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Circulation. 2007;116:1170-1175
Published online before print August 13, 2007, doi: 10.1161/CIRCULATIONAHA.106.645614
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(Circulation. 2007;116:1170-1175.)
© 2007 American Heart Association, Inc.


Imaging

CLINICAL PERSPECTIVE

The potential impact of this work relates to preclinical detection and prevention of obesity- and diabetes mellitus–related cardiomyopathy. Combined cardiac magnetic resonance imaging and spectroscopy provides a noninvasive diagnostic tool that allows precise measurement of myocardial lipid content. Currently, the technology is available in a handful of centers, but it could become more widely applied, because examination time already is <30 minutes. The present report establishes normative values of myocardial lipid content and implicates lipid overstorage in the heart as an important component of impaired glucose tolerance even before the onset of frank diabetes or systolic dysfunction. Assessment of myocardial lipid content could lead to an enhanced understanding of the relationship between abnormalities in glucose handling and myocardial dysfunction, particularly in obese individuals, and potentially provide a new cardiac-specific measure for evaluating responses to interventions that improve global glucose tolerance (eg, weight loss, exercise, and insulin sensitizers).




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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
116/10/1170    most recent
CIRCULATIONAHA.106.645614v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diabetes
*Heart Disease in Women
*Heart Diseases
Related Collections
Right arrow Biochemistry and metabolism
Right arrow Type 2 diabetes
Right arrow Glucose intolerance