on May 6, 2002
Circulation. 2002
Published online before print May 6, 2002, doi: 10.1161/01.CIR.0000018948.95175.03
Published online before print May 6, 2002, doi: 10.1161/01.CIR.0000018948.95175.03
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Submitted on February 27, 2002
From the Mayo Clinic Rochester, Rochester,
Minn. * To whom correspondence should be addressed. E-mail: somers.virend{at}mayo.edu.
Background—Obstructive sleep apnea (OSA) has been increasingly linked to cardiovascular and cerebrovascular disease. Inflammatory processes associated with OSA may contribute to cardiovascular morbidity in these patients. We tested the hypothesis that OSA patients have increased plasma C-reactive protein (CRP). Methods and Results—We studied 22 patients (18 males and 4 females) with newly diagnosed OSA, who were free of other diseases, had never been treated for OSA, and were taking no medications. We compared CRP measurements in these patients to measurements obtained in 20 control subjects (15 males and 5 females) who were matched for age and body mass index, and in whom occult OSA was excluded. Plasma CRP levels were significantly higher in patients with OSA than in controls (median [range] 0.33 [0.09 to 2.73] versus 0.09 [0.02 to 0.9] mg/dL, P<0.0003). In multivariate analysis, CRP levels were independently associated with OSA severity (F=6.8, P=0.032). Conclusions—OSA is associated with elevated levels of CRP, a marker of inflammation and of cardiovascular risk. The severity of OSA is proportional to the CRP level.
Revised on April 8, 2002
Accepted on April 8, 2002
Elevated C-Reactive Protein in Patients With Obstructive Sleep Apnea
Abu S.M. Shamsuzzaman MBBS, PhD,
Key words: sleep • inflammation • cardiovascular disease • risk factors
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A. S. Gami, G. Pressman, S. M. Caples, R. Kanagala, J. J. Gard, D. E. Davison, J. F. Malouf, N. M. Ammash, P. A. Friedman, and V. K. Somers Association of Atrial Fibrillation and Obstructive Sleep Apnea Circulation, July 27, 2004; 110(4): 364 - 367. [Abstract] [Full Text] [PDF]
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U. Hatipoglu and I. Rubinstein Inflammation and Obstructive Sleep Apnea Syndrome: How Many Ways Do I Look at Thee? Chest, July 1, 2004; 126(1): 1 - 2. [Full Text] [PDF]
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 I. Jialal, S. Devaraj, and S. K. Venugopal C-Reactive Protein: Risk Marker or Mediator in Atherothrombosis? Hypertension, July 1, 2004; 44(1): 6 - 11. [Abstract] [Full Text] [PDF]
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A. S. Gami, A. Svatikova, R. Wolk, E. J. Olson, C. J. Duenwald, A. S. Jaffe, and V. K. Somers Cardiac Troponin T in Obstructive Sleep Apnea Chest, June 1, 2004; 125(6): 2097 - 2100. [Abstract] [Full Text] [PDF]
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 R. Tauman, A. Ivanenko, L. M. O'Brien, and D. Gozal Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing Pediatrics, June 1, 2004; 113(6): e564 - e569. [Abstract] [Full Text]
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A. S.M. Shamsuzzaman, M. Winnicki, R. Wolk, A. Svatikova, B. G. Phillips, D. E. Davison, P. B. Berger, and V. K. Somers Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans Circulation, May 11, 2004; 109(18): 2181 - 2185. [Abstract] [Full Text] [PDF]
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O. Milleron, R. Pilliere, A. Foucher, F. de Roquefeuil, P. Aegerter, G. Jondeau, B. G Raffestin, and O. Dubourg Benefits of obstructive sleep apnoea treatment in coronary artery disease: a long-term follow-up study Eur. Heart J., May 1, 2004; 25(9): 728 - 734. [Abstract] [Full Text] [PDF]
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S. Teramoto, H. Yamamoto, Y. Ouchi, K.-i. Inoue, H. Takano, and T. Yoshika Increased Plasma Interleukin-6 Is Associated With the Pathogenesis of Obstructive Sleep Apnea Syndrome Chest, May 1, 2004; 125(5): 1964 - 1965. [Full Text] [PDF]
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G J Gibson Sleep disordered breathing and the outcome of stroke Thorax, May 1, 2004; 59(5): 361 - 363. [Full Text] [PDF]
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S. F. Quan and B. J. Gersh Cardiovascular Consequences of Sleep-Disordered Breathing: Past, Present and Future: Report of a Workshop From the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute Circulation, March 2, 2004; 109(8): 951 - 957. [Full Text] [PDF]
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T. Altay, E. R. Gonzales, T. S. Park, and J. M. Gidday Cerebrovascular inflammation after brief episodic hypoxia: modulation by neuronal and endothelial nitric oxide synthase J Appl Physiol, March 1, 2004; 96(3): 1223 - 1230. [Abstract] [Full Text] [PDF]
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H. K. Meier-Ewert, P. M. Ridker, N. Rifai, M. M. Regan, N. J. Price, D. F. Dinges, and J. M. Mullington Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk J. Am. Coll. Cardiol., February 18, 2004; 43(4): 678 - 683. [Abstract] [Full Text] [PDF]
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P. Lavie Pro: Sleep Apnea Causes Cardiovascular Disease Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 147 - 148. [Full Text] [PDF]
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G. Sampol, O. Romero, A. Salas, J. L. Tovar, P. Lloberes, T. Sagales, and A. Evangelista Obstructive Sleep Apnea and Thoracic Aorta Dissection Am. J. Respir. Crit. Care Med., December 15, 2003; 168(12): 1528 - 1531. [Abstract] [Full Text] [PDF]
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R. Wolk, A. S.M. Shamsuzzaman, and V. K. Somers Obesity, Sleep Apnea, and Hypertension Hypertension, December 1, 2003; 42(6): 1067 - 1074. [Abstract] [Full Text] [PDF]
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A. V. Chobanian, G. L. Bakris, H. R. Black, W. C. Cushman, L. A. Green, J. L. Izzo Jr, D. W. Jones, B. J. Materson, S. Oparil, J. T. Wright Jr, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Hypertension, December 1, 2003; 42(6): 1206 - 1252. [Abstract] [Full Text] [PDF]
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