Circulation. 2005;111:1729
(Circulation. 2005;111:1729.)
© 2005 American Heart Association, Inc.
Issue Highlights
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ANTIOXIDATIVE EFFECTS OF EXERCISE TRAINING IN PATIENTS WITH CHRONIC HEART FAILURE: INCREASE IN RADICAL SCAVENGER ENZYME ACTIVITY IN SKELETAL MUSCLE, by Linke et al.
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Exercise training improves functional capacity in patients with
heart failure. This has been explained, in part, due to improvement
in endothelial function leading to increased perfusion of the
exercising skeletal muscles. Local oxidative stress is known
to impair endothelial function. In this issue of
Circulation,
Linke et al evaluate whether exercise training reduces oxidative
stress in patients with heart failure. In this controlled trial,
6 months of moderate-intensity exercise augmented the activity
of the radical scavenger enzymes superoxide dismutase, catalase,
and glutathione peroxidase and decreased oxidative stress, as
measured by nitrotyrosine formation, in the skeletal muscle.
In their elegant study, these authors have further elucidated
important mechanisms by which exercise training is beneficial
to patients with heart failure. See p
1763.
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PROGNOSTIC VALUE OF AMBULATORY AND HOME BLOOD PRESSURES COMPARED WITH OFFICE BLOOD PRESSURE IN THE GENERAL POPULATION: FOLLOW-UP RESULTS FROM THE PRESSIONI ARTERIOSE MONITORATE E LORO ASSOCIAZIONI (PAMELA) STUDY, by Sega et al.
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Ambulatory and home blood pressure measurement is often promoted
as having greater prognostic importance than office-based measurement.
In a general population, however, whether it is worth the extra
effort to obtain ambulatory or home blood pressure measurement
remains controversial. Investigators from Italy, using data
from the PAMELA study, were able to compare the prognostic importance
of ambulatory, home, and office blood pressure measurements
for the risk of mortality in 2051 subjects who were followed
up for an average of 131 months. The study provides evidence
about whether a more comprehensive blood pressure measurement
strategy applied to the general population would yield greater
information about patients’ risk levels. See p
1777.
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HOMOZYGOSITY FOR FACTOR V LEIDEN LEADS TO ENHANCED THROMBOSIS AND ATHEROSCLEROSIS IN MICE, by Eitzman et al.
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Among patients presenting with venous thrombosis, the presence
of factor V Leiden has proven to be quite prevalent. Despite
this well-known association, it is not clear if the presence
of this genetic mutation has a material impact on arterial thrombosis.
This question has been addressed in this issue via a mouse model.
The investigators found that factor V Leiden was associated
with a predilection to thrombosis. More importantly, however,
this study was also able to address the source of factor V Leiden
using a strategy of bone marrow transplantation. These data
enhance our understanding of how factor V Leiden produces a
predisposition to vascular thrombosis and the source(s) of factor
V Leiden that cause this defect. See p
1822.
Visit www.circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Inverted Left Atrial Appendage Ligation Mimicking Thrombus.
See p
e178.
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Correspondence
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Letter Regarding Article by Wichterle et al, "Prevalent Low-Frequency
Oscillation of Heart Rate: Novel Predictor of Mortality After
Myocardial Infarction." See p
e180.
Letter Regarding Article by Wang et al, "Nesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine." See p e182.
Related Articles:
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Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice
- Daniel T. Eitzman, Randal J. Westrick, Yuechun Shen, Peter F. Bodary, Shufang Gu, Sara L. Manning, Sarah L. Dobies, and David Ginsburg
Circulation 2005 111: 1822-1825.
[Abstract]
[Full Text]
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Prognostic Value of Ambulatory and Home Blood Pressures Compared With Office Blood Pressure in the General Population: Follow-Up Results From the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) Study
- Roberto Sega, Rita Facchetti, Michele Bombelli, Giancarlo Cesana, Giovanni Corrao, Guido Grassi, and Giuseppe Mancia
Circulation 2005 111: 1777-1783.
[Abstract]
[Full Text]
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Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure: Increase in Radical Scavenger Enzyme Activity in Skeletal Muscle
- Axel Linke, Volker Adams, Paul Christian Schulze, Sandra Erbs, Stephan Gielen, Eduard Fiehn, Sven Möbius-Winkler, Andreas Schubert, Gerhard Schuler, and Rainer Hambrecht
Circulation 2005 111: 1763-1770.
[Abstract]
[Full Text]
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Inverted Left Atrial Appendage Ligation Mimicking Thrombus
- Monvadi B. Srichai, Brian Griffin, Michael Banbury, and Ellen Mayer Sabik
Circulation 2005 111: e178-e179.
[Full Text]
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Letter Regarding Article by Wichterle et al, "Prevalent Low-Frequency Oscillation of Heart Rate: Novel Predictor of Mortality After Myocardial Infarction" • Response
- Mari A. Watanabe, Przemyslaw Guzik, Marek Malik, Dan Wichterle, A. John Camm, Jan Simek, Maria Teresa La Rovere, and Peter J. Schwartz
Circulation 2005 111: e180-e181.
[Full Text]
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Letter Regarding Article by Wang et al, "Nesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine" • Response
- Uri Elkayam, David J. Wang, Thomas C. Dowling, Dean Meadows, Tomas Ayala, Joanne Marshall, Stacey Minshall, Nancy Greenberg, Emil Thattassery, Michael L. Fisher, Krishnamurti Rao, and Stephen S. Gottlieb
Circulation 2005 111: e182-e183.
[Full Text]
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