Genetic Variation Within Adrenergic Pathways Determines In Vivo Effects of Presynaptic Stimulation in Humans
Circulation Fung et al.
117: 517
Data Supplement
Files in this Data Supplement:
- Supplemental Methods
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(Microsoft Word) (67.5 kb)
- Table I
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(Microsoft Word) (45 kb)
- Table II
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(Microsoft Word) (51.5 kb)
- Figure I
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(Power Point) (54 kb) Dorsal hand vein vasoconstriction as a function of family history of hypertension. Those with a positive family history of hypertension had less constriction with increasing doses of tyramine (P=0.011 by repeated measures ANOVA, with df=8 within subjects, df=16 for dose*family history, and df=2 between subjects). In 16% of subjects, family history was unknown.
- Figure II
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(Power Point) (75 kb) Dorsal hand vein constriction based on tyramine infusion rate, divided by approximate response quartiles. The first quartile experienced only dilation (10 subjects), the second quartile about 25% constriction maximally, the third quartile about 70% maximally, and the fourth quartile (10 subjects) constricted >98%.