Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation. 2007;116:1170-1175
Published online before print August 13, 2007, doi: 10.1161/CIRCULATIONAHA.106.645614
CLINICAL PERSPECTIVE
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
116/10/1170    most recent
CIRCULATIONAHA.106.645614v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diabetes
*Heart Disease in Women
*Heart Diseases
Related Collections
Right arrow Biochemistry and metabolism
Right arrow Type 2 diabetes
Right arrow Glucose intolerance

(Circulation. 2007;116:1170-1175.)
© 2007 American Heart Association, Inc.

Imaging

CLINICAL PERSPECTIVE

The potential impact of this work relates to preclinical detection and prevention of obesity- and diabetes mellitus–related cardiomyopathy. Combined cardiac magnetic resonance imaging and spectroscopy provides a noninvasive diagnostic tool that allows precise measurement of myocardial lipid content. Currently, the technology is available in a handful of centers, but it could become more widely applied, because examination time already is <30 minutes. The present report establishes normative values of myocardial lipid content and implicates lipid overstorage in the heart as an important component of impaired glucose tolerance even before the onset of frank diabetes or systolic dysfunction. Assessment of myocardial lipid content could lead to an enhanced understanding of the relationship between abnormalities in glucose handling and myocardial dysfunction, particularly in obese individuals, and potentially provide a new cardiac-specific measure for evaluating responses to interventions that improve global glucose tolerance (eg, weight loss, exercise, and insulin sensitizers).




This article has been cited by other articles:


Home page
 CirculationHome page
R. W. van der Meer, L. J. Rijzewijk, H. W.A.M. de Jong, H. J. Lamb, M. Lubberink, J. A. Romijn, J. J. Bax, A. de Roos, O. Kamp, W. J. Paulus, et al.
Pioglitazone Improves Cardiac Function and Alters Myocardial Substrate Metabolism Without Affecting Cardiac Triglyceride Accumulation and High-Energy Phosphate Metabolism in Patients With Well-Controlled Type 2 Diabetes Mellitus
Circulation, April 21, 2009; 119(15): 2069 - 2077.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
D. K Mcguire, R. See, S. M Abdullah, P. G Snell, J. M Mcgavock, C. R Ayers, and L. S Szczepaniak
The effect of rosiglitazone on integrated cardiovascular performance, cardiac structure, function and myocardial triglyceride: trial design and rationale
Diabetes and Vascular Disease Research, January 1, 2009; 6(1): 43 - 50.
[Abstract] [PDF]

Home page
 Circ Heart FailHome page
L. R. Loehr, W. D. Rosamond, C. Poole, A. Marie McNeill, P. P. Chang, A. R. Folsom, L. E. Chambless, and G. Heiss
Association of Multiple Anthropometrics of Overweight and Obesity With Incident Heart Failure: The Atherosclerosis Risk in Communities Study
Circ Heart Fail, January 1, 2009; 2(1): 18 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol ImgHome page
L. E. Hudsmith and S. Neubauer
Magnetic resonance spectroscopy in myocardial disease.
J. Am. Coll. Cardiol. Img., January 1, 2009; 2(1): 87 - 96.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. Marfella, M. Barbieri, and G. Paolisso
Insulin Therapy and Lipid Overload in Type 2 Diabetes
JAMA, August 20, 2008; 300(7): 789 - 789.
[Full Text] [PDF]

Home page
 HypertensionHome page
R. Harmancey, C. R. Wilson, and H. Taegtmeyer
Adaptation and Maladaptation of the Heart in Obesity
Hypertension, August 1, 2008; 52(2): 181 - 187.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. J. Chess and W. C. Stanley
Role of diet and fuel overabundance in the development and progression of heart failure
Cardiovasc Res, July 15, 2008; 79(2): 269 - 278.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. W. van der Meer, S. Hammer, H. J. Lamb, M. Frolich, M. Diamant, L. J. Rijzewijk, A. de Roos, J. A. Romijn, and J. W. A. Smit
Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men
J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2702 - 2708.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. W. van der Meer, L. J. Rijzewijk, M. Diamant, S. Hammer, M. Schar, J. J. Bax, J. W.A. Smit, J. A. Romijn, A. de Roos, and H. J. Lamb
The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
Eur. Heart J., June 2, 2008; 29(12): 1516 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. H. Opie
Metabolic Management of Acute Myocardial Infarction Comes to the Fore and Extends Beyond Control of Hyperglycemia
Circulation, April 29, 2008; 117(17): 2172 - 2177.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-a Kim, Y. Wei, and J. R. Sowers
Role of Mitochondrial Dysfunction in Insulin Resistance
Circ. Res., February 29, 2008; 102(4): 401 - 414.
[Abstract] [Full Text] [PDF]

Home page
 DOC NewsHome page
Fat Infiltrates Heart Before Diabetes Onset
DOC News, November 1, 2007; 4(11): 15 - 15.
[Full Text]

Home page
 Circ. Res.Home page
L. S. Szczepaniak, R. G. Victor, L. Orci, and R. H. Unger
Forgotten but Not Gone: The Rediscovery of Fatty Heart, the Most Common Unrecognized Disease in America
Circ. Res., October 12, 2007; 101(8): 759 - 767.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
116/10/1170    most recent
CIRCULATIONAHA.106.645614v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGavock, J. M.
Right arrow Articles by Szczepaniak, L. S.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Diabetes
*Heart Disease in Women
*Heart Diseases
Related Collections
Right arrow Biochemistry and metabolism
Right arrow Type 2 diabetes
Right arrow Glucose intolerance

Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2007 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.