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Circulation. 2006;114:2429

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(Circulation. 2006;114:2429.)
© 2006 American Heart Association, Inc.

Issue Highlights


*    ISCHEMIC HEART DISEASE EVENTS TRIGGERED BY SHORT-TERM EXPOSURE TO FINE PARTICULATE AIR POLLUTION, by Pope et al.
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*ISCHEMIC HEART DISEASE EVENTS...
down arrowEXTENDING THE HORIZON IN...
down arrowPREVENTION OF HIGH-DOSE...
down arrowImages in Cardiovascular...
down arrowCorrespondence
 
Long-term exposure to particulate matter has been linked to chronic lung injury, vascular inflammation, and atherosclerosis in animals and increased risk of pulmonary disease, ischemic heart disease, and death in humans. Short-term exposure to particulate matter has been reported to alter vascular and cardiac function and to trigger myocardial infarction and stroke in humans. The study by Pope et al, reported in this issue of Circulation, took advantage of an almost 13 000 patient catheterization registry and daily community-based monitoring of particulate matter concentrations. The investigators observed that ambient fine particulate pollution was associated with a 45% increased risk of acute coronary syndromes. Furthermore, they report that individuals with catheterization-documented coronary artery disease were particularly vulnerable to pollution. Because exposure to pollution is common in metropolitan settings, these findings may have important implications for public health and public policy debates about acceptable pollution levels. See p 2443.


*    EXTENDING THE HORIZON IN CHRONIC HEART FAILURE: EFFECTS OF MULTIDISCIPLINARY, HOME-BASED INTERVENTION RELATIVE TO USUAL CARE, by Inglis et al.
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up arrowISCHEMIC HEART DISEASE EVENTS...
*EXTENDING THE HORIZON IN...
down arrowPREVENTION OF HIGH-DOSE...
down arrowImages in Cardiovascular...
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Disease management programs are increasing in popularity, but little is known about their long-term impact on patient outcomes. Australian investigators previously conducted a randomized trial of a nurse-led, multidisciplinary, home-based intervention for elderly patients with heart failure and found that the intervention improved survival and reduced hospital admissions. The intervention consisted of no more than 6 months of support. Now Inglis and colleagues have examined the outcomes of these patients 7.5 to 10 years after first entering the study. Their question is whether the relatively brief intervention was able to change the trajectory of the disease in the participants over the following decade. They examined all-cause mortality, event-free survival, hospitalizations, and costs. See p 2466.


*    PREVENTION OF HIGH-DOSE CHEMOTHERAPY–INDUCED CARDIOTOXICITY IN HIGH-RISK PATIENTS BY ANGIOTENSIN-CONVERTING ENZYME INHIBITION, by Cardinale et al.
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up arrowISCHEMIC HEART DISEASE EVENTS...
up arrowEXTENDING THE HORIZON IN...
*PREVENTION OF HIGH-DOSE...
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Cardiac toxicity remains a major limitation for administering anticancer chemotherapy, particularly with the use of higher doses of anthracyclines. An increase in proponent shortly after chemotherapy has been shown to be a strong predictor of the development of left ventricular dysfunction. In this issue of Circulation, Cardinale et al report on their randomized trial of 114 chemotherapy patients with elevated troponins to receive or not receive the angiotensin-converting enzyme inhibitor enalapril. The prespecified echocardiographic end points of the deterioration of left ventricular function were strikingly reduced in the angiotensin-converting enzyme inhibitor–treated patients. See p 2474.

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*    Images in Cardiovascular Medicine
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up arrowISCHEMIC HEART DISEASE EVENTS...
up arrowEXTENDING THE HORIZON IN...
up arrowPREVENTION OF HIGH-DOSE...
*Images in Cardiovascular...
down arrowCorrespondence
 
Reverse Bernheim Phenomenon as a Cause of Exercise-Induced Syncope. See p e618.

Computed Tomography–Guided Biopsy of an Epicardial Mass. See p e621.

Right Ventricular Acupuncture Needle Embolism Detected on Coronary Computed Tomography Angiography. See p e623.


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*    Correspondence
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up arrowISCHEMIC HEART DISEASE EVENTS...
up arrowEXTENDING THE HORIZON IN...
up arrowPREVENTION OF HIGH-DOSE...
up arrowImages in Cardiovascular...
*Correspondence
 
See p e627.


Related Articles:

Reverse Bernheim Phenomenon as a Cause of Exercise-Induced Syncope
Andre d’Avila, Arnaldo Rabischoffsky, and Eduardo Saad
Circulation 2006 114: e618-e620. [Full Text]

Computed Tomography–Guided Biopsy of an Epicardial Mass
Kai Nassenstein and Tobias Schroeder
Circulation 2006 114: e621-e622. [Full Text]

Right Ventricular Acupuncture Needle Embolism Detected on Coronary Computed Tomography Angiography
Young Jin Kim, Ji Youn Kim, Byoung Wook Choi, Ji Eun Nam, Tae Hoon Kim, and Kyu Ok Choe
Circulation 2006 114: e623-e626. [Full Text]

Letter by Bleiziffer et al Regarding Article, "Long-Term Outcomes After Valve Replacement for Low-Gradient Aortic Stenosis: Impact of Prosthesis-Patient Mismatch"
Sabine Bleiziffer, Walter Benno Eichinger, and Ruediger Lange
Circulation 2006 114: e627. [Full Text]

Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition
Daniela Cardinale, Alessandro Colombo, Maria T. Sandri, Giuseppina Lamantia, Nicola Colombo, Maurizio Civelli, Giovanni Martinelli, Fabrizio Veglia, Cesare Fiorentini, and Carlo M. Cipolla
Circulation 2006 114: 2474-2481. [Abstract] [Full Text]

Ischemic Heart Disease Events Triggered by Short-Term Exposure to Fine Particulate Air Pollution
C. Arden Pope, III, Joseph B. Muhlestein, Heidi T. May, Dale G. Renlund, Jeffrey L. Anderson, and Benjamin D. Horne
Circulation 2006 114: 2443-2448. [Abstract] [Full Text]

Extending the Horizon in Chronic Heart Failure: Effects of Multidisciplinary, Home-Based Intervention Relative to Usual Care
Sally C. Inglis, Sue Pearson, Suzette Treen, Tamara Gallasch, John D. Horowitz, and Simon Stewart
Circulation 2006 114: 2466-2473. [Abstract] [Full Text]




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