Circulation. 2006;114:615
(Circulation. 2006;114:615.)
© 2006 American Heart Association, Inc.
Issue Highlights
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ORTHOSTATIC HYPOTENSION PREDICTS MORTALITY IN MIDDLE-AGED ADULTS: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY, by Rose et al.
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Orthostatic hypotension, defined as a decrease of 20 mm Hg of
systolic blood pressure or 10 mm Hg diastolic blood pressure
with standing, occurs in about 5% of people in the community.
This condition predicts adverse effects in older, frail populations,
but its importance in middle-aged groups is less well defined.
Investigators from the Atherosclerosis Risk in Communities (ARIC)
Study compared 674 middle-aged individuals with orthostatic
hypotension and 128 people without the condition. They assessed
whether orthostatic hypotension predicted risk of death over
13 years of follow-up, after adjusting for other important risk
factors. The findings suggest that orthostatic hypotension might
be a new important risk factor with considerable prognostic
importance. See p
630.
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LOCAL CONTROLLED INTRAMYOCARDIAL DELIVERY OF PLATELET-DERIVED GROWTH FACTOR IMPROVES POSTINFARCTION VENTRICULAR FUNCTION WITHOUT PULMONARY TOXICITY, by Hsieh et al.
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Although there is evidence that platelet-derived growth factor
(PDGF) can protect the myocardium from ischemic injury, PDGF
also has the potential to cause pulmonary hypertension. Hsieh
et al tested the ability of self-assembling peptide nanofibers
to deliver PDGF to the myocardium. In rats subjected to myocardial
infarction by coronary artery ligation, injection at the time
of ligation of PDGF via nanofibers reduced infarct size by over
50% and resulted in improved left ventricular size and function
from 1 day to 3 months after infarction. There was no evidence
of pulmonary hypertension or pulmonary artery remodeling. This
experiment suggests that nanofibers can be used to selectively
deliver a therapeutic agent to the myocardium. See p
637.
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PLAQUE VOLUME AND OCCURRENCE AND LOCATION OF PERIPROCEDURAL MYOCARDIAL NECROSIS AFTER PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM DELAYED-ENHANCEMENT MAGNETIC RESONANCE IMAGING, THROMBOLYSIS IN MYOCARDIAL INFARCTION MYOCARDIAL PERFUSION GRADE ANALYSIS AND INTRAVASCULAR ULTRASOUND, by Porto et al.
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In this issue of
Circulation, Porto and colleagues systematically
studied the mechanism of myonecrosis during percutaneous coronary
intervention of native coronary arteries using angiographic
analysis, intravascular ultrasound, and delayed-enhancement
magnetic resonance imaging. Two distinct patterns of myonecrosis
were observed: 1) "adjacent" to the stent and related to side
branch compromise; and 2) "distal" or downstream from the stent
and associated with significantly greater reduction in plaque
volume and closed microvasculature consistent with distal embolization.
The findings of Porto et al have important implications for
efforts to minimize procedural myonecrosis, strongly suggesting
that consideration of side branch anatomy, stent design, and/or
use of distal protection devices during extensive coronary stenting
will be required to optimize clinical outcomes. See p
662.
Visit http://circ.ahajournals.org:
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Cardiology Patient Page
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Carotid Artery Disease. See p
e244.
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Images in Cardiovascular Medicine
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A Rare Form of Midventricular Tako-Tsubo After Emotional Stress
Followed up by Magnetic Resonance Imaging. See p
e248.
Spontaneous Left Atrial Dissection and Hemotoma Mimicking a Cardiac Tumor: Findings From Echocardiography, Cardiac Computed Tomography, Magnetic Resonance Imaging, and Pathology. See p e249.
Wall-Motion Abnormalities Detection With Contrast Enhanced Multislice Computed Tomography. See p e251.
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Book Review
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C-Reactive Protein and Cardiovascular Disease. See p
e253.
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Correspondence
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See p
e255.
Related Articles:
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Carotid Artery Disease
- Piotr Sobieszczyk and Joshua Beckman
Circulation 2006 114: e244-e247.
[Full Text]
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A Rare Form of Midventricular Tako-Tsubo After Emotional Stress Followed up With Magnetic Resonance Imaging
- Henning Steen, Constanze Merten, Hugo A. Katus, and Evangelos Giannitsis
Circulation 2006 114: e248.
[Full Text]
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Spontaneous Left Atrial Dissection and Hematoma Mimicking a Cardiac Tumor: Findings From Echocardiography, Cardiac Computed Tomography, Magnetic Resonance Imaging, and Pathology
- Antonella Lombardo, Nicola Luciani, Vittoria Rizzello, Luigi Natale, Faustino Pennestrí, Riccardo Ricci, Lorenzo Bonomo, Gian Federico Possati, and Filippo Crea
Circulation 2006 114: e249-e250.
[Full Text]
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Wall Motion Abnormalities Detection With Contrast-Enhanced Multislice Computed Tomography
- Teck Wee Wong, Catherine De Larrazabal, H. Khim Boey, and Michael C.L. Lim
Circulation 2006 114: e251-e252.
[Full Text]
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C-Reactive Protein and Cardiovascular Disease
- Joseph V. Messer
Circulation 2006 114: e253-e254.
[Full Text]
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Letter by Bourque et al Regarding Article, "Changing Incidence and Survival for Heart Failure in a Well-Defined Older Population, 1970–1974 and 1990–1994"
- Jamieson M. Bourque, Christopher M. O’Connor, and Eric J. Velazquez
Circulation 2006 114: e255.
[Full Text]
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Plaque Volume and Occurrence and Location of Periprocedural Myocardial Necrosis After Percutaneous Coronary Intervention: Insights From Delayed-Enhancement Magnetic Resonance Imaging, Thrombolysis in Myocardial Infarction Myocardial Perfusion Grade Analysis, and Intravascular Ultrasound
- Italo Porto, Joseph B. Selvanayagam, William J. Van Gaal, Francesco Prati, Adrian Cheng, Keith Channon, Stefan Neubauer, and Adrian P. Banning
Circulation 2006 114: 662-669.
[Abstract]
[Full Text]
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Orthostatic Hypotension Predicts Mortality in Middle-Aged Adults: The Atherosclerosis Risk in Communities (ARIC) Study
- Kathryn M. Rose, Marsha L. Eigenbrodt, Rebecca L. Biga, David J. Couper, Kathleen C. Light, A. Richey Sharrett, and Gerardo Heiss
Circulation 2006 114: 630-636.
[Abstract]
[Full Text]
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Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity
- Patrick C.H. Hsieh, Catherine MacGillivray, Joseph Gannon;, Francisco U. Cruz, and Richard T. Lee
Circulation 2006 114: 637-644.
[Abstract]
[Full Text]
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ORTHOSTATIC HYPOTENSION PREDICTS...
LOCAL CONTROLLED INTRAMYOCARDIAL...