Circulation. 2006;114:1343
(Circulation. 2006;114:1343.)
© 2006 American Heart Association, Inc.
Issue Highlights
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LOCALIZATION OF NA+ CHANNEL ISOFORMS AT THE ATRIOVENTRICULAR JUNCTION AND ATRIOVENTRICULAR NODE IN THE RAT, by Yoo et al.
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The anatomical structures, histological architecture, and electrical
correlation of atrioventricular nodal function have been an
area of research for over 100 years. In this issue of
Circulation,
Yoo and colleagues have elegantly demonstrated molecular labeling
of ion channel subtypes in discrete areas of the atrioventricular
conducting system in a rat model. Using immunohistochemistry
techniques, they labeled several sodium channel isoform antibodies
and marker proteins to molecularly illustrate the complex nature
of this critical region. The authors demonstrate areas with
functionally distinct cell types with electrophysiological heterogeneity,
which is important clinically for understanding the development
of variable conduction, dual AV nodal physiology, and reentry.
See p
1360.
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SEX DIFFERENCES IN MAJOR BLEEDING WITH GLYCOPROTEIN IIB/IIIA INHIBITORS: RESULTS FROM THE CRUSADE (CAN RAPID RISK STRATIFICATION OF UNSTABLE ANGINA PATIENTS SUPPRESS ADVERSE OUTCOMES WITH EARLY IMPLEMENTATION OF THE ACC/AHA GUIDELINES) INITIATIVE, by Alexander et al.
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Randomized placebo-controlled clinical trials have demonstrated
the efficacy of glycoprotein IIb/IIIa inhibitors in reducing
the risk of death or myocardial infarction when administered
to patients with non–ST-segment elevation acute coronary
syndrome. Women have a greater predilection for bleeding, the
major risk of this important therapy. In this study by Alexander
et al, the real world experience from 400 hospitals participating
in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina
Patients Suppress Adverse Outcomes With Early Implementation
of the ACC/AHA Guidelines) initiative registry is used to confirm
a 2-fold higher rate of major bleeding in women compared with
men with the use of glycoprotein IIb/IIIa inhibitors. Approximately
a quarter of this excess bleeding can be attributed to excess
dosing of women. Other important caveats about glycoprotein
IIb/IIIa inhibitors use are well delineated in this clinically
important article. See p
1380.
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BLOOD LEAD BELOW 0.48 µmol/L (10 µg/dL) AND MORTALITY AMONG US ADULTS, by Menke et al.
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High blood lead levels (40 µg/dL) have been associated
with increased risk of death in occupational and population-based
samples. The elimination of lead in gasoline and paint products
has resulted in decreasing environmental lead exposure and lower
adult blood lead levels over the past 3 decades. Whether more
modest levels of blood lead are associated with increased mortality,
however, has not been established. Menke and colleagues followed
up almost 140 adult participants in the Third National Health
and Nutrition Examination Survey, recruited from 1988 to 1994,
to examine the relations of blood lead levels to cause-specific
and all-cause mortality. The investigators observed that blood
lead levels in substantively lower levels than previously reported,
above only 2 µg/dL, was associated with excess death from
myocardial infarction, stroke, and all causes, though not from
cancer. The findings have potentially major implications for
public health and the regulation of environmental lead exposures.
See p
1388.
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Giant Compressive Aneurysm of the Left Auricle in a 1-Day-Old
Neonate. See p
e511.
The Case of a Disappearing Left Atrial Appendage Thrombus: Direct Visualization of Left Atrial Thrombus Migration, Captured by Echocardiography, in a Patient With Atrial Fibrillation, Resulting in a Stroke. See p e513.
Directly to the Heart. See p e515.
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Correspondence
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See p
e517.
Related Articles:
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Giant Compressive Aneurysm of the Left Auricle in a 1-Day-Old Neonate
- Thomas Strecker, Andreas Koch, Ralf L. Schild, Helmut Singer, Michael Weyand, and Albrecht Reimann
Circulation 2006 114: e511-e512.
[Extract]
[Full Text]
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The Case of a Disappearing Left Atrial Appendage Thrombus: Direct Visualization of Left Atrial Thrombus Migration, Captured by Echocardiography, in a Patient With Atrial Fibrillation, Resulting in a Stroke
- Amit Parekh, Radhika Jaladi, Sushant Sharma, William A. Van Decker, and Michael D. Ezekowitz
Circulation 2006 114: e513-e514.
[Extract]
[Full Text]
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Directly to the Heart
- Jonathan DeBlois, Sebastien Bergeron, Marie-Helene LeBlanc, Mario Senechal, Jocelyn Gregoire, and Marie Arsenault
Circulation 2006 114: e515-e516.
[Extract]
[Full Text]
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Letter by Thalhammer et al Regarding Article, "External Carotid Artery–Internal Jugular Vein Fistula: A Complication of Internal Jugular Cannulation"
- Christoph Thalhammer, Markus Aschwanden, and Kurt A. Jaeger
Circulation 2006 114: e517.
[Extract]
[Full Text]
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Localization of Na+ Channel Isoforms at the Atrioventricular Junction and Atrioventricular Node in the Rat
- Shin Yoo, Halina Dobrzynski, Vadim V. Fedorov, Shang-Zhong Xu, Tomoko T. Yamanushi, Sandra A. Jones, Mitsuru Yamamoto, Vladmir P. Nikolski, Igor R. Efimov, and Mark R. Boyett
Circulation 2006 114: 1360-1371.
[Abstract]
[Full Text]
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Sex Differences in Major Bleeding With Glycoprotein IIb/IIIa Inhibitors: Results From the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) Initiative
- Karen P. Alexander, Anita Y. Chen, L. Kristin Newby, Janice B. Schwartz, Rita F. Redberg, Judith S. Hochman, Matthew T. Roe, W. Brian Gibler, E. Magnus Ohman, Eric D. Peterson for the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Investigators
Circulation 2006 114: 1380-1387.
[Abstract]
[Full Text]
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Blood Lead Below 0.48 µmol/L (10 µg/dL) and Mortality Among US Adults
- Andy Menke, Paul Muntner, Vecihi Batuman, Ellen K. Silbergeld, and Eliseo Guallar
Circulation 2006 114: 1388-1394.
[Abstract]
[Full Text]
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