Circulation. 2005;111:2275
(Circulation. 2005;111:2275.)
© 2005 American Heart Association, Inc.
Issue Highlights
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CORONARY CIRCULATORY DYSFUNCTION IN INSULIN RESISTANCE, IMPAIRED GLUCOSE TOLERANCE, AND TYPE 2 DIABETES MELLITUS, by Prior et al.
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The notion that diabetes contributes importantly to the development
of atherosclerosis and cardiovascular disease has long been
known. Consistent with this notion, diabetes is also associated
with impaired vascular function, a preclinical marker of atherosclerosis.
However, the extent to which impaired glucose tolerance and
insulin resistance are also injurious to the vasculature is
not known. In this issue, Prior and colleagues examine vascular
function across the entire spectrum of insulin resistance and
diabetes. They report that vascular dysfunction is present very
early in the process toward development of diabetes, and they
highlight the notion that insulin resistance makes a strong
contribution to the development of vascular disease. See p
2291.
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CONTRIBUTIONS OF DEPRESSIVE MOOD AND CIRCULATING INFLAMMATORY MARKERS TO CORONARY HEART DISEASE IN HEALTHY EUROPEAN MEN: THE PROSPECTIVE EPIDEMIOLOGICAL STUDY OF MYOCARDIAL INFARCTION (PRIME), by Empana et al.
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Depressive symptoms are associated with worse prognosis in patients
with coronary heart disease. Some investigators have suggested
that the relationship might be mediated by inflammation. In
a prospective, observational study that seeks to identify risk
factors for coronary heart disease and explain the gradient
in risk between Belfast and France, investigators studied 335
individuals who subsequently developed a first ischemic coronary
event and 670 age and center-matched controls to determine the
relationship between depressive symptoms and markers of inflammation
on this risk of angina pectoris, nonfatal myocardial infarction,
and coronary death. This study provides some insight about whether
the association of depressive symptoms with outcomes in this
population is explained by the levels of their inflammatory
markers. See p
2299.
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LEFT VENTRICULAR SYSTOLIC PERFORMANCE, FUNCTION, AND CONTRACTILITY IN PATIENTS WITH DIASTOLIC HEART FAILURE, by Baicu et al.
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Clinical heart failure in a patient with a normal left ventricular
ejection fraction is referred to as diastolic heart failure.
It has been assumed that abnormalities of diastolic filling
are the major cause of heart failure in such patients. However,
it has been controversial as to whether systolic dysfunction
also contributed to hemodynamic dysfunction is such patients.
Baicu et al address this issue by measuring systolic function
in 75 patients who met the criteria for diastolic heart failure
and 75 subjects without cardiovascular disease. They found that
several noninvasive and invasive indices of systolic function
were normal or even increased in the patients with diastolic
heart failure, leading to the conclusion that the pathophysiology
of diastolic heart failure is not related to significant abnormalities
in systolic function. See p
2306.
Visit http://www.circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Leaflet Fracture of a St. Jude Mechanical Bileaflet Valve. See
p
e280.
Fast and Complete Healing of 2 Coronary Artery Spontaneous Dissections. See p e282.
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Book Review
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The Expert Guide to Beating Heart Disease: What You Absolutely
Must Know. See p
e283.
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Correspondence
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See p
e284.
Related Articles:
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Contributions of Depressive Mood and Circulating Inflammatory Markers to Coronary Heart Disease in Healthy European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME)
- J.P. Empana, D.H. Sykes, G. Luc, I. Juhan-Vague, D. Arveiler, J. Ferrieres, P. Amouyel, A. Bingham, M. Montaye, J.B. Ruidavets, B. Haas, A. Evans, X. Jouven, P. Ducimetiere for the PRIME Study Group
Circulation 2005 111: 2299-2305.
[Abstract]
[Full Text]
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Coronary Circulatory Dysfunction in Insulin Resistance, Impaired Glucose Tolerance, and Type 2 Diabetes Mellitus
- John O. Prior, Manuel J. Quiñones, Miguel Hernandez-Pampaloni, Alvaro D. Facta, Thomas H. Schindler, James W. Sayre, Willa A. Hsueh, and Heinrich R. Schelbert
Circulation 2005 111: 2291-2298.
[Abstract]
[Full Text]
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Left Ventricular Systolic Performance, Function, and Contractility in Patients With Diastolic Heart Failure
- Catalin F. Baicu, Michael R. Zile, Gerard P. Aurigemma, and William H. Gaasch
Circulation 2005 111: 2306-2312.
[Abstract]
[Full Text]
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Leaflet Fracture of a St. Jude Mechanical Bileaflet Valve
- A. Mosterd, G.M.M. Shahin, W.J. van Boven, W. Jaarsma, A.D. Graafland, and H.A. van Swieten
Circulation 2005 111: e280-e281.
[Full Text]
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Fast and Complete Healing of 2 Coronary Artery Spontaneous Dissections
- Daniela Trabattoni, Alfreda Calligaris, and Antonio L. Bartorelli
Circulation 2005 111: e282.
[Full Text]
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The Expert Guide to Beating Heart Disease: What You Absolutely Must Know
- Rodman D. Starke
Circulation 2005 111: e283.
[Full Text]
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Letter Regarding Article by Tsimikas et al, "High-Dose Atorvastatin Reduces Total Plasma Levels of Oxidized Phospholipids and Immune Complexes Present on Apolipoprotein B-100 in Patients With Acute Coronary Syndromes in the MIRACL Trial" • Response
- Lambertus J. van Tits, Jacqueline de Graaf, Anton F. Stalenhoef, Sotirios Tsimikas, Joseph L. Witztum, Elizabeth R. Miller, William J. Sasiela, Michael Szarek, Anders G. Olsson, and Gregory G. Schwartz
Circulation 2005 111: e284-e285.
[Full Text]
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CORONARY CIRCULATORY DYSFUNCTION...
CONTRIBUTIONS OF DEPRESSIVE MOOD...