Circulation. 2007;116:1107
doi: 10.1161/CIRCULATIONAHA.107.185629
(Circulation. 2007;116:1107.)
© 2007 American Heart Association, Inc.
Issue Highlights
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AORTIC DIAMETER  5.5 CM IS NOT A GOOD PREDICTOR OF TYPE A AORTIC DISSECTION: OBSERVATIONS FROM THE INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION (IRAD), by Pape et al
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In this week’s issue of
Circulation, Pape et al use data
from the International Registry of Acute Aortic Dissection (IRAD)
to investigate the relationship between aortic diameter and
type A dissection. The investigators examined 591 type A dissection
patients between 1996 and 2005 and found that nearly 60% of
those evaluated had diameters <5.5 cm and that 40% had diameters
<5.0 cm. Therefore, the authors concluded that the majority
of patients with acute type A aortic dissection present with
aortic diameters <5.5 cm and do not fall within current guidelines
for elective aneurysm surgery. Although descriptive, this study
suggests that alternatives to aortic size need to be assessed
as predictors for identifying patients at risk for aortic dissection.
See p
1120.
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OFF-PUMP VERSUS ON-PUMP CORONARY ARTERY BYPASS GRAFT SURGERY: DIFFERENCES IN SHORT-TERM OUTCOMES AND IN LONG-TERM MORTALITY AND NEED FOR SUBSEQUENT REVASCULARIZATION, by Hannan et al
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Off-pump coronary artery bypass graft surgery is now common,
but there remains much uncertainty about whether it achieves
better patient outcomes than the traditional approach, particularly
in routine practice. To address this issue, Hannan and colleagues
compare the experience of 13 899 patients who underwent off-pump
coronary artery bypass graft surgery in New York from 2001 to
2004 with 35 941 patients who had on-pump surgery. They assessed
mortality at up to 3 years after surgery and also complication
rates and subsequent revascularization procedures. They employ
a propensity analysis to minimize bias. The findings do not
definitely favor one approach over the other but illuminate
the trade-offs that should be considered in making the choice.
See p
1145.
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BONE MARROW–DERIVED CELLS ARE INVOLVED IN THE PATHOGENESIS OF CARDIAC HYPERTROPHY IN RESPONSE TO PRESSURE OVERLOAD, by Endo et al
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In this issue of
Circulation, Endo et al investigate the association
between hypertrophy and the incorporation of bone marrow cells
in the heart using mouse models where bone marrow cells are
tagged with a fluorescent marker protein. Bone marrow–derived
cells expressing cardiac myocyte–specific marker proteins
appeared predominantly in the right ventricle under stress that
promotes pulmonary hypertension and predominantly in the left
ventricle after transverse aortic constriction. Using donor
cells from mice that express the Cre recombinase from a cardiac-specific
promoter, the investigators showed that the differentiation
of the bone marrow cells predominantly resulted from their fusion
with recipient cardiac cells. In addition, another subset of
bone marrow–derived cells expressing both immune cell
and smooth muscle cell markers was found in fibrotic regions
of the heart. Whereas most studies have highlighted the protective
aspects of progenitor cells in the heart, these data raise concerns
that bone marrow–derived progenitor cells may contribute
to the pathological phenotype associated with cardiac hypertrophy.
See p
1176.
Visit http://circ.ahajournals.org/
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Special Report
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Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and
Recommendations for Future Research: A Report From the National
Heart, Lung, and Blood Institute and Office of Dietary Supplements
Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis
Workshop. See p
e320.
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Images in Cardiovascular Medicine
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Sclerotic Aortic Valve: Flow-Sensitive 4-Dimensional Magnetic
Resonance Imaging Reveals 3 Distinct Flow-Pattern Changes. See
p
e336.
Tissue Diagnosis With Magnetic Resonance Imaging. See p e338.
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Correspondence
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See p
e339.
Related Articles:
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Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research: A Report from the National Heart, Lung, and Blood Institute and Office of Dietary Supplements Omega-3 Fatty Acids and Their Role in Cardiac Arrhythmogenesis Workshop
- Barry London, Christine Albert, Mark E. Anderson, Wayne R. Giles, David R. Van Wagoner, Ethan Balk, George E. Billman, Mei Chung, William Lands, Alexander Leaf, John McAnulty, Jeffrey R. Martens, Rebecca B. Costello, and David A. Lathrop
Circulation 2007 116: e320-e335.
[Full Text]
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Sclerotic Aortic Valve: Flow-Sensitive 4-Dimensional Magnetic Resonance Imaging Reveals 3 Distinct Flow-Pattern Changes
- Michael Markl, Andreas Harloff, Daniela Föll, Mathias Langer, Jürgen Hennig, and Alex Frydrychowicz
Circulation 2007 116: e336-e337.
[Full Text]
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Tissue Diagnosis With Magnetic Resonance Imaging
- Subha V. Raman, Ashfaq Ahmed, Orlando P. Simonetti, and Juan Crestanello
Circulation 2007 116: e338.
[Full Text]
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Letter Regarding Article, "Glucose Levels Predict Hospitalization for Congestive Heart Failure in Patients at High Cardiovascular Risk"
- George I. Varughese, Abd A. Tahrani, and John H.B. Scarpello
Circulation 2007 116: e339.
[Full Text]
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Bone Marrow–Derived Cells Are Involved in the Pathogenesis of Cardiac Hypertrophy in Response to Pressure Overload
- Jin Endo, Motoaki Sano, Jun Fujita, Kentaro Hayashida, Shinsuke Yuasa, Naoki Aoyama, Yuji Takehara, Osamu Kato, Shinji Makino, Satoshi Ogawa, and Keiichi Fukuda
Circulation 2007 116: 1176-1184.
[Abstract]
[Full Text]
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Off-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery: Differences in Short-Term Outcomes and in Long-Term Mortality and Need for Subsequent Revascularization
- Edward L. Hannan, Chuntao Wu, Craig R. Smith, Robert S.D. Higgins, Russell E. Carlson, Alfred T. Culliford, Jeffrey P. Gold, and Robert H. Jones
Circulation 2007 116: 1145-1152.
[Abstract]
[Full Text]
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Aortic Diameter 5.5 cm Is Not a Good Predictor of Type A Aortic Dissection: Observations From the International Registry of Acute Aortic Dissection (IRAD)
- Linda A. Pape, Thomas T. Tsai, Eric M. Isselbacher, Jae K. Oh, Patrick T. O’Gara, Arturo Evangelista, Rossella Fattori, Gabriel Meinhardt, Santi Trimarchi, Eduardo Bossone, Toru Suzuki, Jeanna V. Cooper, James B. Froehlich, Christoph A. Nienaber, Kim A. Eagle on behalf of the International Registry of Acute Aortic Dissection (IRAD) Investigators
Circulation 2007 116: 1120-1127.
[Abstract]
[Full Text]
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AORTIC DIAMETER >=5.5 CM...
OFF-PUMP VERSUS ON-PUMP CORONARY...