Circulation. 2006;114:1793
(Circulation. 2006;114:1793.)
© 2006 American Heart Association, Inc.
Issue Highlights
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PHOSPHODIESTERASE-5 INHIBITOR IN EISENMENGER SYNDROME: A PRELIMINARY OBSERVATIONAL STUDY, by Mukhopadhyay et al.
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The hemodynamic effects of phosphodiesterase-5 (PDE-5) inhibitors
in patients with Eisenmenger syndrome are unknown. Mukhopadhyay
and colleagues present a preliminary observational study on
the effects of tadalafil, a PDE-5 inhibitor with a half-life
of approximately 18 hours, on acute hemodynamics, tolerability,
and efficacy over a 12-week period in patients with Eisenmenger
syndrome. Pulmonary vascular resistance (PVR) fell immediately
in 13 of 16 subjects; all those who responded in the short term
had a further decline in PVR over the 12-week study period,
with less right-to-left shunting and improvement in the systemic
arterial oxygen saturation. No patients had adverse events.
This preliminary investigation, the first to assess the hemodynamic
effects of PDE-5 inhibitors in Eisenmenger syndrome, suggests
that a daily single dose of tadalafil may be effective in decreasing
PVR in selected patients with Eisenmenger syndrome. See p
1807.
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TRANSCRIPTIONAL PROFILING IN CORONARY ARTERY DISEASE: INDICATIONS FOR NOVEL MARKERS OF CORONARY COLLATERALIZATION, by Chittenden et al.
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Coronary collaterals have been shown to reduce ischemic damage;
many patients, however, do not develop sufficient collaterals.
The factors responsible for the presence or absence of collaterals
are poorly understood. Recent studies have suggested that circulating
monocytes may be important. In the study by Chittenden et al
in this issue of
Circulation, a comprehensive characterization
of monocyte transcriptome in patients with and without collaterals
was performed using high-throughput expression profiling and
redundancy-based data mining techniques. From this analysis,
molecular markers were identified. Correlative serum markers
were also determined to validate the gene expression studies.
These findings support the contention that genetic factors heavily
influence coronary collateral vessel growth in humans. See p
1811.
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ELEVATED MATRIX METALLOPROTEINASE-9 ASSOCIATED WITH STROKE OR CARDIOVASCULAR DEATH IN PATIENTS WITH CAROTID STENOSIS, by Eldrup et al.
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The last decade has produced great advances in our understanding
of vascular disease and our ability to develop biomarkers of
disease activity. In this issue of
Circulation, Eldrup and colleagues
have examined the relation between a marker of plaque vulnerability,
matrix metalloproteinase-9, and stroke. This report is significant
in that it has focused on stroke, a manifestation of cardiovascular
disease that has received relatively less attention than coronary
heart disease. See p
1847.
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Percutaneous Intervention to a Right Coronary Artery Vein Graft
Complicated by Perforation Into the Right Heart. See p
e549.
Neovascularization From Coronary Artery Leaking to Fungus Ball in the Lung. See p e551.
Hypertrophic Obstructive Cardiomyopathy: Septal Ablation With Overlapping Sirolimus-Eluting and Covered Stents After Failed Alcoholization and Concomitant Coronary Artery Disease. See p e553.
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Correspondence
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See p
e556.
Related Articles:
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Percutaneous Intervention to a Right Coronary Artery Vein Graft Complicated by Perforation Into the Right Heart
- Zoë Astroulakis and Anthony Mathur
Circulation 2006 114: e549-e550.
[Full Text]
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Neovascularization From Coronary Artery Leaking to Fungus Ball in the Lung
- Kwang Kon Koh, Seung Hwan Han, Jeong Ho Kim, Sang Jin Lee, and Jin Yong Kim
Circulation 2006 114: e551-e552.
[Full Text]
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Hypertrophic Obstructive Cardiomyopathy: Septal Ablation With Overlapping Sirolimus-Eluting and Covered Stents After Failed Alcoholization and Concomitant Coronary Artery Disease
- Georgios Sianos, Michail I. Papafaklis, Eleni C. Vourvouri, Jurgen T. Ligthart, Timo Baks, Folkert J. Ten Cate, and Patrick W. Serruys
Circulation 2006 114: e553-e555.
[Full Text]
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Letter by Krop et al Regarding Article, "Role of p90 Ribosomal S6 Kinase-Mediated Prorenin-Converting Enzyme in Ischemic and Diabetic Myocardium"
- Manne Krop, Joep H.M. van Esch, and A.H. Jan Danser
Circulation 2006 114: e556.
[Full Text]
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Elevated Matrix Metalloproteinase-9 Associated With Stroke or Cardiovascular Death in Patients With Carotid Stenosis
- Nikolaj Eldrup, Marie-Louise Moes Grønholdt, Henrik Sillesen, and Børge G. Nordestgaard
Circulation 2006 114: 1847-1854.
[Abstract]
[Full Text]
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Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome: A Preliminary Observational Study
- Saibal Mukhopadhyay, Manish Sharma, S. Ramakrishnan, Jamal Yusuf, Mohit Dayal Gupta, Naveen Bhamri, Vijay Trehan, and Sanjay Tyagi
Circulation 2006 114: 1807-1810.
[Abstract]
[Full Text]
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Transcriptional Profiling in Coronary Artery Disease: Indications for Novel Markers of Coronary Collateralization
- Thomas W. Chittenden, Jonathan A. Sherman, Fei Xiong, Amy E. Hall, Anthony A. Lanahan, Jennifer M. Taylor, Hangjun Duan, Justin D. Pearlman, Jason H. Moore, Stephen M. Schwartz, and Michael Simons
Circulation 2006 114: 1811-1820.
[Abstract]
[Full Text]
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