This Article Extract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Elkayam, U. Articles by Mehra, A. Search for Related Content PubMed Articles by Elkayam, U. Articles by Mehra, A. Related Collections Cardio-renal physiology/pathophysiology

(Circulation. 2008;118:e676.)
© 2008 American Heart Association, Inc.

Correspondence

Response to Letter Regarding Article, "Renal Vasodilatory Action of Dopamine in Patients With Heart Failure: Magnitude of Effect and Site of Action"

Uri Elkayam, MD; Tien M.H. Ng, PharmD; Parta Hatamizadeh, MD; Munir Janmohamed, MD; Anilkumar Mehra, MD

Division of Cardiology, University of Southern California, Keck School of Medicine, Los Angeles, Calif

Drs Lema and Canessa point out the important intersubject variability of plasma levels of dopamine, which has been shown in normal volunteers. These differences may also be related to the interpatient variability in dopamine dose producing the largest effect on renal blood flow. In our study,¹ 5 patients demonstrated a maximal increase in renal blood flow at a dopamine dose 3 µg · kg^–1 · min^–1, whereas 3 patients demonstrated a maximal increase in renal blood flow at a dose of 5 µg · kg^–1 · min^–1, and 5 patients demonstrated a maximal increase in renal blood flow at dose of 10 µg · kg^–1 · min^–1. The majority of the patients, therefore, exhibited the greatest response to dopamine at doses greater than the traditional "renal dose."

	Acknowledgments

 
Disclosures

None.

	Reference

Top Reference

 
1. Elkayam U, Ng TM, Hatamizadeh P, Janmohamed M, Mehra A. Renal vasodilatory action of dopamine in patients with heart failure: magnitude of effect and site of action. Circulation. 2008; 117: 200–205.[Abstract/Free Full Text]

This Article Extract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Elkayam, U. Articles by Mehra, A. Search for Related Content PubMed Articles by Elkayam, U. Articles by Mehra, A. Related Collections Cardio-renal physiology/pathophysiology