Circulation. 2008;118:S_892
(Circulation. 2008;118:S_892.)
© 2008 American Heart Association, Inc.
Abstract 4454: The Influence of Anemia After Percutaneous Coronary Intervention on Clinical Outcomes
Sudhakar Sattur1;
Kishore J Harjai2;
Arvin Narula2;
Srinivas Devarakonda2;
Pamela Orshaw2;
Karl Yaeger2
1 Univ of Arizona, Tucson, AZ
2 Guthrie Health System, Sayre, PA
Although the consequences of bleeding after percutaneous coronary intervention (PCI) are well documented, there are no data on the impact of post-PCI anemia (PPA) on clinical outcomes. We evaluated the incidence, predictors, and prognostic implications of PPA on clinical outcomes in 1415 PCI procedures. We compared clinical outcomes of patients with PPA (i.e. nadir post-PCI hemoglobin < 10 gm/dL) versus without PPA. In patients with PPA, we assessed the influence of TIMI (major or minor) bleeding, drop in hemoglobin by 
3gm/dL, and use of blood transfusions on outcomes. PPA developed in 124 (8.8%) patients. Of these, 50 (40%) suffered TIMI (major or minor) bleeding, 68 (55%) had a hemoglobin drop of 3 gm/dL, and 39 (32%) patients received blood transfusions. Compared to patients without PPA, those with PPA had greater incidence of 6-month death (6.5 vs 1.7 %, p = 0.003), 6-month MACE (death, reinfarction or target vessel revascularization; 27.3 vs 14.5%, p = 0.0006), and long term mortality (25.8 vs 8.7 %, p 
0.0001). After adjustment for baseline differences, PPA showed an independent association with 6-month MACE (odds ratio 2.4, CI 1.5–3.9) and long-term mortality (hazard ratio 1.3, CI 1.0 –1.6). In patients who developed PPA, the occurrence of TIMI (major or minor) bleeding, hemoglobin drop of 3gm/dL and use of blood transfusions did not impact outcomes. In conclusion, we found that PPA is common, occurs frequently in the absence of bleeding or significant drop in hemoglobin, and connotes poor long-term outcomes.
