(Circulation. 1997;96:1593-1597.)
© 1997 American Heart Association, Inc.
Articles |
Angiotensin II Increases Tissue Endothelin and Induces Vascular Hypertrophy
Reversal by ETA-Receptor Antagonist
From Cardiology, Cardiovascular Research, and Division of Hypertension (S.S.), University Hospital, Bern, and Cardiology, University Hospital, Zürich, Switzerland.
Correspondence to Thomas F. Lüscher, MD, FACC, FESC, Professor and Head of Cardiology, University Hospital, CH-8091 Zürich, Switzerland. E-mail 100771.1237{at}compuserve.com
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Abstract |
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Background In vitro studies on vascular smooth muscle cells suggest that endothelin has a stimulating effect on cellular proliferation. This study was designed to determine the endogenous effect of endothelin on angiotensin II–induced hypertrophy of small arteries in vivo.
Methods and Results Two weeks of angiotensin II administration (200 ng·kg-1·min-1) increased media thickness, media/lumen ratio, and cross-sectional area of basilar and small mesenteric arteries, confirming the proliferative properties of angiotensin II. The tissue levels of endothelin-1 were elevated in mesenteric arteries after angiotensin II administration. The administration of the selective and specific ETA-receptor antagonist LU135252 (50 mg·kg-1·d-1) in combination with angiotensin II prevented the changes of vascular geometry and partially reduced the increase in blood pressure induced by angiotensin II. Indeed, part of the effect on the vascular structure of the endothelin-receptor antagonist seemed pressure-independent.
Conclusions Our results therefore demonstrate that angiotensin II increases the production of endothelin in the blood vessel wall that, via ETA receptors, mediates changes in vascular structure of the cerebral and mesenteric circulation. Endothelin antagonists may therefore be of value to reduce blood pressure and to prevent vascular structural changes in conditions of increased activity of the renin-angiotensin system.
Key Words: angiotensin • endothelin • receptors • arteries
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Introduction |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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The endothelium regulates vascular tone by releasing vasoactive substances such as NO and ET-1.1 In addition, it is becoming increasingly clear that these endothelium-derived mediators can also affect the migration and proliferation of VSMCs and could therefore be involved in the modification of vascular structure observed in hypertension. As such, ET-1 has proved to be a mitogen2 3 and to induce protein synthesis4 in cultured VSMCs. Furthermore, in DOCA-salt hypertension, in which endothelial expression of ET-1 is enhanced,5 ET-receptor blockade reduces vascular hypertrophy.6
In hypertension, resistance arteries undergo structural changes as an adaptation to increased wall tension.7 These morphological changes may protect the microcirculation against the blood pressure rise, but they could also contribute to the maintenance of hypertension8 and, particularly in the cerebral circulation, to vascular complications. Alterations of small-artery structure may be mediated by eutrophic or hypertrophic vascular remodeling or a combination of the two.8 9 Because chronic administration of Ang II induces hypertrophic remodeling,10 we used this model to study the influence of ET on hypertrophy of small vessels in vivo. Blockade of ETA receptors was used to determine the role of endogenous ET on Ang II–induced proliferation. We hypothesized that a reduced vascular hypertrophy should be observed when an ETA-receptor antagonist is administered with Ang II, because Ang II stimulates the expression and release of ET by endothelial cells.11 12 This would, in turn, confirm the proliferative properties of ET in vivo and its involvement in conditions of increased activity of the renin-angiotensin system.
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Methods |
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Nine-week-old Wistar Kyoto rats were purchased from IFFA CREDO (L'Arbesle, France). Twenty-eight rats (seven per group) were treated for 2 weeks with either Ang II, LU135252, or a combination of Ang II plus LU135252. Seven untreated rats served as controls. Ang II was administered by subcutaneously implanted osmotic pumps (model 2002, Alzet Corp) delivering 200 ng·kg-1·min-1 for 14 days. The ETA-receptor antagonist LU135252 was administered in the food at an average dose of 46±1 mg·kg-1·d-1 in the LU135252 group and 57±4 mg·kg-1·d-1 in the Ang II plus LU135252 group. Before and at the end of treatment, rats were weighed and systolic blood pressure and heart rate were determined by the tail-cuff method (model LE 5000, Letica). All procedures were approved by the Commission for Animal Research of the Canton of Bern, Switzerland.
Animals were anesthetized (thiopental 50 mg/kg IP), and the basilar artery and a segment of the fourth branch of the mesenteric arterial bed (closest segment to the ileum) were isolated under a dissecting microscope in cold (4°C) Krebs solution of the following composition (in mmol/L; control solution): NaCl 118.6, KCl 4.7, CaCl2 2.5, KH2PO4 1.2, MgSO4 1.2, NaHCO3 25.1, edetate calcium disodium 0.026, and glucose 10.1. Arteries were then mounted on and sutured to two small glass cannulas positioned in a vessel chamber (Living Systems Instrumentation) and superfused with control solution (37°C; 95% O2/5% CO2). The perfusion chamber was positioned on the stage of an inverted microscope (Nikon, TSM-F), and the amplified image was transmitted to a monitor and a video dimension analyzer (V91, Living Systems Instrumentation), allowing for measurements of lumen diameter and media thickness. Longitudinal stretch was controlled by adjustment of vessel length to a value slightly superior to the one required to produce a small bending of the vessel at 35 mm Hg of perfusion pressure.
Mesenteric arteries were allowed to equilibrate for 60 minutes and were perfused with control solution containing 1% BSA at constant perfusion pressure (30 mm Hg; Reference 1313 ); resting lumen diameter and media thickness were recorded. Basilar arteries were equilibrated for 60 minutes in a calcium-free control solution to prevent myogenic tone. Perfusion pressure was then increased from 25 to 55 mm Hg in 10 mm Hg steps, and the efferent pressure was adjusted to maintain a constant flow. Vascular structure was determined at each pressure.
LU135252, the active isomer of LU127043, is a selective ETA-receptor antagonist (ratio of affinities for ETA over ETB receptors, 161; Reference 1414 ). Its specificity has been evaluated by radioligand binding assays, and it did not demonstrate any interaction with several receptors, including the rat AT1 receptor (Dr M. Kirchengast, Knoll AG, personal communication). To confirm this, we compared Ang II–mediated contractions in the absence and presence of LU135252 preincubation in aortic rings. Contractions to 10-7 mol/L Ang II, expressed as a percentage of KCl contraction, were as follows: control, 23±3; LU135252 10-6 mol/L, 25±1; and LU135252 10-5 mol/L, 22±2 (n=4; P=NS versus control). Furthermore, contractions to Ang II of mesenteric arteries harvested from rats treated long-term with Ang II (24±5%, n=7) were not different if LU135252 was administered simultaneously (27±7%, n=7).
In separate experiments, 7 to 9 rats were chronically treated as described, and first- to fourth-order branches of the mesenteric arterial tree were dissected free from surrounding tissue for measurement of ET-1 tissue levels. The measurements were performed in a blinded fashion. Tissues were extracted according to a modification of the procedure of Hisaki et al.14A Vessels were weighed and homogenized in a polytron for 60 seconds in 2 mL of ice-cold chloroform:methanol 2:1 containing 1 mmol/L N-ethylmaleimide and 0.1% trifluoroacetic acid. Homogenates were left overnight at 4°C, then 0.8 mL of sterile distilled water was added. The mixture was vortexed and centrifuged at 4000 rpm for 15 minutes, and the supernatant was removed. Aliquots of the extract (1 mL) were diluted with 9 mL of 4% acetic acid and then extracted as described for plasma.15 Eluates were dried in a speed-vac and reconstituted in working assay buffer for radioimmunoassay. Overall recovery for ET-1 added to chloroform/methanol homogenates of vessels and taken through all extraction steps was 65±3%, with interassay and intra-assay coefficients of 5.6% and 10%, respectively (n=6). Plasma ET levels were determined as described.15
Values are mean±SEM. The CSA, growth index, and remodeling index were
calculated as described.8 16 Because CSA does not change
with changes in pressure, a mean of the values obtained at four
different pressures (see above) was calculated for the basilar artery.
The distensibility of the basilar artery is expressed as
micrometer changes per mm Hg of pressure increase and
represents the slope of the pressure–lumen diameter curve.
Statistical evaluation was done by a one-way ANOVA with Bonferroni's
correction for multiple comparisons17 or by one-sample
analysis (growth index, Fig 1
). The contrasts
selected a priori for the ANOVA were Ang II and LU135252 compared
with the control group, and Ang II plus LU135252 compared with Ang II
alone. Pearson's correlation coefficients were calculated by linear
regression. A value of P<.05 was considered
significant.
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) and small mesenteric arteries
(
) in the treatment groups (n=7/group). Growth index is
calculated as ratio of difference between treatment CSA
(CSAt, Table 2
P<.05 vs Ang II alone. |
Results |
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Body weight was reduced in the Ang II group compared with controls, whereas it was normal in all other groups, including the one treated with Ang II in combination with the ETA-receptor antagonist LU135252 (Table 1
). Chronic
administration of Ang II significantly increased systolic blood
pressure (Table 1, Fig 1A
). Although LU135252 had no depressor effect
on its own, it reduced the Ang II–induced increase in blood pressure
(P<.05). Heart rate was not significantly modified by any
chronic treatment, although there was a tendency for Ang II to increase
it.
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In basilar and small mesenteric arteries, Ang II administration
increased media thickness and media/lumen ratio without modifying lumen
diameter (Table 2). The CSA and growth index were also
significantly increased by Ang II (Table 2, Fig 1B). Ang II
administration nearly doubled tissue ET-1 levels (P<.001;
Fig 2), whereas plasma levels of the peptide showed only
a tendency to increase (from 2.6±0.1 to 4.1±0.5 pg/mL;
P=NS).
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The ETA-receptor antagonist LU135252 on its own
had no effect on structure of mesenteric arteries compared with control
vessels. In the basilar artery, LU135252 reduced media thickness and
CSA, leading to a negative growth index (Fig 1B). All structural
vascular changes induced by the administration of Ang II for 2 weeks
were prevented in both vascular beds by the concomitant oral
administration of LU135252 (Table 2, Fig 1B). Compared with chronic Ang
II administration alone (which nearly doubled mesenteric artery ET-1
levels; Fig 2), LU135252 added to the treatment reduced tissue ET-1
levels (P<.05 versus Ang II alone; Fig 2). On its own,
LU135252 had a tendency to reduce tissue ET-1 levels (P=NS).
In contrast, plasma levels of ET-1 were further increased by LU135252
from 2.6±0.1 pg/mL in the placebo group to 6.7±0.4 pg/mL
(P<.05) and from 4.1±0.5 pg/mL in the Ang II group to
8.0±0.7 pg/mL in the Ang II plus LU135252 group
(P<.05).
To confirm that the effect of LU135252 on Ang II–induced
hypertrophy is not due solely to its hypotensive effect,
the relationship between CSA and systolic blood pressure was
constructed (Fig 3A). The Ang II group that was also
treated with LU135252 was significantly dissociated from the linear
regression constructed with the control, Ang II, and LU135252 groups
(P<.005 for basilar and mesenteric arteries; Fig 3A).
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), Ang
II (
), and LU135252 (
)–treated groups, gave the equation
CSA=0.171xSBP-6.33 (r=.99). Calculated CSA for pressure of
150 mm Hg [Ang II+LU135252 group (
) is 19 350
µm2. *Experimental value (15 589±825
µm2, Table 2
There were strong positive correlations between systolic blood
pressure and media/lumen ratio in both basilar (r=.75,
P<.001) and small mesenteric arteries (r=.81,
P<.0001; Fig 3B). The distensibility of the basilar artery,
as determined by the pressure–lumen diameter curves, was similar in
all groups (slope 
2 µm/mm Hg, data not shown), implying that
the modifications of vascular structure could not be accounted for by
an increased stiffness of the vessel wall.
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Discussion |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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In this study, we investigated the contribution of ET to Ang II–induced vascular hypertrophy in vivo. The involvement of endogenous ET in Ang II–induced hypertrophy was determined by the chronic administration of an ETA antagonist LU135252 and by measuring local ET tissue concentrations in the blood vessel wall. Our results demonstrate that Ang II increases vascular ET-1 tissue levels, which in turn mediate a major part of Ang II–stimulated vascular growth and hypertension in vivo.
Chronic administration of Ang II produced thickening of the arterial media as well as an increased media/lumen ratio of basilar and small mesenteric arteries. This alteration of vascular geometry was not accompanied by rearrangement of vascular tissue around a smaller lumen (calculated remodeling index, 8%), a process known as eutrophic remodeling,8 18 but rather by media hypertrophy, as shown by the growth index. Our results therefore confirm those previously reported10 and justify the use of this model to study vascular hypertrophy. Although we did not evaluate whether the increased CSA was secondary to hypertrophy or hyperplasia, a previous study has suggested that the smooth muscle cells of resistance arteries were hypertrophied in this model.8 In addition, this study for the first time demonstrates that Ang II is able to markedly increase vascular ET-1 tissue concentrations, whereas the increase in plasma levels of the peptide was less striking. These results are in line with previous in vitro studies showing that Ang II stimulates ET messenger RNA expression in cultured endothelial cells,11 12 and they extend these findings to in vivo conditions. Furthermore, these results demonstrate that ET is a paracrine local system and that its interaction with the renin-angiotensin system is most striking in the vessel wall rather than in plasma.
The selective ETA-receptor antagonist LU135252 prevented the Ang II–induced hypertrophy of small mesenteric and cerebral arteries. This is, to the best of our knowledge, the first direct evidence of an involvement of ET in Ang II–induced vascular hypertrophy in vivo. This conclusion is strengthened by markedly elevated ET-1 tissue levels in small mesenteric arteries after chronic administration of Ang II and explains the efficacy of an ETA-receptor antagonist to block Ang II–mediated vascular responses. It was of interest to note that LU135252 reduced tissue concentrations of ET-1 but increased plasma levels of the peptide in Ang II–treated animals. The increase in plasma levels of ET-1 during receptor blockade is known and is probably related to displacement of ET-1 from its receptor as well as reduced clearance of the peptide. The fact that LU135252 reduced tissue levels of ET-1 was surprising but may be related to displacement of the peptide from the tissues to the circulation. Alternatively, LU135252 may directly interfere with the production of ET in vascular tissue through its ETA-receptor interaction.
A study in two models of renovascular hypertension failed to demonstrate beneficial effects of an ETA/B-receptor antagonist on vascular structure and blood pressure.19 Because the renin-angiotensin system is involved in this model, the discrepancy with the present study is difficult to reconcile. It is likely that during chronic renovascular hypertension, the renin-angiotensin system is less activated and hence tissue ET levels are no longer increased, or possibly, the time at which treatment is initiated may be of importance. In contrast, one previous study in DOCA-salt hypertensive rats reported a decreased proliferation of the vascular wall with an ETA/B-receptor antagonist.6 However, in the latter model, it is unlikely that Ang II was the endogenous stimulus for increased synthesis of ET, because the activity of the renin-angiotensin system was negligible. Thus, ET may be an important mediator of vascular hypertrophy in hypertension, but the stimulus for its release differs in Ang II–induced and DOCA-salt hypertension.
To our surprise, administration of an ETA-receptor antagonist alone produced relative atrophy (decreased media thickness and CSA, negative growth index) of the basilar artery but not of mesenteric arteries. The cerebral arteries may therefore be under tonic proliferative influence from ET to maintain vascular structure, whereas this is not the case in a peripheral vascular bed.
It is also of interest to note that LU135252 prevented a good part of Ang II–induced hypertension. In isolated small arteries, Ang II–induced vasoconstriction is partly mediated by ET.11 20 Hence, this could explain the antihypertensive effectiveness of LU135252 in this model, which is in contrast to the relative ineffectiveness of ET-receptor antagonists in other models of hypertension, such as the spontaneously hypertensive rat.6 21 Endothelin-receptor antagonists may therefore be more effective in conditions associated with activation of the renin-angiotensin system. In that respect, the literature is conflicting, with one study showing no hypotensive effect of an ET-receptor antagonist in two-kidney, one-clip and one-kidney, one-clip hypertension,19 whereas another study showed a blood pressure reduction in subtotal nephrectomy hypertension.22
To support our conclusion, it was crucial to confirm that LU135252 does not bind to AT1 receptors (see "Methods"). Indeed, radioligand studies and pharmacological experiments with isolated vessels have excluded any interference of LU135252 with AT1 receptors. Furthermore, increased vascular ET-1 levels produced by Ang II suggest an interaction between the two pathways in vivo, independently of LU135252.
Hemodynamic parameters have an impact on
vascular structure,7 8 and this is confirmed by the
relationship between systolic blood pressure and media/lumen
ratio in the present study. Hence, it may be argued that the
antihypertensive effect of LU135252 could be responsible for
normalization of vascular hypertrophy. However, Fig 3A
demonstrates that LU135252 must have direct pressure-independent
effects on hypertrophy. Furthermore, in a study using the
same Ang II regimen, hydralazine lowered blood pressure but did
not modify Ang II–induced vascular
hypertrophy,10 suggesting that part of the
proliferative effect of Ang II is pressure-independent. Hence, we
postulate that stimulation of vascular ET production
represents a pressure-independent mechanism of vascular
hypertrophy.
In conclusion, vascular hypertrophy and the increase in blood pressure induced by Ang II in vivo is mediated at least in part by an increased production of endogenous ET, which then activates ETA receptors to produce the observed changes on the cardiovascular system. Endothelin-receptor antagonists may therefore represent an alternative approach for the treatment of cardiovascular diseases associated with an increased activity of the renin-angiotensin system.
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Selected Abbreviations and Acronyms |
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Acknowledgments |
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LU135252 was kindly provided by Dr M. Kirchengast, Knoll AG, Ludwigshafen, Germany. This work was supported by a grant from the Swiss National Research Foundation (grant 32-32541.91). Pierre Moreau holds a fellowship from the Medical Research Council of Canada, and Livius V. d'Uscio receives a stipend from the Intermedia Foundation, Bern, Switzerland. Matthias Barton was supported by the Deutsche Forschungsgemeinschaft (Ba 1543-1).
Received December 9, 1996; revision received March 25, 1997; accepted March 26, 1997.
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 C.-C. Juan, Y.-W. Shen, Y. Chien, Y.-J. Lin, S.-F. Chang, and L.-T. Ho Insulin infusion induces endothelin-1-dependent hypertension in rats Am J Physiol Endocrinol Metab, November 1, 2004; 287(5): E948 - E954. [Abstract] [Full Text] [PDF]
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J. D. Parker and J. J. Thiessen Increased endothelin-1 production in patients with chronic heart failure Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1141 - H1145. [Abstract] [Full Text] [PDF]
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H.-J. Hong, P. Chan, J.-C. Liu, S.-H. Juan, M.-T. Huang, J.-G. Lin, and T.-H. Cheng Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells Cardiovasc Res, January 1, 2004; 61(1): 159 - 168. [Abstract] [Full Text] [PDF]
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 S. Rich and V. V. McLaughlin Endothelin Receptor Blockers in Cardiovascular Disease Circulation, November 4, 2003; 108(18): 2184 - 2190. [Abstract] [Full Text] [PDF]
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A. Ergul, V. Portik-Dobos, A. D. Giulumian, M. M. Molero, and L. C. Fuchs Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2225 - H2232. [Abstract] [Full Text] [PDF]
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P. Rong, D. J. Campbell, and S. L. Skinner Hypertension in the (mRen-2)27 Rat Is Not Explained by Enhanced Kinetics of Transgenic Ren-2 Renin Hypertension, October 1, 2003; 42(4): 523 - 527. [Abstract] [Full Text] [PDF]
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 L. E. Spieker and T. F. Luscher Endothelin receptor antagonists in heart failure--a refutation of a bold conjecture? Eur J Heart Fail, August 1, 2003; 5(4): 415 - 417. [Full Text] [PDF]
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J. Liu, F. Yang, X.-P. Yang, M. Jankowski, and P. J. Pagano NAD(P)H Oxidase Mediates Angiotensin II-Induced Vascular Macrophage Infiltration and Medial Hypertrophy Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 776 - 782. [Abstract] [Full Text] [PDF]
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 T. M. Seccia, A. S. Belloni, R. Kreutz, M. Paul, G. G. Nussdorfer, A. C. Pessina, and G. P. Rossi Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II J. Am. Coll. Cardiol., February 19, 2003; 41(4): 666 - 673. [Abstract] [Full Text] [PDF]
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G. P. Rossi, M. Cavallin, A. S Belloni, G. Mazzocchi, G. G Nussdorfer, A. C Pessina, and S. Sartore Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension Cardiovasc Res, July 1, 2002; 55(1): 178 - 189. [Abstract] [Full Text] [PDF]
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J. Herrmann, P. J. Best, E. L. Ritman, D. R. Holmes Jr, L. O. Lerman, and A. Lerman Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1555 - 1561. [Abstract] [Full Text] [PDF]
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 L. Ko, A. Maitland, P. W.M. Fedak, A. S. Dumont, M. Badiwala, F. Lovren, C. R. Triggle, T. J. Anderson, V. Rao, and S. Verma Endothelin blockade potentiates endothelial protective effects of ace inhibitors in saphenous veins Ann. Thorac. Surg., April 1, 2002; 73(4): 1185 - 1188. [Abstract] [Full Text] [PDF]
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 A. V Agapitov and W. G Haynes Role of endothelin in cardiovascular disease Journal of Renin-Angiotensin-Aldosterone System, March 1, 2002; 3(1): 1 - 15. [Abstract] [PDF]
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D. Z. Ye and D. H. Wang Function and Regulation of Endothelin-1 and Its Receptors in Salt Sensitive Hypertension Induced by Sensory Nerve Degeneration Hypertension, February 1, 2002; 39(2): 673 - 678. [Abstract] [Full Text] [PDF]
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L. V d'Uscio, M. Barton, S. Shaw, and T. F Luscher Chronic ETA receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice Cardiovasc Res, February 1, 2002; 53(2): 487 - 495. [Abstract] [Full Text] [PDF]
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F. M.A.C. Martens, B. Demeilliers, D. Girardot, C. Daigle, H. H. Dao, D. deBlois, and P. Moreau Vessel-Specific Stimulation of Protein Synthesis by Nitric Oxide Synthase Inhibition: Role of Extracellular Signal-Regulated Kinases 1/2 Hypertension, January 1, 2002; 39(1): 16 - 21. [Abstract] [Full Text] [PDF]
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 F. Fakhouri, S. Placier, R. Ardaillou, J.-C. Dussaule, and C. Chatziantoniou Angiotensin II Activates Collagen Type I Gene in the Renal Cortex and Aorta of Transgenic Mice through Interaction with Endothelin and TGF-{beta} J. Am. Soc. Nephrol., December 1, 2001; 12(12): 2701 - 2710. [Abstract] [Full Text] [PDF]
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 Y. Suzuki, O. Lopez-Franco, D. Gomez-Garre, N. Tejera, C. Gomez-Guerrero, T. Sugaya, R. Bernal, J. Blanco, L. Ortega, and J. Egido Renal Tubulointerstitial Damage Caused by Persistent Proteinuria Is Attenuated in AT1-Deficient Mice : Role of Endothelin-1 Am. J. Pathol., November 1, 2001; 159(5): 1895 - 1904. [Abstract] [Full Text] [PDF]
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A. Prasad, J. P. J. Halcox, M. A. Waclawiw, and A. A. Quyyumi Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1089 - 1095. [Abstract] [Full Text] [PDF]
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G. Arcaro, A. Solini, T. Monauni, A. Cretti, B. Brunato, A. Lechi, R. Fellin, M. Caputo, C. Cocco, E. Bonora, et al. ACE Genotype and Endothelium-Dependent Vasodilation of Conduit Arteries and Forearm Microcirculation in Humans Arterioscler. Thromb. Vasc. Biol., August 1, 2001; 21(8): 1313 - 1319. [Abstract] [Full Text] [PDF]
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J. R. Ballew and G. D. Fink Role of ETA receptors in experimental ANG II-induced hypertension in rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R150 - R154. [Abstract] [Full Text] [PDF]
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F. Ruschitzka, T. Quaschning, G. Noll, A. deGottardi, M. F. Rossier, F. Enseleit, D. Hurlimann, T. F. Luscher, and S. G. Shaw Endothelin 1 Type A Receptor Antagonism Prevents Vascular Dysfunction and Hypertension Induced by 11{beta}-Hydroxysteroid Dehydrogenase Inhibition : Role of Nitric Oxide Circulation, June 26, 2001; 103(25): 3129 - 3135. [Abstract] [Full Text] [PDF]
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T. Quaschning, L. V. d'Uscio, S. Shaw, H. Viswambharan, F. T. Ruschitzka, and T. F. Luscher Chronic vasopeptidase inhibition restores endothelin-converting enzyme activity and normalizes endothelin levels in salt-induced hypertension Nephrol. Dial. Transplant., June 1, 2001; 16(6): 1176 - 1182. [Abstract] [Full Text] [PDF]
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J. B. Park and E. L. Schiffrin ETA Receptor Antagonist Prevents Blood Pressure Elevation and Vascular Remodeling in Aldosterone-Infused Rats Hypertension, June 1, 2001; 37(6): 1444 - 1449. [Abstract] [Full Text] [PDF]
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L. E. Spieker, G. Noll, F. T. Ruschitzka, and T. F. Luscher Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1493 - 1505. [Abstract] [Full Text] [PDF]
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W. Boemke, B. Hocher, N. Schleyer, M. O. Krebs, and G. Kaczmarczyk Hemodynamic, renal, and endocrine responses to acute ETA blockade at different ANG II plasma levels Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1322 - R1331. [Abstract] [Full Text] [PDF]
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 J. R. Ballew, S. W. Watts, and G. D. Fink Effects of Salt Intake and Angiotensin II on Vascular Reactivity to Endothelin-1 J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 345 - 350. [Abstract] [Full Text]
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E. K. Jackson and W. A. Herzer Regional Vascular Selectivity of Angiotensin II J. Pharmacol. Exp. Ther., April 12, 2001; 297(2): 736 - 745. [Abstract] [Full Text]
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T. Quaschning, L. V. d'Uscio, S. Shaw, and T. F. Luscher Vasopeptidase Inhibition Exhibits Endothelial Protection in Salt-Induced Hypertension Hypertension, April 1, 2001; 37(4): 1108 - 1113. [Abstract] [Full Text] [PDF]
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Tong Chuang Feng, Wang Yui Ying, Ren Jang Hua, Y. Y Ji, and M. de Gasparo Effect of valsartan and captopril in rabbit carotid injury. Possible involvement of bradykinin in the antiproliferative action of the renin-angiotensin blockade Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1): 19 - 24. [Abstract] [PDF]
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J.-J. Boffa, Ying Lu, J.-C. Dussaule, and C. Chatziantoniou Improvements of renal lesions and function by angiotensin and endothelin receptor antagonism in nitric oxide-deficient rats Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S211 - S216. [Abstract] [PDF]
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L. G. Bianciotti and A. J. de Bold Modulation of cardiac natriuretic peptide gene expression following endothelin type A receptor blockade in renovascular hypertension Cardiovasc Res, March 1, 2001; 49(4): 808 - 816. [Abstract] [Full Text] [PDF]
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J.-J. Boffa, P.-L. Tharaux, J.-C. Dussaule, and C. Chatziantoniou Regression of Renal Vascular Fibrosis by Endothelin Receptor Antagonism Hypertension, February 1, 2001; 37(2): 490 - 496. [Abstract] [Full Text] [PDF]
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F. Duru, M. Barton, T. F. Luscher, and R. Candinas Endothelin and cardiac arrhythmias: do endothelin antagonists have a therapeutic potential as antiarrhythmic drugs? Cardiovasc Res, February 1, 2001; 49(2): 272 - 280. [Abstract] [Full Text] [PDF]
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R. M. Touyz and E. L. Schiffrin Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells Pharmacol. Rev., December 1, 2000; 52(4): 639 - 672. [Abstract] [Full Text] [PDF]
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T. F. Luscher and M. Barton Endothelins and Endothelin Receptor Antagonists : Therapeutic Considerations for a Novel Class of Cardiovascular Drugs Circulation, November 7, 2000; 102(19): 2434 - 2440. [Abstract] [Full Text] [PDF]
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J.-C. DUSSAULE, P.-L. THARAUX, J.-J. BOFFA, F. FAKHOURI, R. ARDAILLOU, and C. CHATZIANTONIOU Mechanisms Mediating the Renal Profibrotic Actions of Vasoactive Peptides in Transgenic Mice J. Am. Soc. Nephrol., November 1, 2000; 11(90002): S124 - S128. [Abstract] [Full Text] [PDF]
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M. Koyanagi, K. Egashira, S. Kitamoto, W. Ni, H. Shimokawa, M. Takeya, T. Yoshimura, and A. Takeshita Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Induced by Chronic Blockade of Nitric Oxide Synthesis Circulation, October 31, 2000; 102(18): 2243 - 2248. [Abstract] [Full Text] [PDF]
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D. L. Moraes, W. S. Colucci, and M. M. Givertz Secondary Pulmonary Hypertension in Chronic Heart Failure : The Role of the Endothelium in Pathophysiology and Management Circulation, October 3, 2000; 102(14): 1718 - 1723. [Abstract] [Full Text] [PDF]
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R. B. New, A. C. Sampson, M. K. King, J. W. Hendrick, M. J. Clair, J. H. McElmurray III, J. Mandel, R. Mukherjee, Marc de Gasparo, and F. G. Spinale Effects of Combined Angiotensin II and Endothelin Receptor Blockade With Developing Heart Failure : Effects on Left Ventricular Performance Circulation, September 19, 2000; 102(12): 1447 - 1453. [Abstract] [Full Text] [PDF]
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W. S. Waring Early initiation of ACE inhibitor treatment after acute myocardial infarction - a missed therapeutic opportunity? Journal of Renin-Angiotensin-Aldosterone System, September 1, 2000; 1(3): 245 - 251. [PDF]
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T. F Lüscher Endothelial dysfunction: the role and impact of the renin-angiotensin system Heart, September 1, 2000; 84(90001): 20i - 22. [Full Text]
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D. N. Muller, E. M. A. Mervaala, F. Schmidt, J.-K. Park, R. Dechend, E. Genersch, V. Breu, B.-M. Loffler, D. Ganten, W. Schneider, et al. Effect of Bosentan on NF-{kappa}B, Inflammation, and Tissue Factor in Angiotensin II-Induced End-Organ Damage Hypertension, August 1, 2000; 36(2): 282 - 290. [Abstract] [Full Text] [PDF]
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L. G. Bianciotti and A. J. De Bold Effect of selective ETA receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H93 - H101. [Abstract] [Full Text] [PDF]
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S. Dhein, S. Hochreuther, C. a. d. Spring, K. Bollig, C. Hufnagel, and M. Raschack Long-Term Effects of the EndothelinA Receptor Antagonist LU 135252 and the Angiotensin-Converting Enzyme Inhibitor Trandolapril on Diabetic Angiopathy and Nephropathy in a Chronic Type I Diabetes Mellitus Rat Model J. Pharmacol. Exp. Ther., May 1, 2000; 293(2): 351 - 359. [Abstract] [Full Text]
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G. P. Rossi, A. Sacchetto, D. Rizzoni, S. Bova, E. Porteri, G. Mazzocchi, A. S. Belloni, M. Bahcelioglu, G. G. Nussdorfer, and A. C. Pessina Blockade of Angiotensin II Type 1 Receptor and Not of Endothelin Receptor Prevents Hypertension and Cardiovascular Disease in Transgenic (mREN2)27 Rats via Adrenocortical Steroid-Independent Mechanisms Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 949 - 956. [Abstract] [Full Text] [PDF]
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H. Kjekshus, O. A. Smiseth, R. Klinge, E. Oie, M. E. Hystad, and H. Attramadal Regulation of ET: pulmonary release of ET contributes to increased plasma ET levels and vasoconstriction in CHF Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1299 - H1310. [Abstract] [Full Text] [PDF]
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J. Bohlender, S. Gerbaulet, J. Kramer, M. Gross, M. Kirchengast, and R. Dietz Synergistic Effects of AT1 and ETA Receptor Blockade in a Transgenic, Angiotensin II-Dependent, Rat Model Hypertension, April 1, 2000; 35(4): 992 - 997. [Abstract] [Full Text] [PDF]
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M. Lauth, M.-M. Berger, M. Cattaruzza, and M. Hecker Elevated Perfusion Pressure Upregulates Endothelin-1 and Endothelin B Receptor Expression in the Rabbit Carotid Artery Hypertension, February 1, 2000; 35(2): 648 - 654. [Abstract] [Full Text] [PDF]
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M. Lauth, M.-M. Berger, M. Cattaruzza, and M. Hecker Pressure-Induced Upregulation of Preproendothelin-1 and Endothelin B Receptor Expression in Rabbit Jugular Vein In Situ : Implications for Vein Graft Failure? Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 96 - 103. [Abstract] [Full Text] [PDF]
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M. Barton, R. Carmona, H. Morawietz, L. V. d'Uscio, W. Goettsch, H. Hillen, C. C. Haudenschild, J. E. Krieger, K. Munter, T. Lattmann, et al. Obesity Is Associated With Tissue-Specific Activation of Renal Angiotensin-Converting Enzyme In Vivo : Evidence for a Regulatory Role of Endothelin Hypertension, January 1, 2000; 35(1): 329 - 336. [Abstract] [Full Text] [PDF]
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L. Ghiadoni, A. Virdis, A. Magagna, S. Taddei, and A. Salvetti Effect of the Angiotensin II Type 1 Receptor Blocker Candesartan on Endothelial Function in Patients With Essential Hypertension Hypertension, January 1, 2000; 35(1): 501 - 506. [Abstract] [Full Text] [PDF]
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J.-J. Boffa, P.-L. Tharaux, S. Placier, R. Ardaillou, J.-C. Dussaule, and C. Chatziantoniou Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis : Evidence for an Endothelin-Mediated Mechanism Circulation, November 2, 1999; 100(18): 1901 - 1908. [Abstract] [Full Text] [PDF]
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E. L. Schiffrin Role of Endothelin-1 in Hypertension Hypertension, October 1, 1999; 34(4): 876 - 881. [Abstract] [Full Text] [PDF]
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J. Du, T. Peng, K. J. Scheidegger, and P. Delafontaine Angiotensin II Activation of Insulin-Like Growth Factor 1 Receptor Transcription Is Mediated by a Tyrosine Kinase–Dependent Redox-Sensitive Mechanism Arterioscler. Thromb. Vasc. Biol., September 1, 1999; 19(9): 2119 - 2126. [Abstract] [Full Text] [PDF]
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E. Brochu, S. Lacasse-M., C. Moreau, M. Lebel, I. Kingma, J. H. Grose, and R. Lariviere Endothelin ETA receptor blockade prevents the progression of renal failure and hypertension in uraemic rats Nephrol. Dial. Transplant., August 1, 1999; 14(8): 1881 - 1888. [Abstract] [Full Text] [PDF]
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G. P. Rossi, A. Sacchetto, M. Cesari, and A. C Pessina Interactions between endothelin-1 and the renin-angiotensin-aldosterone system Cardiovasc Res, August 1, 1999; 43(2): 300 - 307. [Abstract] [Full Text] [PDF]
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E. BROCHU, S. LACASSE-M, R. LARIVIÈRE, I. KINGMA, J. H. GROSE, and M. LEBEL Differential Effects of Endothelin-1 Antagonists on Erythropoietin-Induced Hypertension in Renal Failure J. Am. Soc. Nephrol., July 1, 1999; 10(7): 1440 - 1446. [Abstract] [Full Text]
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D. P. Wilson, L. Saward, P. Zahradka, and P. Kee Cheung Angiotensin II receptor antagonists prevent neointimal proliferation in a porcine coronary artery organ culture model Cardiovasc Res, June 1, 1999; 42(3): 761 - 772. [Abstract] [Full Text] [PDF]
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K. Munter, H. Ehmke, and M. Kirchengast Maintenance of blood pressure in normotensive dogs by endothelin Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1022 - H1027. [Abstract] [Full Text] [PDF]
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B. Hocher, I. George, J. Rebstock, A. Bauch, A. Schwarz, H.-H. Neumayer, and C. Bauer Endothelin System–Dependent Cardiac Remodeling in Renovascular Hypertension Hypertension, March 1, 1999; 33(3): 816 - 822. [Abstract] [Full Text] [PDF]
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F. C. Luft, E. Mervaala, D. N. Muller, V. Gross, F. Schmidt, J. K. Park, C. Schmitz, A. Lippoldt, V. Breu, R. Dechend, et al. Hypertension-Induced End-Organ Damage : A New Transgenic Approach to an Old Problem Hypertension, January 1, 1999; 33(1): 212 - 218. [Abstract] [Full Text] [PDF]
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P. Moreau Endothelin in hypertension: A role for receptor antagonists? Cardiovasc Res, September 1, 1998; 39(3): 534 - 542. [Abstract] [Full Text] [PDF]
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T. J Rabelink, E. S.G Stroes, K.P. Bouter, and P. Morrison Endothelin blockers and renal protection: a new strategy to prevent end-organ damage in cardiovascular disease? Cardiovasc Res, September 1, 1998; 39(3): 543 - 549. [Full Text] [PDF]
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M. Kirchengast and K. Munter Endothelin and restenosis Cardiovasc Res, September 1, 1998; 39(3): 550 - 555. [Full Text] [PDF]
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L. V. d'Uscio, S. Shaw, M. Barton, and T. F. Luscher Losartan but Not Verapamil Inhibits Angiotensin II–Induced Tissue Endothelin-1 Increase : Role of Blood Pressure and Endothelial Function Hypertension, June 1, 1998; 31(6): 1305 - 1310. [Abstract] [Full Text] [PDF]
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 P. Moreau, H. Takase, L. V. d'Uscio, T. F. Luscher, and G. L. Baumbach Effect of Chronic Nitric Oxide Deficiency on Angiotensin II–Induced Hypertrophy of Rat Basilar Artery • Editorial Comment Stroke, May 1, 1998; 29(5): 1031 - 1036. [Abstract] [Full Text] [PDF]
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M. Barton, L. V. d'Uscio, S. Shaw, P. Meyer, P. Moreau, and T. F. Luscher ETA Receptor Blockade Prevents Increased Tissue Endothelin-1, Vascular Hypertrophy, and Endothelial Dysfunction in Salt-Sensitive Hypertension Hypertension, January 1, 1998; 31(1): 499 - 504. [Abstract] [Full Text] [PDF]
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L. Moser, J. Faulhaber, R. J. Wiesner, and H. Ehmke Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1389 - R1394. [Abstract] [Full Text] [PDF]
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