Circulation. 2007;116:1170-1175
Published online before print August 13, 2007, doi: 10.1161/CIRCULATIONAHA.106.645614
Published online before print August 13, 2007, doi: 10.1161/CIRCULATIONAHA.106.645614
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(Circulation. 2007;116:1170-1175.)
© 2007 American Heart Association, Inc.
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CLINICAL PERSPECTIVE
The potential impact of this work relates to preclinical detection and prevention of obesity- and diabetes mellitus–related cardiomyopathy. Combined cardiac magnetic resonance imaging and spectroscopy provides a noninvasive diagnostic tool that allows precise measurement of myocardial lipid content. Currently, the technology is available in a handful of centers, but it could become more widely applied, because examination time already is <30 minutes. The present report establishes normative values of myocardial lipid content and implicates lipid overstorage in the heart as an important component of impaired glucose tolerance even before the onset of frank diabetes or systolic dysfunction. Assessment of myocardial lipid content could lead to an enhanced understanding of the relationship between abnormalities in glucose handling and myocardial dysfunction, particularly in obese individuals, and potentially provide a new cardiac-specific measure for evaluating responses to interventions that improve global glucose tolerance (eg, weight loss, exercise, and insulin sensitizers).This article has been cited by other articles:
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