Files in this Data Supplement:

• Figure I - (Adobe Acrobat PDF) (411 KB) CGRP immunostaining was reduced in diabetic DRG and DH (A and B). CGRP immunostaining of control and 16-wk-STZ DRG and DH at the T2 level of the sections. The CGRP⁺ proportions in T1-T4 DRG are shown in B (n=4). Representative data are shown in each panel. Scale bar, 100 μm. **P<0.05; vs. relative control.
• Figure II - (Adobe Acrobat PDF) (604 KB) Cardiac-specific overexpression of NGF had protective effect in myocardial ischemia in DM. (A - D) The area at risk (AAR), infarct size (MI), and left ventricular area (LV) were determined after ischemia reperfusion by Evans blue and TTC staining. The area of the myocardium not stained with Evans blue represented AAR, MI appeared pallid, and viable myocardium appeared pink. The increased infarct size observed in WT-DM mice was rescued in NGFTG-DM mice (n=5). (E, F) Apoptotic cardiomyocytes in the ischemic area were detected by TUNEL staining. Boxed areas correspond to the higher power photomicrographs in the insets. Note that the increase in apoptotic myocytes observed in WT-DM mice was reduced in NGFTG-DM mice (n=5). Representative data are shown in each panel. Scale bar, 100 μm (E); 1 mm (A). **P<0.05; ns indicates not significant.
• Supplemental Methods - (Word) (76 KB)