on October 21, 2002
Published online before print October 21, 2002, doi: 10.1161/01.CIR.0000036597.52291.C9
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Submitted on July 18, 2002
From the Nutrition and Genomics Laboratory (J.M.O., D.C.,
O.C.), Lipid Metabolism Laboratory (E.J.S., P.C.) and the
Epidemiology Program (K.L.C.), Jean Mayer-US
Department of Agriculture Human Nutrition Research Center on Aging at
Tufts University, Boston, Mass; the Boston University School of Public
Health (S.D., L.A.C.) and School of Medicine, Boston, Mass; and the
Framingham Heart Study, Framingham, Mass
(P.W.F.W.). * To whom correspondence should be addressed. E-mail: ordovas{at}hnrc.tufts.edu.
Background—Gene-nutrient interactions affecting high-density lipoprotein cholesterol (HDL-C) concentrations may contribute to the interindividual variability of the cardiovascular disease risk associated with dietary fat intake. Hepatic lipase (HL) is a key determinant of HDL metabolism. Four polymorphisms in linkage disequilibrium have been identified in the HL gene (LIPC), defining what is known as the -514T allele. This allele has been associated with decreased HL activity and increased HDL-C concentrations. However, the effect is variable among populations. Methods and Results—We have examined interaction effects between the -514(C/T) LIPC polymorphism, dietary fat, and HDL-related measures in 1020 men and 1110 women participating in the Framingham Study. We found a consistent and highly significant gene-nutrient interaction showing a strong dose-response effect. Thus, the T allele was associated with significantly greater HDL-C concentrations only in subjects consuming <30% of energy from fat (P<0.001). When total fat intake was Conclusions—Dietary fat intake modifies the effect of the -514(C/T) polymorphism on HDL-C concentrations and subclasses. Specifically, in the Framingham Study, TT subjects may have an impaired adaptation to higher animal fat diets that could result in higher cardiovascular risk.
Revised on August 20, 2002
Accepted on August 21, 2002
Dietary Fat Intake Determines the Effect of a
Common Polymorphism in the Hepatic Lipase Gene Promoter on
High-Density Lipoprotein Metabolism. Evidence of a Strong Dose Effect in This
Gene-Nutrient Interaction in the Framingham
Study
Jose M. Ordovas PhD*,
30% of energy, mean HDL-C concentrations were lowest among those with the TT genotype, and no differences were observed between CC and CT individuals. We found similar gene-nutrient interactions when the outcome variables were HDL2-C (P<0.001), large HDL subfraction (P<0.001), or HDL size (P=0.001). These interactions were seen for saturated and monounsaturated fat intakes (highly correlated with animal fat in this population), but not for polyunsaturated fat.
Key words: lipids • lipoproteins • diet • fatty acids • genetics
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