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*Coronary Artery Disease

(Circulation. 1996;94:2662-2666.)
© 1996 American Heart Association, Inc.


Articles

How Big Are Coronary Atherosclerotic Plaques That Rupture?

Michael C. Fishbein, MD; Robert J. Siegel, MD

the Department of Pathology and Laboratory Medicine (M.C.F.) and Division of Cardiology (R.J.S.), Cedars-Sinai Medical Center/University of California, Los Angeles, School of Medicine.


Key Words: atherosclerosis • plaque • arteries • thrombosis


*    Introduction
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*Introduction
down arrowReferences
 
Plaque erosions (superficial intimal injury) and fissures (tears of variable depth) with overlying microscopic mural thrombosis are common abnormalities of the intimal surface of coronary atherosclerotic plaques. Davies et al1 found small plaque fissures in as many as 17% of patients who died of noncardiac causes. If no overlying obstructive luminal thrombus develops, these small plaque defects will cause no clinical events. Conversely, plaque rupture (disruption of the fibrous cap) that is complicated by occlusive thrombosis is clinically significant and is the underlying lesion in the majority of acute fatal coronary events: acute myocardial infarction and sudden death.2 3 4 5 6

Angiographic studies of coronary arteries before and after nonfatal myocardial infarction have frequently shown that at the site of the complete occlusion, the preexisting, underlying culprit lesion does not usually cause hemodynamically significant stenosis7 8 9 10 11 12 13 14 (Table 1Down). Several published studies have reported that nearly 50% of these lesions are at sites with <50% luminal diameter narrowing. Fewer than 20% of acute complete occlusions occur in lesions with antecedent angiographic diameter narrowing of >75%. Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by <50%. This consensus has been expanded into the notion that nonstenotic, hemodynamically insignificant plaques may rupture, precipitating occlusive thrombosis, myocardial infarction, and/or death. This is a disheartening concept. It suggests that virtually all of the mature men and women of the industrialized world have a constant and unpredictable risk of a catastrophic coronary event.


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Table 1. Severity of Coronary Angiographic Lesions Before Myocardial Infarction

Conversely, histopathological studies from patients with fatal coronary events have consistently shown that at the sites of plaque rupture with superimposed occlusive thrombosis, the underlying lesion is "severe" (Table 2Down, Fig 1Down). Studies in which planimetry was used to measure the plaque determined that the plaque occupied, on average, {approx}90% of the cross-sectional area (68% diameter reduction).2 3 4 5 These studies did not use pressure fixation of the coronary arteries.


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Table 2. Severity of Underlying Stenosis by Atherosclerotic Plaque at Sites of Occlusive Thrombosis* (Cross-sectional Area Narrowing)



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Figure 1. Two typical examples of acute coronary occlusions in fatal ischemic events. Note that with respect to cross-sectional area measurement of stenosis (a, 97%; b, 90%), there is severe underlying atherosclerosis at the site of plaque rupture and thrombosis (asterisk indicates rupture site; T, thrombus) (hematoxylin-eosin; magnification x17).

How does one reconcile two sets of consistent, reliable data that appear to be so different? Usually, when there is such consistent difference in opinion, it means that either everyone is wrong or everyone is partially correct. In this case, comparing angiography and pathology, the divergence arises because the two techniques are not measuring the same thing: the proverbial apples and oranges.

Both angiographic (Table 3Down) and pathological (Table 4Down) examinations are subject to limitations that can result in erroneous results that can lead to either overestimation or underestimation of the degree of luminal narrowing by plaque.15 16 17 18 19 20 21 22 23 24 25 Although these are important, it is our opinion that the most important factors responsible for the long-standing discordance between angiographic and pathological studies do not relate to poor technique or inaccurate interpretation but rather to two biological variables that make it illogical to even attempt to compare these two techniques.


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Table 3. Factors Contributing to Coronary Arteriographic Lesion Underestimation and Overestimation


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Table 4. Factors Contributing to Inaccurate Pathological Quantification of Coronary Atherosclerosis

The two factors most important in understanding angiographic/pathological discordance are (1) the diffuseness of coronary atherosclerosis and (2) vascular remodeling associated with the progression of atherosclerosis.

The diffuse nature of coronary atherosclerosis is well known to pathologists,26 27 28 29 30 angiographers,31 and more recently, coronary ultrasonographers,32 33 yet it seems to be ignored during standard evaluation of angiograms. In individuals with atherosclerotic coronary artery disease, it is virtually impossible to find a segment of the proximal coronary tree that is free of involvement by some degree of atherosclerosis. Thus, the concept of a focal stenosis due to a "plaque" is misleading. The observed plaque is not a discrete lesion but rather just a more severely involved region of a diffuse, widespread process.

The importance of vascular remodeling, elucidated primarily by the work of Glagov and associates34 and others,35 36 37 has only recently begun to be appreciated. This occurrence, now often called the Glagov phenomenon, consists of a progressive, compensatory increase in arterial cross-sectional area as atherosclerotic plaques enlarge. In effect, as the plaque grows, the lumen size remains the same. Thus, lumen size may remain normal despite occupation of {approx}40% of the new arterial cross section by plaques. According to the Glagov concept, it is only when plaques enlarge further that the lumen size becomes compromised.

How then do the diffuseness of coronary atherosclerosis and vascular remodeling affect the angiographic and pathological quantification of coronary atherosclerosis? As shown in Fig 2Down, the degree of stenosis determined angiographically depends on a comparison of lumen diameter at the site of a stenosis with an adjacent site thought to be normal. Because there are no normal sites adjacent to stenotic regions in atherosclerotic coronary arteries, angiography will actually be comparing a severe stenosis with a mild or moderate stenosis and thus will underestimate the volume of disease at the site of stenosis, as shown recently by Mann and Davies.38 Because of compensatory enlargement, a segment of vessel with <=40% involvement of the cross-sectional area by plaque may still have a lumen of normal size and shape. Therefore, by the time angiography detects a lesion, >40% of the arterial cross section may be involved by plaque. Thus, angiography may be fairly accurate in determining lumen size, but it will not detect the "volume" of atherosclerosis present. If the adjacent segment has some mild luminal narrowing, the amount of arterial luminal narrowing compared with a totally normal artery will also be underestimated.



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Figure 2. Top row, Angiographic views. Bottom row, Pathological views. Column A, Normal artery. Column B, Artery with "moderate" atherosclerosis. Because of remodeling, with enlargement of the vessel, the angiographer sees a normal lumen. A pathologist viewing the same artery would see the same lumen, but 50% of the cross-sectional area would be occupied by plaque. Since the pathologist has no way of knowing that this lumen is still of normal size, he or she would conclude that this artery has a 50% cross-sectional area narrowing. Column C, More involved artery. The angiographer sees that the lumen is 50% less in diameter than the adjacent"normal" (B) segment. This would translate into a 75% cross-sectional area narrowing, but the angiographer might conclude that this is mild or moderate disease. The pathologist sees the 2-mm lumen but a larger plaque and measures the stenosis as an 89% narrowing. Column D, Same situation but with even more remodeling present. The angiographer still sees a 50% diameter narrowing, even though the plaque is much larger than in column C, and would still conclude that this is not severe disease. Because of the greater enlargement of the artery, the pathologist now measures the stenosis as a 95% cross-sectional narrowing, even though the lumen size is actually the same as in column C. The pathologist is left with no other explanation than that the angiographer has grossly underestimated the degree of stenosis in this patient's coronary artery.

Conversely, pathological evaluation, as shown in Fig 2Up, will correctly identify the percentage of cross-sectional area occupied by plaque. The pathologist may see a plaque that constitutes, for example, 50% of the cross-sectional area. However, because of the Glagov phenomenon, the artery may have enlarged 50% in cross-sectional area. Thus, the lumen observed may actually still be the same size as the original, normal lumen. Since the pathologist does not know the original cross-sectional area of the artery or the amount of compensatory enlargement of the artery from evaluation of a single cross section of the artery at a site of stenosis, the degree of luminal narrowing of that segment cannot be determined. Because the pathologist determines the degree of stenosis by dividing the lumen area by the total area, the degree of stenosis will be overestimated.

Thus, the angiographer determines the degree of stenosis by comparing lumens, assuming that one is normal, whereas the pathologist determines the degree of stenosis by comparing lumen to total plaque area. The angiographer uses a denominator that is too small, thereby underestimating the degree of stenosis. The pathologist uses a denominator that is too large, thereby overestimating the degree of stenosis. The latter sees the altered donut and the former sees only the hole, and both are attempting to relate their findings to the unseen pristine ring-shaped cake.

Furthermore, in studies reporting progression of insignificant lesions to total thrombotic occlusions, the mean interval between angiography and acute myocardial infarction is 2.5 years, with the interval as long as 12 or 18 years in some studies.7 8 9 10 11 12 13 14 These considerable time intervals could allow for growth of "small" lesions before acute occlusion. Studies such as those by Moise et al14 and Ellis et al39 have shown that the relative risk of developing an acute myocardial infarction in the territory supplied by an artery with a <50% angiographic stenosis is actually quite low. The reported high frequency of acute occlusions in such regions may be at least in part related to the fact that the vast majority of the coronary luminal surface area contains lesions that are relatively mild and only a small percentage of the arterial tree is involved by more severe lesions. Thus, on a statistical basis, even if a region were at low risk for an acute event, if the majority of the arterial tree were composed of such regions, they might appear to be overrepresented in terms of degree of risk of occlusion.

Wherein lies the truth? An accurate determination of the degree of atherosclerosis depends on knowledge of the lumen and plaque area at the site of stenosis and the lumen area at an adjacent normal site. Then, one could determine the degree of luminal narrowing and also the amount of plaque present at any given segment.

Intravascular ultrasound (IVUS) has the potential to provide all of this information (Fig 3Down). IVUS allows quantitative in vivo assessment of the arterial lumen and wall size and shape. It permits delineation of the intima, media, and adventitia and the presence of calcification, lipid pools, and fibrous regions. We used IVUS to study remodeling in coronary arteries with an angiographic diameter stenosis of >70%.40 We compared the stenosis site with a proximal reference site that had <25% diameter narrowing by angiography and <50% cross-sectional area stenosis by IVUS. Compensatory enlargement was defined as being present when the total coronary arterial cross-sectional area at the stenotic site was greater than that at the proximal nonstenotic site. We documented that the majority of stenotic lesions had compensatory enlargement and thus exhibited remodeling. Note, however, that in 26% of arteries there was "inadequate" remodeling in that the total cross-sectional area at the stenotic site was less than that in both the proximal and distal reference sites. Fig 3Down shows IVUS images that provide in vivo verification of the remodeling phenomenon depicted in Fig 2Up. Unfortunately, vascular remodeling is variable and inconsistent. This is not a trivial finding, because it indicates that clinically significant coronary arterial narrowing by atherosclerosis may be a function of not only the amount of atherosclerosis but also the degree of remodeling present.41



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Figure 3. Intravascular ultrasound demonstration of coronary remodeling with atherosclerosis. A, Cross-sectional image of a normal proximal segment. B, Mild concentric lesion with 38% of the area bounded by the media involved by plaque. The lumen is actually larger than the normal segment shown in A. C, Concentric plaque. Because of remodeling, compared with the normal segment shown in A, for example, there is only a 34% reduction in luminal area despite a lesion occupying 69% of the cross-sectional area bounded by the media. D, Larger, eccentric plaque with even greater cross-sectional area involvement by atherosclerosis (89%). Because the entire vessel is larger, the actual decrease in luminal area is only 68%. Note that despite the considerable plaque present, diameter stenosis as would be determined angiographically would be considered mild: 19% in C and 47% in D (all percentages determined by manual planimetry).

What do the concepts discussed here indicate regarding the size of plaques that rupture with superimposed occlusive thrombus? Fig 1Up shows typical examples of two such plaques. According to angiographic studies, we are to assume that in life, before rupture, these plaques were at sites with {approx}50% diameter (75% area) stenoses. By planimetry, the cross-sectional area narrowings are 97% and 90%. These are typical findings at sites of plaque rupture.5 We are aware that the current consensus is that the propensity for plaques to rupture is independent of plaque size; however, in our opinion, the hypothesis that small atherosclerotic plaques are the most likely to rupture, with resulting occlusive thrombosis, is unproven. Furthermore, if this occurs at all, it is a rare event. It is not small but rather large plaques, which may not be producing significant stenosis, that undergo rupture with acute occlusive thrombosis, resulting in myocardial infarction and other ischemic events. Understanding of the angiographic, pathological, and ultrasonic images of atherosclerotic coronary arteries and awareness of their limitations should lead to a better understanding of the biology of coronary atherosclerosis and plaque rupture.


*    Footnotes
 
Reprint requests to Michael C. Fishbein, MD, Department of Pathology and Laboratory Medicine, Room 8732, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048. E-mail fishbein@csmc.edu.


*    References
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*Coronary Artery Disease