Circulation. 2007;115:3139
doi: 10.1161/CIRCULATIONAHA.107.183533
(Circulation. 2007;115:3139.)
© 2007 American Heart Association, Inc.
Issue Highlights
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EVALUATION OF DOSE-RELATED EFFECTS OF ASPIRIN ON PLATELET FUNCTION: RESULTS FROM THE ASPIRIN-INDUCED PLATELET EFFECT (ASPECT) STUDY, by Gurbel et al.
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Although there have been many studies examining the effect of
aspirin on platelet function, most have limitations in study
design and are associative. In this issue of
Circulation, Gurbel
and colleagues report a double-blind, double-crossover investigation
of 125 stable outpatients with coronary disease who received
3 different doses of aspirin for 4 weeks over a 12-week period.
A broad panel of cyclooxygenase-1–dependent and –independent
platelet function assays were examined. The authors found that,
while aspirin consistently blocked arachidonic acid–induced
function, the other platelet function tests demonstrated greater
estimates of resistance. These results suggest that aspirin’s
non–cyclooxygenase-1–dependent effects may contribute
to the variability in aspirin response. See p
3156.
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SUPPRESSION OF CENTRAL SLEEP APNEA BY CONTINUOUS POSITIVE AIRWAY PRESSURE AND TRANSPLANT-FREE SURVIVAL IN HEART FAILURE: A POST HOC ANALYSIS OF THE CANADIAN CONTINUOUS POSITIVE AIRWAY PRESSURE FOR PATIENTS WITH CENTRAL SLEEP APNEA AND HEART FAILURE TRIAL (CANPAP), by Arzt et al.
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The primary analysis of the Canadian Continuous Positive Airway
Pressure (CPAP) for Patients With Central Sleep Apnea and Heart
Failure Trial (CANPAP) showed no benefit on heart transplant–free
survival; however, many patients in the trial failed to achieve
the target goal of an apnea-hypopnea index <15. In a post
hoc analysis, it was found that CPAP-treated patients who obtained
a reduction in apnea-hypopnea index to <15 showed improvements
in both left ventricular ejection fraction and transplant-free
survival versus control patients. In contrast, CPAP-treated
patients who did not achieve an apnea-hypopnea index of <15
did not have improvements in either left ventricular ejection
fraction or survival. These findings suggest that CPAP therapy
sufficient to reduce apnea-hypopnea index may improve left ventricular
function and survival. See p
3173.
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CARDIAC ANGIOGRAPHY IN RENALLY IMPAIRED PATIENTS (CARE) STUDY: A RANDOMIZED DOUBLE-BLIND TRIAL OF CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH CHRONIC KIDNEY DISEASE, by Solomon et al.
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Contrast induced nephropathy (CIN) is an uncommon complication
of angiography, but it is recognized to occur much more frequently
in those patients with moderate to severe chronic kidney disease.
The choice of contrast media may also be important; several
small studies have suggested a lower incidence of CIN with the
use of a nonionic isotonic dimer contrast agent, iodixanol-320.
This multicenter randomized double-blind study was undertaken
to compare the incidence of CIN with the low-osmolar iopamidol-370
(Isovue) as compared to the iso-osmolar iodixanol-320 (Visipaque)
after diagnostic or interventional cardiac catherization in
482 patients with moderate to severe chronic kidney disease.
Serum creatinine and estimated glomerular filtration rate were
measured 2 to 5 days later. CIN, defined as an increase in serum
creatinine of >0.5 mg/dL, occurred in 4.4% of the iopamidol
group and 6.7% of the iodixanol group (
P=NS). Other measures
of CIN were also not different. The study concluded that there
was no difference in CIN between these 2 contrast agents, and
either can be used in this setting. See p
3189.
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Occurrence of Multiple Fibrofatty Replacements Exclusively in
the Left Ventricle of a Patient With Monomorphic Sustained Ventricular
Tachycardia. See p e640. Anaphylaxis and Recurrent Hydatid Disease.
See p
e643.
The Metamorphosis of the Thrombus After Thrombolytic Therapy. See p e646.
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Correspondence
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See p
e648.
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Circulation 2007 115: e643-e645.
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The Metamorphosis of the Thrombus After Thrombolytic Therapy
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Letter by Krötz et al Regarding Article, "Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure"
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Circulation 2007 115: e648.
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Cardiac Angiography in Renally Impaired Patients (CARE) Study: A Randomized Double-Blind Trial of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease
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Circulation 2007 115: 3189-3196.
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Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study
- Paul A. Gurbel, Kevin P. Bliden, Joseph DiChiara, Justin Newcomer, Willy Weng, Nagaraj K. Neerchal, Tania Gesheff, Srivasavi K. Chaganti, Amena Etherington, and Udaya S. Tantry
Circulation 2007 115: 3156-3164.
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Suppression of Central Sleep Apnea by Continuous Positive Airway Pressure and Transplant-Free Survival in Heart Failure: A Post Hoc Analysis of the Canadian Continuous Positive Airway Pressure for Patients With Central Sleep Apnea and Heart Failure Trial (CANPAP)
- Michael Arzt, John S. Floras, Alexander G. Logan, R. John Kimoff, Frederic Series, Debra Morrison, Kathleen Ferguson, Israel Belenkie, Michael Pfeifer, John Fleetham, Patrick Hanly, Mark Smilovitch, Clodagh Ryan, George Tomlinson, T. Douglas Bradley for the CANPAP Investigators
Circulation 2007 115: 3173-3180.
[Abstract]
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EVALUATION OF DOSE-RELATED...
SUPPRESSION OF CENTRAL SLEEP...