on September 16, 2002
Published online before print September 16, 2002, doi: 10.1161/01.CIR.0000034447.02535.D5
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Submitted on May 6, 2002
From Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (M.D., P.W.S., D.P.F., K.T., E.R., J.V., P.C.S., W.J.v.d.G., M.v.d.B., P.d.F.); and Brigham and Women‘s Hospital, Boston, Mass (J.J.P.). * To whom correspondence should be addressed. E-mail: Serruys{at}card.azr.nl.
Background—Early results of sirolimus-eluting stent implantation showed a nearly complete abolition of neointimal hyperplasia. The question remains, however, whether the early promising results will still be evident at long-term follow-up. The objective of our study was to evaluate the efficiency of sirolimus-eluting stent implantation for up to 2 years of follow-up. Methods and Results—Fifteen patients with de novo coronary artery disease were treated with 18-mm sirolimus-eluting Bx-Velocity stents (Cordis) loaded with 140 µg sirolimus/cm2 metal surface area in a slow release formulation. Quantitative angiography (QCA) and intravascular ultrasound (IVUS) were performed according to standard protocol. Sirolimus-eluting stent implantation was successful in all 15 patients. During the in-hospital course, 1 patient died of cerebral hemorrhage after periprocedural administration of abciximab, and 1 patient underwent repeat stenting after 2 hours because of edge dissection that led to acute occlusion. Through 6 months and up to 2 years of follow-up, no additional events occurred. QCA analysis revealed no significant change in stent minimal lumen diameter or percent diameter stenosis, and 3-dimensional IVUS showed no significant deterioration in lumen volume. In 2 patients, additional stenting was performed because of significant lesion progression remote from the sirolimus-eluting stent. Conclusion—Sirolimus-eluting stents showed persistent inhibition of neointimal hyperplasia for up to 2 years of follow-up.
Revised on July 30, 2002
Accepted on August 5, 2002
Persistent Inhibition of Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation. Long-Term (Up to 2 Years) Clinical, Angiographic, and Intravascular Ultrasound Follow-Up
Muzaffer Degertekin MD,
Key words: stents • restenosis • ultrasonics • drugs
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