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(Circulation. 2008;118:S_1021.)
© 2008 American Heart Association, Inc.

Diastolic Heart Failure: Diagnosis, Mechanisms and Comorbidities

Abstract 5880: Serum Resistin Concentrations and Risk of New Onset Heart Failure in the Elderly

Vasiliki V Georgiopoulou¹; Andreas P Kalogeropoulos¹; Nathalie de Rekeneire²; Nicolas Rodondi³; Andrew L Smith⁴; Udo Hoffmann⁵; Alka Kanaya⁶; Anne B Newman⁷; Stephen B Kritchevsky⁸; Ramachandran S Vasan⁹; Peter W Wilson¹⁰; Tamara B Harris¹¹; Javed Butler¹²

¹ Emory Univ, Atlanta, GA
² EpiCntr, Paris, France
³ Univ of Lausanne, Lausanne, Switzerland
⁴ Emory Univ, Atlanta, GA
⁵ Massachusetts General Hosp, Boston, MA
⁶ Univ of California San Francisco, San Francisco, CA
⁷ Univ of Pittsburgh, Pittsburgh, PA
⁸ Wake Forest Univ, Winston Salem, SC
⁹ Boston Univ, Boston, MA
¹⁰ Emory Univ, Atlanta, GA
¹¹ National Institute of Aging, Bethesda, MD
¹² Emory Univ, Atlanta, GA

Resistin, a novel adipocytokine, is associated with inflammation and insulin resistance; both mechanisms are known to increase risk for heart failure (HF). We studied 2904 older persons without HF (age 73.3±2.8 years, 47.9% men, 58.6% whites) enrolled in the Health ABC study who underwent serum resistin measurements at baseline. Participants were divided into groups based on tertiles of resistin concentrations and rates of incident HF (defined as hospitalization for new onset HF) were compared by Cox proportional hazards models. After 7.1 year median follow-up 252 participants (8.7%) developed HF. Increasing resistin concentrations were significantly associated with increasing incident HF rates (Figure 1). After adjusting for baseline differences (including body mass index) and predictors of incident HF (age, coronary disease, smoking, blood pressure, heart rate, serum glucose, creatinine, and albumin concentrations, and left ventricular hypertrophy), serum resistin concentrations were independently associated with incident HF [highest vs. lowest tertile hazard ratio (HR) 1.96, 95% confidence interval (CI) 1.35–2.82). Further adjustment for markers of inflammation (Creactive protein, interleukin-6, and tumor necrosis factor ) and of insulin resistance (fasting insulin level and hemoglobin A1c) only moderately attenuated this association which remained significant (HR 1.67, 95% CI 1.13–2.60). These findings were consistent in both sexes and among whites and blacks. High serum resistin concentrations are independently associated with increasedrisk for HF. Further studies are needed to confirm these findings.

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Georgiopoulou, V. V Articles by Butler, J. PubMed Articles by Georgiopoulou, V. V Articles by Butler, J.