Circulation. 2005;112:2753
(Circulation. 2005;112:2753.)
© 2005 American Heart Association, Inc.
Issue Highlights
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PULMONARY NEOVASCULARITY: A DISTINCTIVE RADIOGRAPHIC FINDING IN EISENMENGER SYNDROME, by Sheehan et al.
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Sheehan and colleagues characterized distinctive pulmonary vascular
abnormalities seen on chest radiographs and computed tomography
(CT) scans in 24 patients with Eisenmenger syndrome, as compared
with 14 patients with acyanotic pulmonary artery hypertension
(PAH). Eisenmenger patients had distinctive features on chest
radiographs and CT scans more often than did those with acyanotic
PAH. On CT, neovascularity, lobular ground glass, and increased
systemic collaterals were identified regardless of the etiology
of PAH, although they were significantly more common in Eisenmenger
syndrome. Neovascularity and ground glass opacification were
more prevalent and more severe in post-tricuspid defects in
which pulmonary hypertension was present early in life, suggesting
that the lesions were influenced by time of onset and duration
of pulmonary vascular disease. See p
2778.
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PIOGLITAZONE REDUCES NEOINTIMA VOLUME AFTER CORONARY STENT IMPLANTATION: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL IN NONDIABETIC PATIENTS, by Marx et al.
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Thiazolidinediones (TZDs) are a class of compounds commonly
used to treat diabetes mellitus. These agents act as agonists
for the peroxisome-proliferator-activated receptor-
(PPAR-
)
nuclear receptor that controls the expression of many genes
involved in energy metabolism. Recently, in vitro and animal
studies have implicated this class of nuclear receptors in the
inflammatory response, although the applicability of these findings
to humans remains unclear. In this issue, Marx and colleagues
have advanced our knowledge of TZDs on human inflammation. Using
restenosis as a model, they investigated the efficacy of TZDs
on the response to arterial injury in a nondiabetic population.
They provide clear evidence of an antiinflammatory effect that
is independent of glucose control. See p
2792.
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MAGNETIC RESONANCE ASSESSMENT OF THE SUBSTRATE FOR INDUCIBLE VENTRICULAR TACHYCARDIA IN NONISCHEMIC CARDIOMYOPATHY, by Nazarian et al.
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A vexing issue undergoing intense scrutiny involves optimizing
selection of patients with heart failure and left ventricular
dysfunction for placement of implantable defibrillators. Markers
of risk that would allow for more efficient patient selection
would be of great interest and clinical relevance. In this issue
of
Circulation, Nazarian and colleagues focus on patients with
nonischemic dilated cardiomyopathy and hypothesize that a heterogeneous
myocardial structural substrate would be associated with a propensity
for inducible arrhythmias. Using cardiac magnetic resonance
imaging, the authors demonstrate that nontransmural distribution
of scar in this patient group was predictive of inducible ventricular
tachycardia and remained so in a multivariable model. These
biologically plausible data set the stage for further investigations
on optimizing implantable cardioverter-defibrillator selection
by this method and add to the growing body of literature on
the clinical implications of myocardial fibrosis identified
by cardiac magnetic resonance imaging in various cardiomyopathies.
See p
2821.
Visit http://www.circ.ahajournals.org:
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Cardiology Patient Page
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Palpitations. See p
e299.
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Images in Cardiovascular Medicine
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The Catch: A Graphic Demonstration of the Value of Embolic Protection
Devices. See p
e302.
Novel Magnetic Resonance-Compatible Coronary Stent: The Absorbable Magnesium-Alloy Stent. See p e303.
Dehiscence of Mitral Annuloplasty Ring. See p e305. 
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Correspondence
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See p
e306.
Related Articles:
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Pulmonary Neovascularity: A Distinctive Radiographic Finding in Eisenmenger Syndrome
- Ramon Sheehan, Joseph K. Perloff, Michael C. Fishbein, David Gjertson, and Denise R. Aberle
Circulation 2005 112: 2778-2785.
[Abstract]
[Full Text]
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Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Nonischemic Cardiomyopathy
- Saman Nazarian, David A. Bluemke, Albert C. Lardo, Menekhem M. Zviman, Stanley P. Watkins, Timm L. Dickfeld, Glenn R. Meininger, Ariel Roguin, Hugh Calkins, Gordon F. Tomaselli, Robert G. Weiss, Ronald D. Berger, João A.C. Lima, and Henry R. Halperin
Circulation 2005 112: 2821-2825.
[Abstract]
[Full Text]
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Palpitations
- Joshua M. Cooper
Circulation 2005 112: e299-e301.
[Extract]
[Full Text]
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The Catch: A Graphic Demonstration of the Value of Embolic Protection Devices
- Rajbir S. Sangha and Bruce N. Brent
Circulation 2005 112: e302.
[Extract]
[Full Text]
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Novel Magnetic Resonance-Compatible Coronary Stent: The Absorbable Magnesium-Alloy Stent
- Holger Eggebrecht, Jörg Rodermann, Peter Hunold, Axel Schmermund, Dirk Böse, Michael Haude, and Raimund Erbel
Circulation 2005 112: e303-e304.
[Extract]
[Full Text]
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Dehiscence of Mitral Annuloplasty Ring
- Adam R. Shapira, Marcus F. Stoddard, and Buddhadeb Dawn
Circulation 2005 112: e305.
[Extract]
[Full Text]
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Letter Regarding Article by Valgimigli et al, "Short- and Long-Term Clinical Outcome After Drug-Eluting Stent Implantation for the Percutaneous Treatment of Left Main Coronary Artery Disease" • Response
- Sacha Bull, Navtej Chahal, Charles J. McKenna, Marco Valgimigli, Carlos A.G. van Mieghem, Andrew T.L. Ong, Jiro Aoki, Gaston A. Rodriguez Granillo, Eugene P. McFadden, Pim J. De Feyter, Pieter C. Smits, Evelyn Regar, Willem J. Van der Giessen, George Sianos, Peter de Jaegere, Ron T. Van Domburg, Patrick W. Serruys, and Arie Pieter Kappetein
Circulation 2005 112: e306.
[Extract]
[Full Text]
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Pioglitazone Reduces Neointima Volume After Coronary Stent Implantation: A Randomized, Placebo-Controlled, Double-Blind Trial in Nondiabetic Patients
- Nikolaus Marx, Jochen Wöhrle, Thorsten Nusser, Daniel Walcher, Angelika Rinker, Vinzenz Hombach, Wolfgang Koenig, and Martin Höher
Circulation 2005 112: 2792-2798.
[Abstract]
[Full Text]
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PULMONARY NEOVASCULARITY: A...
PIOGLITAZONE REDUCES NEOINTIMA...