Circulation. 2006;114:2305
(Circulation. 2006;114:2305.)
© 2006 American Heart Association, Inc.
Issue Highlights
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MYOCARDIAL INJURY AND VENTRICULAR DYSFUNCTION RELATED TO TRAINING LEVELS AMONG NONELITE PARTICIPANTS IN THE BOSTON MARATHON, by Neilan et al.
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The popularity of marathon running continues to grow with nearly
400 000 finishing times recorded in 2005. Although the cardiovascular
event rate during marathon events is low, recent studies suggest
that subclinical myocardial injury may be frequent. In this
issue of
Circulation, Neilan and colleagues further evaluate
this issue by assessing the prevalence of elevated cardiac biomarkers
and their association with echocardiographic and Doppler evidence
of left and right ventricular dysfunction within minutes of
completing a marathon. They also evaluate whether the amount
of training prior to the race affects these parameters. The
results of this provocative study are highlighted and discussed
in an accompanying editorial. See p 2325 (editorial on p
2306).
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DIAGNOSTIC ACCURACY OF NONINVASIVE CORONARY ANGIOGRAPHY IN PATIENTS AFTER BYPASS SURGERY USING 64-SLICE SPIRAL COMPUTED TOMOGRAPHY WITH 330-MS GANTRY ROTATION, by Ropers et al.
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Noninvasive evaluation of bypass grafts has been reported using
multidetector computed tomographic angiography, but studies
of the early-generation scanners have been somewhat limited
based on relatively high numbers on unevaluable segments, especially
at anastomotic sites or in native vessels. In this issue of
Circulation, Ropers et al present a comprehensive report on
64-slice computed tomographic angiography interrogation of patients
with previous bypass surgery, examining performance characteristics
for detecting significant stenoses in grafts, as well as at
anastomotic sites and in distal segments of bypassed native
vessels. They report excellent performance for evaluation of
occlusions or stenoses in grafts and good performance for grafted
and nongrafted native vessels, though limited at times by heavy
calcification. The present report provides clinicians with comprehensive
data on how to apply computed tomographic angiography in patients
with previous bypass surgery and guidance on how to base catheterization
decisions on computed tomographic angiography evaluation. See
p
2334.
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A ONCE-DAILY, ORAL, DIRECT FACTOR XA INHIBITOR, RIVAROXABAN (BAY 59-7939), FOR THROMBOPROPHYLAXIS AFTER TOTAL HIP REPLACEMENT, by Eriksson et al.
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Current oral and intravenous anticoagulants have many limitations
including variable patient response, need for monitoring, and
drug and food interactions. In the current issue of
Circulation,
Eriksson and colleagues compare 5 doses of rivaroxaban, an oral,
direct inhibitor of coagulation Factor Xa to subcutaneous enoxaparin
in patients having elective hip replacement. In the present
study of 618 patients, the investigators report that rivaroxaban
had similar efficacy as enoxaparin for thromboprophylaxis with
increased bleeding at the higher doses. The conclusion is that
the 10mg dose of rivaroxaban will provide comparable rates of
prevention of thromboembolism at a similar rate of bleeding
as enoxaparin. The phase III trial as well as further information
on safety and clinical utility of this oral anticoagulant will
be eagerly anticipated. See p 2374 (editorial p
2313).
Visit http://circ.ahajournals.org:
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Clinician Update
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Clopidogrel Response Variability and Future Therapies: Clopidogrel:
Does One Size Fit All? See p
e600.
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Images in Cardiovascular Medicine
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Giant Atrial Septal Aneurysm in a 25-Year-Old Woman. See p
e607.
Anomalous Origin and Course of the Right Coronary Artery. See p e609.
Intermittent Loss of Second Heart Sound. See p e612.
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Correspondence
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See p
e614.
Related Articles:
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Marathoner’s Heart?
- Paul D. Thompson, Fred S. Apple, and Alan Wu
Circulation 2006 114: 2306-2308.
[Extract]
[Full Text]
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The Scientific Community’s Quest to Identify Optimal Targets for Anticoagulant Pharmacotherapy
- Kenneth W. Mahaffey and Richard C. Becker
Circulation 2006 114: 2313-2316.
[Extract]
[Full Text]
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Clopidogrel Response Variability and Future Therapies: Clopidogrel: Does One Size Fit All?
- Michelle O’Donoghue and Stephen D. Wiviott
Circulation 2006 114: e600-e606.
[Extract]
[Full Text]
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Giant Atrial Septal Aneurysm in a 25-Year-Old Woman
- M. Osranek, F. Bursi, and J.B. Seward
Circulation 2006 114: e607-e608.
[Extract]
[Full Text]
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Anomalous Origin and Course of the Right Coronary Artery
- Emiliano Antonio Maresi, Antonina Maria Argo, Giovanni Paolo Spanò, Giuseppina Maria Novo, Daniela Rosaria Cabibi, and Paolo Giuseppe Procaccianti
Circulation 2006 114: e609-e611.
[Extract]
[Full Text]
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Intermittent Loss of Second Heart Sound
- Jayshree Joshi, Ashutosh D. Wechalekar, Peter J. Bourdillon, Rahul P. Joshi, Amin Rahemtulla, and Philip N. Hawkins
Circulation 2006 114: e612-e613.
[Extract]
[Full Text]
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Letter by Jankowski Regarding Article, "Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress"
- Piotr Jankowski
Circulation 2006 114: e614.
[Extract]
[Full Text]
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Diagnostic Accuracy of Noninvasive Coronary Angiography in Patients After Bypass Surgery Using 64-Slice Spiral Computed Tomography With 330-ms Gantry Rotation
- Dieter Ropers, Falk-Karsten Pohle, Axel Kuettner, Tobias Pflederer, Katharina Anders, Werner G. Daniel, Werner Bautz, Ulrich Baum, and Stephan Achenbach
Circulation 2006 114: 2334-2341.
[Abstract]
[Full Text]
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