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Circulation. 2008;117:e25-e146
Published online before print December 17, 2007, doi: 10.1161/CIRCULATIONAHA.107.187998
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(Circulation. 2008;117:e25-e146.)
© 2008 American Heart Association, Inc.


AHA Statistical Update

Heart Disease and Stroke Statistics—2008 Update

A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

Writing Group: Wayne Rosamond, PhD, FAHA; Katherine Flegal, PhD*; Karen Furie, MD; Alan Go, MD; Kurt Greenlund, PhD*; Nancy Haase; Susan M. Hailpern, DrPH, MS; Michael Ho, MD, PhD; Virginia Howard, MSPH, FAHA; Bret Kissela, MD; Steven Kittner, MD; Donald Lloyd-Jones, MD, FAHA; Mary McDermott, MD; James Meigs, MD; Claudia Moy, PhD; Graham Nichol, MD; Christopher O’Donnell, MD, MPH, FAHA; Veronique Roger, MD; Paul Sorlie, PhD; Julia Steinberger, MD, MSC; Thomas Thom; Matt Wilson, MD; Yuling Hong, MD, PhD, FAHA, for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee


*    Table of Contents
up arrowTop
*Table of Contents
down arrowDisease Prevalence
down arrowRisk Factor Prevalence
down arrowIncidence and Recurrent Attacks
down arrowMortality
down arrowPopulation Estimates
down arrowHospital Discharges and...
down arrowInternational Classification of...
down arrowAge Adjustment
down arrowData Years for National...
down arrowCardiovascular Disease
down arrowRace
down arrowContacts
down arrowReferences
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowOut-of-Hospital Cardiac Arrest
down arrowAwareness of Warning Signs...
down arrowRisk Factors
down arrowImpact of Healthy Lifestyle...
down arrowHospital Discharges, Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowReferences 
down arrowCoronary Heart Disease
down arrowAcute Coronary Syndrome
down arrowAngina Pectoris
down arrowReferences  
down arrowPrevalence
down arrowTransient Ischemic Attack
down arrowIncidence
down arrowMortality
down arrowStroke Risk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowStroke in Children
down arrowReferences   
down arrowMortality
down arrowRisk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowAwareness, Treatment, and...
down arrowCost
down arrowPrehypertension
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowHospitalizations
down arrowReferences    
down arrowIncidence
down arrowRisk Factors
down arrowLeft Ventricular Function
down arrowMortality
down arrowHospital Discharges
down arrowCost
down arrowReferences    
down arrowArrhythmias (Disorders of Heart...
down arrowArteries, Diseases of
down arrowBacterial Endocarditis
down arrowCardiomyopathy
down arrowRheumatic Fever/Rheumatic Heart...
down arrowValvular Heart Disease
down arrowVenous Thromboembolism
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowSecondhand Smoke
down arrowAftermath
down arrowSmokeless Tobacco
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowAdherence
down arrowTriglycerides
down arrowReferences    
down arrowPrevalence
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowMortality
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowAwareness
down arrowAftermath
down arrowRisk Factors
down arrowCost
down arrowReferences    
down arrowAge, Sex, Race, and...
down arrowChronic Kidney Disease
down arrowESRD/CKD and CVD
down arrowReferences    
down arrowChildren/Adolescents
down arrowRisk
down arrowReferences    
down arrowFat/Meat
down arrowFiber
down arrowFruits/Vegetables
down arrowCosts
down arrowReferences    
down arrowACS Quality-of-Care Measures
down arrowReferences    
down arrowCoronary Artery Bypass Surgery
down arrowHeart Transplantations
down arrowReferences    
down arrowReferences    
down arrowReferences    
down arrowNote
 

Summary...e26
1. About These Statistics...e28
2. Cardiovascular Diseases...e31
3. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pectoris...e50
4. Stroke...e61
5. High Blood Pressure...e76
6. Congenital Cardiovascular Defects...e82
7. Heart Failure...e86
8. Other Cardiovascular Diseases...e90
   — Arrhythmias (Disorders of Heart Rhythm)...e90
   — Arteries, Diseases of (Including Peripheral Arterial Disease)...e91
   — Bacterial Endocarditis...e92
   — Cardiomyopathy...e93
   — Rheumatic Fever/Rheumatic Heart Disease...e93
   — Valvular Heart Disease...e93
   — Venous Thromboembolism...e93

9. Risk Factor: Smoking/Tobacco Use...e97
10. Risk Factor: High Blood Cholesterol and Other Lipids...e102
11. Risk Factor: Physical Inactivity...e106
12. Risk Factor: Overweight and Obesity...e109
13. Risk Factor: Diabetes Mellitus...e113
14. End-Stage Renal Disease and Chronic Kidney Disease...e120
15. Metabolic Syndrome...e123
16. Nutrition...e125
17. Quality of Care...e128
18. Medical Procedures...e133
19. Economic Cost of Cardiovascular Diseases...e137
20. At-a-Glance Summary Tables...e139
   — Males and Cardiovascular Diseases...e139
   — Females and Cardiovascular Diseases...e140
   — Ethnic Groups and Cardiovascular Diseases...e141
   — Children, Youth, and Cardiovascular Diseases...e142

21. Glossary ...e143
Disclosures...e146
Appendix I: List of Statistical Fact Sheets. URL: http://www.americanheart.org/presenter.jhtml?identifier=2007


*    Acknowledgments
 
We thank Drs Robert Adams, Gary Friday, Philip Gorelick, and Sylvia Wasserthiel-Smoller, members of Stroke Statistics Subcommittee; Drs Joe Broderick, Brian Eigel, Kimberlee Gauveau, Jane Khoury, Jerry Potts, Jane Newburger, and Kathryn Taubert; and Sean Coady and Michael Wolz for their valuable comments and contributions. We acknowledge Tim Anderson and Tom Schneider for their editorial contributions and Karen Modesitt for her administrative assistance.


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Writing Group Disclosures


 

Summary

Each year the American Heart Association, in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together the most up-to-date statistics on heart disease, stroke, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update. The Statistical Update is a valuable resource for researchers, clinicians, healthcare policy makers, media, the lay public, and many others who seek the best national data available on disease and risk factor prevalence, disease incidence, and mortality rates in a single document. This year’s edition includes several areas not covered in previous editions. Below are a few highlights from this year’s Update in the areas of cardiovascular disease (CVD) mortality, control of risk factors, kidney disease, and medical care.

Death rates from CVD have declined, yet the burden of disease remains high.

Control of risk factors remains an issue for many Americans.

The 2008 Update expands data coverage of CVD-related kidney disease.

Improvements in medical care are being made.

The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current data available in the Statistics Update. The 2005 preliminary mortality data have been released, and although not included in this year’s Update, more information can be found at the National Center for Health Statistics Web site, http://www.cdc.gov/nchs/products/pubs/pubd/hestats/prelimdeaths05/prelimdeaths05.htm.


 

1. About These Statistics

The American Heart Association (AHA) works with the Centers for Disease Control and Prevention’s National Center for Health Statistics (CDC/NCHS); the National Heart, Lung, and Blood Institute (NHLBI); the National Institute of Neurological Disorders and Stroke (NINDS); and other government agencies to derive the annual statistics in this Update. This chapter describes the most important sources and the types of data we use from them. For more details and an alphabetical list of abbreviations, see Chapter 21 of this document, the Glossary and Abbreviation Guide.

The surveys used are:

Behavioral Risk Factor Surveillance Survey (BRFSS)—ongoing telephone health survey system
Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS)—stroke incidence rates and outcome within a biracial population
Medical Expenditure Panel Survey (MEPS)—data on specific health services that Americans use, how frequently they use them, the cost of these services, and how they are paid for
National Health and Nutrition Examination Survey (NHANES)—disease and risk factor prevalence and nutrition statistics
National Health Interview Survey (NHIS)—disease and risk factor prevalence
National Hospital Discharge Survey (NHDS)—hospital inpatient discharges (discharged alive, dead, or status unknown)
National Ambulatory Medical Care Survey (NAMCS)—physician office visits
National Hospital Ambulatory Medical Care Survey (NHAMCS)—hospital outpatient and emergency department visits
National Inpatient Sample (NIS) of the Agency for Health Research and Quality—hospital inpatient discharges and charges
National Institute of Neurological Disorders and Stroke (NINDS)—brain and nervous system disorders
National Nursing Home Survey (NNHS)—nursing home visits
National Vital Statistics—national and state mortality data
World Health Organization (WHO)—country mortality
Youth Risk Behavior Surveillance (YRBS)—trends for 6 categories of priority health-risk behaviors in youth and young adults


*    Disease Prevalence
up arrowTop
up arrowTable of Contents
*Disease Prevalence
down arrowRisk Factor Prevalence
down arrowIncidence and Recurrent Attacks
down arrowMortality
down arrowPopulation Estimates
down arrowHospital Discharges and...
down arrowInternational Classification of...
down arrowAge Adjustment
down arrowData Years for National...
down arrowCardiovascular Disease
down arrowRace
down arrowContacts
down arrowReferences
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowOut-of-Hospital Cardiac Arrest
down arrowAwareness of Warning Signs...
down arrowRisk Factors
down arrowImpact of Healthy Lifestyle...
down arrowHospital Discharges, Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowReferences 
down arrowCoronary Heart Disease
down arrowAcute Coronary Syndrome
down arrowAngina Pectoris
down arrowReferences  
down arrowPrevalence
down arrowTransient Ischemic Attack
down arrowIncidence
down arrowMortality
down arrowStroke Risk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowStroke in Children
down arrowReferences   
down arrowMortality
down arrowRisk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowAwareness, Treatment, and...
down arrowCost
down arrowPrehypertension
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowHospitalizations
down arrowReferences    
down arrowIncidence
down arrowRisk Factors
down arrowLeft Ventricular Function
down arrowMortality
down arrowHospital Discharges
down arrowCost
down arrowReferences    
down arrowArrhythmias (Disorders of Heart...
down arrowArteries, Diseases of
down arrowBacterial Endocarditis
down arrowCardiomyopathy
down arrowRheumatic Fever/Rheumatic Heart...
down arrowValvular Heart Disease
down arrowVenous Thromboembolism
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowSecondhand Smoke
down arrowAftermath
down arrowSmokeless Tobacco
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowAdherence
down arrowTriglycerides
down arrowReferences    
down arrowPrevalence
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowMortality
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowAwareness
down arrowAftermath
down arrowRisk Factors
down arrowCost
down arrowReferences    
down arrowAge, Sex, Race, and...
down arrowChronic Kidney Disease
down arrowESRD/CKD and CVD
down arrowReferences    
down arrowChildren/Adolescents
down arrowRisk
down arrowReferences    
down arrowFat/Meat
down arrowFiber
down arrowFruits/Vegetables
down arrowCosts
down arrowReferences    
down arrowACS Quality-of-Care Measures
down arrowReferences    
down arrowCoronary Artery Bypass Surgery
down arrowHeart Transplantations
down arrowReferences    
down arrowReferences    
down arrowReferences    
down arrowNote
 
Prevalence is an estimate of how many people have a disease at a given point or period in time. The NCHS conducts health examination and health interview surveys that provide estimates of the prevalence of diseases and risk factors. In this Update, the health interview part of the NHANES is used for the prevalence of cardiovascular diseases (CVD). NHANES is used more than the NHIS because in NHANES, angina pectoris (AP) is based on the Rose Questionnaire; estimates are made regularly for heart failure (HF); hypertension is based on blood pressure (BP) measurements and interviews; and an estimate can be made of total CVD to include myocardial infarction (MI), AP, HF, stroke, and hypertension.

A major emphasis of this Update is to present the latest estimates of the number of persons in the United States who have specific conditions in order to provide a more realistic estimate of burden. Most estimates based on NHANES prevalence rates use data collected from 1999 to 2004 (in most cases, these are the latest published figures). These are applied to census population estimates for 2005. Differences in population estimates based on extrapolations of rates beyond the data collection period by using more recent census population estimates cannot be used to evaluate possible trends in prevalence. Trends can only be evaluated by comparing prevalence rates estimated from surveys conducted in different years.


*    Risk Factor Prevalence
up arrowTop
up arrowTable of Contents
up arrowDisease Prevalence
*Risk Factor Prevalence
down arrowIncidence and Recurrent Attacks
down arrowMortality
down arrowPopulation Estimates
down arrowHospital Discharges and...
down arrowInternational Classification of...
down arrowAge Adjustment
down arrowData Years for National...
down arrowCardiovascular Disease
down arrowRace
down arrowContacts
down arrowReferences
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowOut-of-Hospital Cardiac Arrest
down arrowAwareness of Warning Signs...
down arrowRisk Factors
down arrowImpact of Healthy Lifestyle...
down arrowHospital Discharges, Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowReferences 
down arrowCoronary Heart Disease
down arrowAcute Coronary Syndrome
down arrowAngina Pectoris
down arrowReferences  
down arrowPrevalence
down arrowTransient Ischemic Attack
down arrowIncidence
down arrowMortality
down arrowStroke Risk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowStroke in Children
down arrowReferences   
down arrowMortality
down arrowRisk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowAwareness, Treatment, and...
down arrowCost
down arrowPrehypertension
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowHospitalizations
down arrowReferences    
down arrowIncidence
down arrowRisk Factors
down arrowLeft Ventricular Function
down arrowMortality
down arrowHospital Discharges
down arrowCost
down arrowReferences    
down arrowArrhythmias (Disorders of Heart...
down arrowArteries, Diseases of
down arrowBacterial Endocarditis
down arrowCardiomyopathy
down arrowRheumatic Fever/Rheumatic Heart...
down arrowValvular Heart Disease
down arrowVenous Thromboembolism
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowSecondhand Smoke
down arrowAftermath
down arrowSmokeless Tobacco
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowAdherence
down arrowTriglycerides
down arrowReferences    
down arrowPrevalence
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowMortality
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowAwareness
down arrowAftermath
down arrowRisk Factors
down arrowCost
down arrowReferences    
down arrowAge, Sex, Race, and...
down arrowChronic Kidney Disease
down arrowESRD/CKD and CVD
down arrowReferences    
down arrowChildren/Adolescents
down arrowRisk
down arrowReferences    
down arrowFat/Meat
down arrowFiber
down arrowFruits/Vegetables
down arrowCosts
down arrowReferences    
down arrowACS Quality-of-Care Measures
down arrowReferences    
down arrowCoronary Artery Bypass Surgery
down arrowHeart Transplantations
down arrowReferences    
down arrowReferences    
down arrowReferences    
down arrowNote
 
The NHANES 1999–2004 data are used in this Update to present estimates of the percentage of persons with high lipid values, diabetes, overweight, and obesity. The NHIS is used for the prevalence of cigarette smoking and physical inactivity. Data for students in grades 9 through 12 are obtained from the Youth Risk Factor Surveillance System.


*    Incidence and Recurrent Attacks
up arrowTop
up arrowTable of Contents
up arrowDisease Prevalence
up arrowRisk Factor Prevalence
*Incidence and Recurrent Attacks
down arrowMortality
down arrowPopulation Estimates
down arrowHospital Discharges and...
down arrowInternational Classification of...
down arrowAge Adjustment
down arrowData Years for National...
down arrowCardiovascular Disease
down arrowRace
down arrowContacts
down arrowReferences
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowOut-of-Hospital Cardiac Arrest
down arrowAwareness of Warning Signs...
down arrowRisk Factors
down arrowImpact of Healthy Lifestyle...
down arrowHospital Discharges, Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowReferences 
down arrowCoronary Heart Disease
down arrowAcute Coronary Syndrome
down arrowAngina Pectoris
down arrowReferences  
down arrowPrevalence
down arrowTransient Ischemic Attack
down arrowIncidence
down arrowMortality
down arrowStroke Risk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowStroke in Children
down arrowReferences   
down arrowMortality
down arrowRisk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowAwareness, Treatment, and...
down arrowCost
down arrowPrehypertension
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowHospitalizations
down arrowReferences    
down arrowIncidence
down arrowRisk Factors
down arrowLeft Ventricular Function
down arrowMortality
down arrowHospital Discharges
down arrowCost
down arrowReferences    
down arrowArrhythmias (Disorders of Heart...
down arrowArteries, Diseases of
down arrowBacterial Endocarditis
down arrowCardiomyopathy
down arrowRheumatic Fever/Rheumatic Heart...
down arrowValvular Heart Disease
down arrowVenous Thromboembolism
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowSecondhand Smoke
down arrowAftermath
down arrowSmokeless Tobacco
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowAdherence
down arrowTriglycerides
down arrowReferences    
down arrowPrevalence
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowMortality
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowIncidence
down arrowMortality
down arrowAwareness
down arrowAftermath
down arrowRisk Factors
down arrowCost
down arrowReferences    
down arrowAge, Sex, Race, and...
down arrowChronic Kidney Disease
down arrowESRD/CKD and CVD
down arrowReferences    
down arrowChildren/Adolescents
down arrowRisk
down arrowReferences    
down arrowFat/Meat
down arrowFiber
down arrowFruits/Vegetables
down arrowCosts
down arrowReferences    
down arrowACS Quality-of-Care Measures
down arrowReferences    
down arrowCoronary Artery Bypass Surgery
down arrowHeart Transplantations
down arrowReferences    
down arrowReferences    
down arrowReferences    
down arrowNote
 
An incidence rate refers to the number of new cases of a disease that develop in a population per unit of time. The unit of time is not necessarily 1 year, although we often discuss incidence in terms of 1 year. For some statistics, new and recurrent attacks or cases are combined. Our national incidence estimates for the various types of CVD are extrapolations to the US population from the Framingham Heart Study (FHS), the Atherosclerosis Risk in Communities (ARIC) study, the Cardiovascular Health Study (CHS) conducted by the NHLBI, and the Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS) funded by the NINDS. The rates change only when new data are available; they are not computed annually. Do not compare the incidence or the rates with those in past editions of the Heart and Stroke Statistical Update (renamed the Heart Disease and Stroke Statistics Update). Doing so can lead to serious misinterpretation of time trends.


*    Mortality
up arrowTop
up arrowTable of Contents
up arrowDisease Prevalence
up arrowRisk Factor Prevalence
up arrowIncidence and Recurrent Attacks
*Mortality
down arrowPopulation Estimates
down arrowHospital Discharges and...
down arrowInternational Classification of...
down arrowAge Adjustment
down arrowData Years for National...
down arrowCardiovascular Disease
down arrowRace
down arrowContacts
down arrowReferences
down arrowPrevalence
down arrowIncidence
*Mortality
down arrowOut-of-Hospital Cardiac Arrest
down arrowAwareness of Warning Signs...
down arrowRisk Factors
down arrowImpact of Healthy Lifestyle...
down arrowHospital Discharges, Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowReferences 
down arrowCoronary Heart Disease
down arrowAcute Coronary Syndrome
down arrowAngina Pectoris
down arrowReferences  
down arrowPrevalence
down arrowTransient Ischemic Attack
down arrowIncidence
*Mortality
down arrowStroke Risk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowCost
down arrowOperations and Procedures
down arrowStroke in Children
down arrowReferences   
*Mortality
down arrowRisk Factors
down arrowAftermath
down arrowHospital Discharges/Ambulatory...
down arrowAwareness, Treatment, and...
down arrowCost
down arrowPrehypertension
down arrowReferences    
down arrowPrevalence
down arrowIncidence
*Mortality
down arrowHospitalizations
down arrowReferences    
down arrowIncidence
down arrowRisk Factors
down arrowLeft Ventricular Function
*Mortality
down arrowHospital Discharges
down arrowCost
down arrowReferences    
down arrowArrhythmias (Disorders of Heart...
down arrowArteries, Diseases of
down arrowBacterial Endocarditis
down arrowCardiomyopathy
down arrowRheumatic Fever/Rheumatic Heart...
down arrowValvular Heart Disease
down arrowVenous Thromboembolism
down arrowReferences    
down arrowPrevalence
down arrowIncidence
*Mortality
down arrowSecondhand Smoke
down arrowAftermath
down arrowSmokeless Tobacco
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowAdherence
down arrowTriglycerides
down arrowReferences    
down arrowPrevalence
down arrowCost
down arrowReferences    
down arrowPrevalence
*Mortality
down arrowCost
down arrowReferences    
down arrowPrevalence
down arrowIncidence
*Mortality
down arrowAwareness
down arrowAftermath
down arrowRisk Factors
down arrowCost
down arrowReferences    
down arrowAge, Sex, Race, and...
down arrowChronic Kidney Disease
down arrowESRD/CKD and CVD
down arrowReferences    
down arrowChildren/Adolescents
down arrowRisk
down arrowReferences    
down arrowFat/Meat
down arrowFiber
down arrowFruits/Vegetables
down arrowCosts
down arrowReferences    
down arrowACS Quality-of-Care Measures
down arrowReferences    
down arrowCoronary Artery Bypass Surgery
down arrowHeart Transplantations
down arrowReferences    
down arrowReferences    
down arrowReferences    
down arrowNote
 
Mortality data are grouped according to the underlying cause of death. "Total-mention" mortality is the number of death certificates in 2004 that mention the given disease classification either as the underlying cause or as a contributing cause. These were final 2004 data unless otherwise indicated. For many deaths classified as attributable to CVD, selection of the most likely single underlying cause can be difficult when several major comorbidities are present, as is often the case in the elderly population. It is, therefore, useful to know the extent of mortality from a given cause, regardless of whether it is the underlying cause or a contributing cause—ie, its "total mentions." In all comparisons of deaths and death rates between 1994 and 2004, 1994 data were modified using appropriate comparability ratios.

The first text section for each disease listed in this Update mentions mortality information. This includes the number of deaths for which the disease is the underlying cause; this is referred to as "mortality." That number is followed by "total-mention mortality." All other numbers or rates of deaths in the Update refer to the given disease as the underlying cause. The one exception, heart failure, is explained in that section.

National and state mortality data presented according to the underlying cause of death are computed from the Data Warehouse mortality tables of