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(Circulation. 1995;92:1375.)
© 1995 American Heart Association, Inc.

Articles

Association of Angiotensinogen Gene T235 Variant With Increased Risk of Coronary Heart Disease¹

	Introduction

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Some investigators have reported a homozygous deletion allele of the angiotensin-converting enzyme (ACE) gene (DD) to be associated with an increased risk of myocardial infarction and some variants of the angiotensinogen gene with an increased risk of hypertension. In a case-control study of a white population from New Zealand,¹ the authors examined the associations with coronary heart disease of the ACE gene DD allele and of a missense mutation with methionine-to-threonine amino acid substitution at codon 235 in the angiotensinogen gene (T235). Four hundred twenty-two patients with a mean age of 62 years, of whom 81% were men with documented coronary heart disease (50% with myocardial infarction), and 406 control subjects without known coronary heart disease frequency matched to case patients by age and sex were evaluated. Risk factors for coronary heart disease were assessed by standard questionnaire, physical examination, and blood tests. Genomic DNA from leukocytes was analyzed for various ACE and angiotensinogen alleles. Angiotensinogen T235 homozygotes were at significantly increased risk of coronary heart disease generally (odds ratio, 1.7; 2P=.008) and of myocardial infarction specifically (odds ratio, 1.8; 2P=.009). Adjustment for several risk factors increased the estimate of coronary heart disease risk associated with this allele to 2.6 and the estimate for myocardial infarction risk to 3.4. There was no evidence of a significant increase in the risk of coronary heart disease or myocardial infarction among individuals with the ACE gene DD. The authors concluded that the T235 polymorphism of the angiotensinogen gene is an independent risk factor that carries an approximately twofold increased risk of coronary heart disease.¹

	References

Top Introduction References

 
1. Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Dzau VJ, MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995;345:1600-1603.[Medline] [Order article via Infotrieve]

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