on August 12, 2002
Published online before print August 12, 2002, doi: 10.1161/01.CIR.0000027816.54430.96
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Submitted on March 29, 2002
From the Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia. * To whom correspondence should be addressed. E-mail: domenico{at}spirit.gcrc.upenn.edu.
Background—Atherosclerosis is a complex vascular inflammatory disease. Low-dose aspirin is a mainstay in the prevention of vascular complications of atherosclerosis. We wished to determine the effect of low-dose aspirin on vascular inflammation, plaque composition, and atherogenesis in LDL receptor Methods and Results—In LDL receptor Conclusions—Our results suggest that in murine atherosclerosis, low-dose aspirin suppresses vascular inflammation and increases the stability of atherosclerotic plaques, both of which, together with its antiplatelet activity, contribute to its antiatherogenic effect. We conclude that low-dose aspirin might be rationally evaluated in the progression and evolution of human atherosclerotic plaque.
Revised on June 4, 2002
Accepted on June 4, 2002
Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor
Tillmann Cyrus MD, 
Deficient Mice
deficient mice fed a high fat diet.deficient mice fed a high fat diet compared with control mice, low-dose aspirin induced a significant decrease in circulating levels and vascular formation of soluble intercellular molecule-1, monocyte chemoattractant protein-1, tumor necrosis factor-
, interleukin-12p 40, without affecting lipid levels. This was associated with significant reduction of the nuclear factor 
B activity in the aorta. Low-dose aspirin also significantly reduced the extent of atherosclerosis. Finally, aortic vascular lesions of the aspirin-treated animals showed 57% reduction (P<0.05) in the amount of macrophage cells, 77% increase in smooth muscle cells (P<0.05), and 23% increase in collagen (P<0.05).
Key words: atherosclerosis • aspirin • inflammation • plaque
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