Files in this Data Supplement:

• Figure I - (Power Point) (491 kb) Additional images of sTAB-induced aggresomes. A, Co-localization of vimentin and CryAB immunostaining. B, Co-localization of ubiquitin and CryAB co-immunostaining (scale bar = 25μm).
• Figure II - (Power Point) (1.04 MB) RNAi-mediated knockdown of Beclin 1. A, Representative immunoblots of Beclin 1 protein in NRVMs exposed to control siRNA or Beclin 1 siRNA. B, Quantification of 2 independent Beclin 1 knockdown experiments. C: Representative images of GFP-LC3 fluorescence in NRVMs transfected with control siRNA (left) or Beclin 1 siRNA (right). Scale bar 10 25μm. D, Quantification of GFP-LC3 puncta in NRVMs treated as listed. At least 200 cells were evaluated in each treatment group. E, Cell viability (MTS assay) was not impaired in cells exposed to Beclin 1 RNAi.