Published Online
on April 1, 2002

A more recent version of this article appeared on April 23, 2002

This Article Full Text (PDF) All Versions of this Article: 105/16/1904    most recent 01.CIR.0000014969.85364.9Fv1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rice, T. Articles by Rao, D. C. Search for Related Content PubMed Articles by Rice, T. Articles by Rao, D. C. Related Collections Lipids Quantitative modeling Exercise/exercise testing/rehabilitation Epidemiology Genetics of cardiovascular disease

Submitted on October 19, 2001
Revised on February 13, 2002
Accepted on February 14, 2002

Familial Aggregation of Blood Lipid Response to Exercise Training in the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study

Treva Rice PhD^*, Jean-Pierre Després PhD, Louis Pérusse PhD, Yuling Hong MD, PhD, Michael A. Province PhD, Jean Bergeron MD, MSc, Jacques Gagnon PhD, Arthur S. Leon MD, James S. Skinner PhD, Jack H. Wilmore PhD, Claude Bouchard PhD, and D. C. Rao PhD

From the Division of Biostatistics (T.R., Y.H., M.A.P., D.C.R.) and Departments of Genetics and Psychiatry (D.C.R.), Washington University School of Medicine, St Louis, Mo; Physical Activity Sciences Laboratory (J.-P.D., L.P.), Lipid Research Center (J.-P.D., J.B.), and Molecular Endocrinology Laboratory (J.G.), Laval University, Québec, Canada; School of Kinesiology and Leisure Studies (A.S.L.), University of Minnesota, Minneapolis; Department of Kinesiology (J.S.S.), Indiana University, Bloomington, Ind; Department of Health and Kinesiology (J.H.W.), Texas A&M University, College Station, Tex; and Pennington Biomedical Research Center (C.B.), Baton Rouge, La.

^* To whom correspondence should be addressed. E-mail: treva{at}wubios.wustl.edu.

Background—Fasting levels of plasma lipids and lipoproteins are reported to improve with regular exercise training. However, little is known on whether the training responses are influenced by heritable factors.

Methods and Results—The lipid profile was assessed in 115 black (224 individuals) and 99 white families (469 individuals), who participated in the HERITAGE Family Study, while in a sedentary state (baseline visit) and after exercise training for 20 weeks (post visit). Variables included total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I, and HDL-C subfractions 2 (HDL₂-C) and 3 (HDL₃-C). Familial correlations for the training responses (=post-baseline) were significant for most variables, and the percent variance accounted for by familial factors (ie, maximal heritabilities) ranged from 25% to 38%. Exceptions were for higher heritabilities near 60% for ApoB in blacks and HDL₂-C in whites and a lower estimate of zero for LDL-C in blacks.

Conclusions—Heritable factors in part determine lipid profile responses to regular exercise. Maximal heritabilities were similar across ethnic groups and variables, except for LDL-C, ApoB, and HDL₂-C. Molecular studies to identify the markers and genes associated with these influences are currently underway.

Key words: genetics • heritability • lipids • exercise

This article has been cited by other articles:

				S. Mora, R. F. Redberg, Y. Cui, M. K. Whiteman, J. A. Flaws, A. R. Sharrett, and R. S. Blumenthal Ability of Exercise Testing to Predict Cardiovascular and All-Cause Death in Asymptomatic Women: A 20-Year Follow-up of the Lipid Research Clinics Prevalence Study JAMA, September 24, 2003; 290(12): 1600 - 1607. [Abstract] [Full Text] [PDF]

				D. Sviridov, B. Kingwell, A. Hoang, A. Dart, and P. Nestel Single session exercise stimulates formation of pre{beta}1-HDL in leg muscle J. Lipid Res., March 1, 2003; 44(3): 522 - 526. [Abstract] [Full Text] [PDF]