on October 14, 2002
Circulation. 2002
Published online before print October 14, 2002, doi: 10.1161/01.CIR.0000036017.46437.02
Published online before print October 14, 2002, doi: 10.1161/01.CIR.0000036017.46437.02
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Submitted on June 14, 2002
From the Departments of Internal Medicine (Cardiology Section) (W.G.H., C.M.N., P.R., K.M.L.), Public Health Sciences (T.M.M.), and Radiology (W.G.H., C.A.H., K.M.L.), Wake Forest University School of Medicine, Winston-Salem, NC. * To whom correspondence should be addressed. E-mail: ghundley{at}wfubmc.edu.
Background—Regional assessments of left ventricular (LV) wall motion obtained during MRI cardiac stress tests can be used to identify myocardial injury and ischemia, but the utility of MRI stress test results for the assessment of cardiac prognosis is not known. Methods and Results—Two hundred seventy-nine patients referred (because of poor LV endocardial visualization with echocardiography) for dobutamine/atropine MRI for the detection of inducible ischemia were followed for an average of 20 months. After MRI stress testing, the occurrence of myocardial infarction, cardiac death, death attributable to any cause, coronary arterial revascularization, and unstable angina or congestive heart failure requiring hospitalization was determined. In a multivariate analysis, the presence of inducible ischemia (hazard ratio 3.3, CI 1.1 to 9.7) or an LV ejection fraction <40% (hazard ratio 4.2, CI 1.3 to 13.9) was associated with future MI or cardiac death independent of the presence of risk factors for coronary arteriosclerosis. Conclusions—In patients with poor echocardiograms, the results of cardiac MRI stress tests can be used to forecast myocardial infarction or cardiac death.
Revised on August 14, 2002
Accepted on August 16, 2002
Magnetic Resonance Imaging Determination of Cardiac Prognosis
W. Gregory Hundley MD*,
Key words: magnetic resonance imaging • ischemia • prognosis
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