Files in this Data Supplement:

• Figure I - (Microsoft PowerPoint file) (35 KB). Left, Dr. Ludwig Eichna, Professor of Medicine at New York University. My mentor in 1951 when I was a senior medical student. Right, Dr. Andre Cournand, Professor of Medicine at Columbia University. My mentor in 1953-54, when I was a postdoctoral fellow.
• Figure II - (Microsoft PowerPoint file) (1.2 MB). Left, Dr. Andrew Glenn Morrow, Chief of the Clinic of Surgery at the NHLBI, my mentor 1955-60. Right, Dr. Stanley J. Sarnoff, Chief of the Laboratory of Cardiovascular Physiology at the NHLBI, my mentor 1955-57.
• Figure III - (Microsoft PowerPoint file) (211 KB). Anatomic relations of the enlarged left atrium to the main bronchi, allowing transbronchial puncture of the left atrium. (From Morrow AG et al. Circulation 1957;16:1033)
• Figure IV - (Microsoft PowerPoint file) (392 KB). Top, Title (Ross J Jr, Braunwald E, Morrow AG. Circulation 1960;22:927) Bottom, from Brockenbrough EC, Braunwald E. A new technic for left ventricular angiocardiography and transseptal left heart catheterization. Am J Cardiol 1960;6:1062.
• Figure V - (Microsoft PowerPoint file) (311 KB). Comparison of pre-operative and post mitral valve replacement pulmonary vascular resistances in patients with mitral stenosis and mitral regurgitation. (From: Braunwald E et al. N Engl J Med 1965;273:509-14.)
• Figure VI - (Microsoft PowerPoint file) (150 KB). Average course of valvular aortic stenosis in adults. (From: Circulation 1968;37:V61-7.)
• Figure VII - (Microsoft PowerPoint file) (200 KB). Left, Simultaneous left ventricular and brachial artery pressure tracings in a patient with congenital, discrete subvalvular stenosis and mild aortic regurgitation. An increase in the arterial pulse pressure accompanies the rise in peak left ventricular systolic pressure following the premature contraction. Right, Simultaneous left ventricular and brachial artery pressure tracings in a patient with IHSS. Following a premature ventricular contraction, the arterial pulse pressure narrows in association with an increased left ventricular systolic pressure. (From: Circulation 1961;23:189).
• Figure VIII - (Microsoft PowerPoint file) (144 KB). Circulatory response to nitroglycerin in a patient with IHSS. (From: Circulation 1964;29:422-31.)
• Figure IX - (Microsoft PowerPoint file) (275 KB). Family tree of family with IHSS. (From: Braunwald E et al. Circulation 1964;30 Suppl4:3-119.)
• Figure X - (Microsoft PowerPoint file) (322 KB). Top, Title (Harrison DC et al. Circulation 1964;29:84) Bottom, Average number of minutes each subject with IHSS was able to walk while on placebo (left) and while taking propranolol (right). Each circle represents an average of several studies on placebo or propranolol. (From Cohen LS, Braunwald E. Amelioration of angina pectoris in idiopathic hypertrophic subaortic stenosis with beta-adrenergic blockade. Circulation 1967;35:847-51.)
• Figure XI - (Microsoft PowerPoint file) (689 KB). Technique of ventriculomyotomy combined with myectomy. Two parallel incisions are made as shown in A, and the muscle beneath each of them is then split by digital pressure to a depth of 2-3 cm. B. The ridge of endocardium and muscle between the incisions is then resected with an angled rongeur passed from the aortic incision, C, D, E. (From: Morrow AG, Lambrew CT, Braunwald E. Idiopathic subaortic stenosis: II. Operative treatment and the results of pre- and postoperative hemodynamic evaluation. Circulation 1964;29(suppl 4):IV-120-IV-143)
• Figure XII - (Microsoft PowerPoint file) (320 KB). Relation between initial velocity of isotonic shortening and afterload of excised human papillary muscle studied in a myograph. Frequency of contractions = 12/minute. Muscle cross-sectional area = 3.2mm2. Preload = 1.4 g with a muscle length of 15 mm. The insert in the upper right shows several oscilloscopic recordings from which the experimental points were calculated, and the afterload for each of these contractions is indicated. (From : Sonnenblick EH, Braunwald E, Morrow AG. J Clin Invest 1965;44:966-77.)
• Figure XIII - (Microsoft PowerPoint file) (96 KB). Force-velocity relations of the right ventricular papillary muscles excised from normal cats and cats with heart failure. Average values with + SEM are given for each point. Velocity has been corrected to muscle lengths per second (Lo/sec). (Modified from: Spann JF Jr, Buccino RA, Sonnenblick EH, Braunwald E. Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res 1967;21:341-54.)
• Figure XIV - (Microsoft PowerPoint file) (153 KB). Top, Title (Folse R, Braunwald E. Circulation 1962;25:674) Bottom, Left ventricular time-concentration curve of I131 in the left ventricle a patient with aortic stenosis following aortic valvulotomy. (From Braunwald E, Morrow AG, Folse R. The use of radioisotopes in clinical studies of the central circulation. Prog Cardivasc Dis 1962;4:543-64.)
• Figure XV - (Microsoft PowerPoint file) (143 KB). Urinary excretion of norepinephrine (NE) in 24 hrs in normal volunteers and cardiac patients in various classes of heart failure according to the New York Heart Association. (From: Chidsey CA, Braunwald E, Morrow AG. Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure. Am J Med 1965;39:442-51.)
• Figure XVI - (Microsoft PowerPoint file) (94 KB). Cumulative mortality from all causes in the study groups in the SAVE trial. (From: Pfeffer MA, Braunwald E, Moye LA et al. Effects of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement trial. N Engl J Med 1992;327:669-77.)
• Figure XVII - (Microsoft PowerPoint file) (2.7 MB). Top, Tissue plasminogen activator (tPA) improves reperfusion (left) and coronary patency (right) when compared to streptokinase (SK) in patients with acute myocardial infarction receiving fibrinolytic therapy in MI. The TIMI 1 trial enrolled 290 patients with acute MI and randomized them to tPA or SK. (from TIMI Study Group NEJM 1985;312:932-6) Bottom, Regardless of treatment arm, a patent infarct-related artery at 90 minutes was associated with improved long-term survival. (From Dalen AJC 1988;62:179-85)
• Figure XVIII - (Microsoft PowerPoint file) (78 KB). The TACTICS-TIMI 18 trial randomized 2,220 patients with UA or NSTEMI to an early invasive strategy (routine cardiac catheterization <48h) or conservative strategy. An early invasive strategy significantly reduced the risk of the primary endpoint of death, MI or rehospitalization with ACS. (From: Cannon CP Weintraub WS, Demopoulos LA et al. N Engl J Med. 2001;344:1879-87)
• Figure XIX - (Microsoft PowerPoint file) (183 KB). The PROVE IT-TIMI 22 trial (55) randomized 4162 subjects following an acute coronary event to intensive statin therapy (80 mg at orvastatin per day against usual statin therapy (pravastatin 40 mg daily) (From: Ray KK, Cannon CP, McCabe CH et al. Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes. J Am Coll Cardiol 2005;46:1405-10.)
• Figure XX - (Microsoft PowerPoint file) (118 KB). TRITON-TIMI 38 randomized 13,608 patients with ACS undergoing percutaneous coronary intervention to prasugrel or clopidogrel. Prasugrel significantly reduced the risk of death, MI or stroke. Prasugrel also significantly increased the risk of TIMI major bleeding. (From: Wiviott SD, Braunwald E, McCabe CH, et al. N Engl. J.Med 2007;357:2001-15)