on June 24, 2002
Published online before print June 24, 2002, doi: 10.1161/01.CIR.0000025425.20606.69
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Submitted on April 17, 2002
From the Cardiology Division (M.J.L., F.G.Y., T.L.), LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah; Norman J. Arnold School of Public Health (J.L.D., K.D.D., B.E.A.), University of South Carolina, Columbia, SC; and the Department of Exercise Science (P.D.), University of North Carolina at Greensboro, NC. * To whom correspondence should be addressed. E-mail: ldmlamon{at}ihc.com.
Background—Elevated C-reactive protein (CRP) is associated with increased coronary heart disease (CHD) risk. Cardiorespiratory fitness ("fitness") is related with lower CHD risk; however, its relationship with CRP is relatively unknown. Methods and Results—Cross-sectional associations between fitness and plasma CRP were examined among 135 African American (AA), Native American (NA), and Caucasian (CA) women (55±11 year; 28±6 kg/m2). Fitness was assessed with a maximal treadmill exercise test. Plasma CRP concentrations were determined with the Dade Behring high-sensitivity immunoassay. Geometric mean CRP levels were 0.43, 0.25, and 0.23 mg/dL, and average maximal MET levels of fitness were 7.2, 9.1, and 10 METs for AA, NA, and CA, respectively. CRP decreased across tertiles of fitness (P=0.002), increased across tertiles of BMI (P=0.0007), and varied by race (P=0.002). After adjustment for covariates, lower CRP (P<0.05) was observed across tertiles of fitness among NA and CA, but not AA. Among all women, after adjusting for race and covariates, the odds of high-risk CRP (>0.19 mg/dL) were 0.67 (95% CI=0.19 to 2.4) among fit (>6.5 METs) versus unfit women. Conclusions—The health benefits from enhanced fitness may have an antiinflammatory mechanism.
Accepted on May 21, 2002
Cardiorespiratory Fitness and C-Reactive Protein Among a Tri-Ethnic Sample of Women
Michael J. LaMonte PhD, MPH*,
Key words: exercise • C-reactive protein • coronary disease • women • inflammation
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