Circulation. 2007;115:2683
doi: 10.1161/CIRCULATIONAHA.107.183529
(Circulation. 2007;115:2683.)
© 2007 American Heart Association, Inc.
Issue Highlights
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LOCAL PRODUCTION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 AND LYSOPHOSPHATIDYLCHOLINE IN THE CORONARY CIRCULATION: ASSOCIATION WITH EARLY CORONARY ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN HUMANS, by Lavi et al.
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Endothelial dysfunction is a hallmark of atherosclerosis and
vascular disease. However, the mechanisms for this dysfunction
remain elusive. In this issue, Lavi and colleagues report on
a human study in which they measured lipoprotein-associated
phospholipase A
2, an enzyme that is involved in cleaving oxidation
products of lipids from both membranes and lipoproteins. They
found that patients with endothelial dysfunction had increased
levels of both the enzyme and the cleaved oxidation product
in the coronary circulation, suggesting that oxidation processes
contribute to endothelial dysfunction in patients with early
atherosclerosis. See p
2715.
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RISK FACTORS FOR THE PROGRESSION OF CORONARY ARTERY CALCIFICATION IN ASYMPTOMATIC SUBJECTS: RESULTS FROM THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), by Kronmal et al.
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Investigators from the Multi-Ethnic Study of Atherosclerosis
(MESA) report the incidence and predictors of coronary artery
calcium (CAC) progression in a community-based, geographically
and racially diverse cohort. As opposed to previous referral-based
studies, their study provides estimates of the rates of progression
that can be expected in unselected routinely studied individuals.
The researchers detected new CAC in 6.6% of individuals per
year, and they noted that men and women had a median annual
CAC progression of 21 and 14 Agatston units per year, respectively.
Not surprisingly, cardiovascular disease risk factors predicted
CAC incidence and progression, indirectly raising the possibility
that aggressive risk factor modification could potentially slow
or arrest the progression of CAC. See p
2722.
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SUSTAINED BENEFIT AT 2 YEARS OF PRIMARY FEMOROPOPLITEAL STENTING COMPARED WITH BALLOON ANGIOPLASTY WITH OPTIONAL STENTING, by Schillinger et al.
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Peripheral arterial disease is an important cause of morbidity.
Frequently, the superficial femoral artery is obstructed and
is the underlying cause of claudication. Although balloon angioplasty
is an established treatment for this condition—as already
introduced by Andreas Grüntzig in the early 1970s—reocclusion
remains a problem. Schillinger et al randomized patients to
either a treatment strategy with primary stent implantation
with self expanding nitinol stents or classic balloon angioplasty.
At 2 years follow-up, they found a sustained benefit of primary
stenting compared with plain balloon angioplasty for treatment
of symptomatic obstructions of the superficial femoral artery.
Restenosis occurred less often after primary stenting and translated
into a tendency for better clinical outcomes. Although results
are preliminary because of sample size, these data favor the
use of nitinol stents for endovascular revascularization of
long superficial femoral artery lesions. Nevertheless, a 45%
restenosis rate in stented patients at 2 years underlines the
need for further improvement of the devices. See p
2745.
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Intracardiac Correlate of the Epsilon Wave in a Patient With
Arrhythmogenic Right Ventricular Dysplasia. See p
e538.
Loculated Pericardial Hematoma Complicating Complex Coronary Interventions: A Rare but Often Missed Diagnosis? See p e540.
Percutaneous Pericardial Access for Mapping and Ablation of Epicardial Ventricular Tachycardias. See p e542.
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Correspondence
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See p
e545.
Related Articles:
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Intracardiac Correlate of the Epsilon Wave in a Patient With Arrhythmogenic Right Ventricular Dysplasia
- David N. Kenigsberg, Gautham Kalahasty, John D. Grizzard, Mark A. Wood, and Kenneth A. Ellenbogen
Circulation 2007 115: e538-e539.
[Extract]
[Full Text]
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Loculated Pericardial Hematoma Complicating Complex Coronary Interventions: A Rare but Often Missed Diagnosis?
- Alessio La Manna, Didier A. Locca, Sanjay K. Prasad, and Carlo Di Mario
Circulation 2007 115: e540-e541.
[Extract]
[Full Text]
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Percutaneous Pericardial Access for Mapping and Ablation of Epicardial Ventricular Tachycardias
- Eduardo Sosa and Mauricio Scanavacca
Circulation 2007 115: e542-e544.
[Extract]
[Full Text]
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Letter by Wiggers et al Regarding Article by Tuunanen et al, "Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure"
- Henrik Wiggers, Mads Halbirk, and Helene Nørrelund
Circulation 2007 115: e545.
[Extract]
[Full Text]
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Local Production of Lipoprotein-Associated Phospholipase A2 and Lysophosphatidylcholine in the Coronary Circulation: Association With Early Coronary Atherosclerosis and Endothelial Dysfunction in Humans
- Shahar Lavi, Joseph P. McConnell, Charanjit S. Rihal, Abhiram Prasad, Verghese Mathew, Lilach O. Lerman, and Amir Lerman
Circulation 2007 115: 2715-2721.
[Abstract]
[Full Text]
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Risk Factors for the Progression of Coronary Artery Calcification in Asymptomatic Subjects: Results From the Multi-Ethnic Study of Atherosclerosis (MESA)
- Richard A. Kronmal, Robyn L. McClelland, Robert Detrano, Steven Shea, João A. Lima, Mary Cushman, Diane E. Bild, and Gregory L. Burke
Circulation 2007 115: 2722-2730.
[Abstract]
[Full Text]
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Sustained Benefit at 2 Years of Primary Femoropopliteal Stenting Compared With Balloon Angioplasty With Optional Stenting
- Martin Schillinger, Schila Sabeti, Petra Dick, Jasmin Amighi, Wolfgang Mlekusch, Oliver Schlager, Christian Loewe, Manfred Cejna, Johannes Lammer, and Erich Minar
Circulation 2007 115: 2745-2749.
[Abstract]
[Full Text]
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LOCAL PRODUCTION OF LIPOPROTEIN...
RISK FACTORS FOR THE...