Circulation. 2008;118:S_1056
(Circulation. 2008;118:S_1056.)
© 2008 American Heart Association, Inc.
Cardiac and Vascular Dysfunction in Children with Heart Disease |
Abstract 6077: Advanced "Vascular Age" in Children with Dyslipidemia
Joseph Le1;
Menees Spencer1;
David McCrary2;
Danna Zhang3;
Chen Jie3;
Geetha Raghuveer4
1 Univ of Missouri Kansas City Sch of Medicine, Kansas City, MO
2 Children’s Mercy Hosp, Kansas City, MO
3 Univ of Missouri Kansas City, Kansas City, MO
4 Children’s Mercy Hosp, Kansas City, MO
Childhood obesity is a public health problem and its associated morbidities can result in advanced vascular age (VA). VA calculated using carotid intima-media thickness (CIMT) is advanced in obese children. A method for assessing burden of atherosclerosis may be determining VA by measuring CIMT. 70 high-risk children, aged 6 –19 years, underwent a carotid artery ultrasound scan using a high resolution probe. CIMT was calculated from multiple frames of the far wall of the commom carotid artery 2 cm proximal to the bifurcation using a semi-automated edge detection software. CIMT was used to gauge the child’s VA by comparing to CIMT percentile tables published for race and sex-matched adult population. Chronological age was 13.0±3.3 years. 62 (89%) were white, 34 (49%) were males. 41(59%) had a weight >95thile for age (64.0±23.4 kg). 40 (57%) had a body mass index (BMI) >95thile for age (25.6±6.0 kg/m2). 23 (33%) had systolic blood pressures (SBP) >95thile for sex, age and height (119.9±14.1 mmHg). Fasting lipid profile: total cholesterol 223.4±57.5 mg/dL, triglyceride 151.9±105.4 mg/dL, LDL cholesterol 149.8±59.0 mg/dL, HDL cholesterol 46.3±13.4 mg/dL, non-HDL cholesterol 177.1±54.6 mg/dL. Mean CIMT was 0.45±0.03 mm, maximum CIMT was 0.75 mm. By multiple regression analysis weight, BMI, & SBP were significant predictors of mean CIMT. Children with high fasting triglyceride levels were more likely to have an advanced vascular age. figure VA is advanced in children with obesity and risk factors and this association is strongest in children with high fasting triglyceride levels.
