Published Online
on September 16, 2002

A more recent version of this article appeared on October 8, 2002

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Submitted on July 18, 2002
Revised on August 15, 2002
Accepted on August 16, 2002

Missed Opportunities to Treat Atherosclerosis in Patients Undergoing Peripheral Vascular Interventions. Insights From the University of Michigan Peripheral Vascular Disease Quality Improvement Initiative (PVD-QI²)

Debabrata Mukherjee MD^*, Prasanth Lingam BS, Stanley Chetcuti MD, P. Michael Grossman MD, Mauro Moscucci MD, Ann E. Luciano RN, and Kim A. Eagle MD

From the Division of Cardiology, University of Michigan, Ann Arbor.

^* To whom correspondence should be addressed. E-mail: dmukherj{at}umich.edu.

Background—Peripheral vascular disease is a manifestation of systemic atherosclerosis and is associated with an increased risk of cardiovascular morbidity and mortality.

Methods and Results—We examined clinical outcomes in 66 consecutive patients undergoing peripheral vascular interventions at our institution between January 2001 and October 2001. At hospital discharge and at 6 months, lifestyle modifications and use of evidence-based therapy was suboptimal. At 6 months, a significant proportion continued to smoke (22.7%) and only half of the patients exercised, controlled their weight, or modified their diet for lipid control. The use of antiplatelet therapy was 77.2%; of angiotensin-converting enzyme, 35.9%; of ß-blockers, 42.5%; and of statins, 50%. Twelve of the 66 patients (18.2%) had a clinical event of death, myocardial infarction, or stroke. An appropriateness algorithm for use of secondary prevention measures was created with the use of evidence-based therapy guidelines, and a composite appropriateness variable was also created. The use of evidence-based therapy was associated with a significant reduction of the composite of death, myocardial infarction, and stroke at 6 months (OR 0.02, 95% CI 0.01 to 0.44, P=0.01).

Conclusions—Atherosclerosis risk factors are very prevalent in patients with peripheral vascular disease, but these patients receive less than optimal treatment after a predominantly technical vascular intervention. Effective secondary prevention with appropriate lifestyle interventions and evidence-based medical therapy needs to be strongly encouraged and implemented in these patients.

Key words: hypertension • peripheral vascular disease • atherosclerosis • risk factors

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