on May 20, 2002
Circulation. 2002
Published online before print May 20, 2002, doi: 10.1161/01.CIR.0000020548.60110.76
Published online before print May 20, 2002, doi: 10.1161/01.CIR.0000020548.60110.76
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Submitted on March 5, 2002
From the Division of Cardiovascular Medicine (J.H.F.R., H.A.J., P.L.W.), Division of Stroke Medicine (E.A.W.), Wolfson Brain Imaging Centre (T.D.F., J.C.C., J.D.P.), Department of Radiology (N.A.), Clinical Pharmacology Unit (P.J., A.P.D.), Division of Neurosurgery (P.J.K.), and Centre for Applied Medical Statistics (B.N.A), University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. * To whom correspondence should be addressed. E-mail: plw{at}mole.bio.cam.ac.uk.
Background—Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but no indication of plaque inflammation. The glucose analogue [18F]-fluorodeoxyglucose (18FDG) can be used to image inflammatory cell activity non-invasively by PET. In this study we tested whether 18FDG-PET imaging can identify inflammation within carotid artery atherosclerotic plaques. Methods and Results—Eight patients with symptomatic carotid atherosclerosis were imaged using 18FDG-PET and co-registered CT. Symptomatic carotid plaques were visible in 18FDG-PET images acquired 3 hours post-18FDG injection. The estimated net 18FDG accumulation rate (plaque/integral plasma) in symptomatic lesions was 27% higher than in contralateral asymptomatic lesions. There was no measurable 18FDG uptake into normal carotid arteries. Autoradiography of excised plaques confirmed accumulation of deoxyglucose in macrophage-rich areas of the plaque. Conclusions—This study demonstrates that atherosclerotic plaque inflammation can be imaged with 18FDG-PET, and that symptomatic, unstable plaques accumulate more 18FDG than asymptomatic lesions.
Revised on April 19, 2002
Accepted on April 22, 2002
Imaging Atherosclerotic Plaque Inflammation With [18F]-Fluorodeoxyglucose Positron Emission Tomography
J. H.F. Rudd MD, MRCP,
Key words: atherosclerosis • imaging • nuclear medicine
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S. Warach and J.-C. Baron Neuroimaging Stroke, February 1, 2004; 35(2): 351 - 353. [Full Text] [PDF]
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P. J. Slomka Software Approach to Merging Molecular with Anatomic Information J. Nucl. Med., January 1, 2004; 45(90010): 36S - 45. [Abstract] [Full Text] [PDF]
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M. Tatsumi, C. Cohade, Y. Nakamoto, and R. L. Wahl Fluorodeoxyglucose Uptake in the Aortic Wall at PET/CT: Possible Finding for Active Atherosclerosis Radiology, December 1, 2003; 229(3): 831 - 837. [Abstract] [Full Text] [PDF]
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 C J S Price, E A Warburton, and D K Menon Human cellular inflammation in the pathology of acute cerebral ischaemia J. Neurol. Neurosurg. Psychiatry, November 1, 2003; 74(11): 1476 - 1484. [Abstract] [Full Text] [PDF]
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M. Levin, O. Leppanen, M. Evaldsson, O. Wiklund, G. Bondjers, and T. Bjornheden Mapping of ATP, Glucose, Glycogen, and Lactate Concentrations Within the Arterial Wall Arterioscler Thromb Vasc Biol, October 1, 2003; 23(10): 1801 - 1807. [Abstract] [Full Text] [PDF]
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E. M. Tuzcu and P. Schoenhagen Acute coronary syndromes, plaque vulnerability,and carotid artery disease: The changing role ofatherosclerosis imaging J. Am. Coll. Cardiol., September 17, 2003; 42(6): 1033 - 1036. [Full Text] [PDF]
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 R. A Yeretsian, T. M. Blodgett, B. F Branstetter IV, M. M Roberts, and C. C. Meltzer Teflon-Induced Granuloma: A False-Positive Finding with PET Resolved with Combined PET and CT AJNR Am. J. Neuroradiol., June 1, 2003; 24(6): 1164 - 1166. [Abstract] [Full Text] [PDF]
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