canciani, A. Cairo, D. Ardissino, L. Bernardinelli, K. A. Bauer, J. Lawler, et al. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size Blood, August 15, 2006; 108(4): 1280 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Keavney, J. Danesh, S. Parish, A. Palmer, S. Clark, L. Youngman, M. Delepine, M. Lathrop, R. Peto, R. Collins, et al. Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization' Int. J. Epidemiol., August 1, 2006; 35(4): 935 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Antoniades, D. Tousoulis, C. Vasiliadou, E. Stefanadi, K. Marinou, and C. Stefanadis Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction: Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction J. Am. Coll. Cardiol., May 16, 2006; 47(10): 1959 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Uitte de Willige, M. C. H. de Visser, J. J. Houwing-Duistermaat, F. R. Rosendaal, H. L. Vos, and R. M. Bertina Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen {gamma}' levels Blood, December 15, 2005; 106(13): 4176 - 4183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Smith, R. Harbord, J. Milton, S. Ebrahim, and J. A.C. Sterne Does Elevated Plasma Fibrinogen Increase the Risk of Coronary Heart Disease?: Evidence from a Meta-Analysis of Genetic Association Studies Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2228 - 2233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C.M. Jansen, E. S. van Aalst-Cohen, M. W.T. Tanck, S. Cheng, M. R. Fontecha, J. Li, J. C. Defesche, and J. J.P. Kastelein Genetic Determinants of Cardiovascular Disease Risk in Familial Hypercholesterolemia Arterioscler Thromb Vasc Biol, July 1, 2005; 25(7): 1475 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. MacCallum Markers of Hemostasis and Systemic Inflammation in Heart Disease and Atherosclerosis in Smokers Proceedings of the ATS, April 1, 2005; 2(1): 34 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mikkelsson, M. Perola, and P. J. Karhunen Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 113 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Gonzalez-Conejero, J. Rivera, J. Corral, C. Acuna, J. A. Guerrero, and V. Vicente Biological Assessment of Aspirin Efficacy on Healthy Individuals: Heterogeneous Response or Aspirin Failure? Stroke, February 1, 2005; 36(2): 276 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sass, C. Blanquart, P.-E. Morange, M. Pfister, and S. Visvikis-Siest Association Between Factor VII Polymorphisms and Blood Pressure: The Stanislas Cohort Hypertension, November 1, 2004; 44(5): 674 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bank, E. J. Libourel, S. Middeldorp, E. C. M. van Pampus, M. M. W. Koopman, K. Hamulyak, M. H. Prins, J. van der Meer, and H. R. Buller Prothrombin 20210A Mutation: A Mild Risk Factor for Venous Thromboembolism but Not for Arterial Thrombotic Disease and Pregnancy-Related Complications in a Family Study Arch Intern Med, September 27, 2004; 164(17): 1932 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Weitz, S. Middeldorp, W. Geerts, and J. A. Heit Thrombophilia and New Anticoagulant Drugs Hematology, January 1, 2004; 2004(1): 424 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Mannucci, D. Ardissino, P. A. Merlini, F. Peyvandi, Y.-G. Xie, C. Butt, and E. Randell Vagaries of genetic association studies in myocardial infarction Blood, August 15, 2003; 102(4): 1558 - 1560. [Full Text] [PDF]
|
|